ABSTRACT
Clinical and microbiological study of wound discharge from 35 patients demonstrated a relationship between biological properties of S. aureus, the causative agent of burn infection, and the course of the infected burn trauma. The prognostic importance of the antioxidant properties of these staphylococci was established: in cases of the unfavorable course of the burn process they showed essentially greater resistance to peroxinitrite and higher superoxide dismutase activity in comparison with the cultures isolated from patients with uncomplicated wound infection.
Subject(s)
Burns/microbiology , Peroxynitrous Acid/pharmacology , Staphylococcal Infections/microbiology , Staphylococcus aureus/pathogenicity , Wound Infection/microbiology , Adult , Drug Resistance, Bacterial , Humans , Male , Middle Aged , Prognosis , Staphylococcal Infections/diagnosis , Staphylococcus aureus/drug effects , Staphylococcus aureus/isolation & purification , Superoxide Dismutase/metabolism , Wound Infection/diagnosisABSTRACT
The dynamics of the level of catalase and superoxidedismutase (SOD) expression by S. aureus isolated in persistent experimental kidney infection is described. A rise in the activity of the staphylococci under study during transition of the infectious process from the alteration to persistence stage. Changes in the expression of SOD and catalase were observed simultaneously with a decrease in hemolytic, fibrinolytic and protease activity, as well as in the presence of more pronounced clumping and an increase in the production of protein A, the antilysozyme and anticomplement activity of staphylococcal clones obtained from kidney tissue. The significance of all above-mentioned phenomena in the persistence of microorganisms is discussed.
