ABSTRACT
Extremely favorable results are obtained with the use of microcrystals of methylprednisolone acetate for treatment of bone cysts. These results have led to a complete suspension of surgical treatment of bone cysts since 1974. On the basis of these results with corticosteroids, a surgical procedure that involves an incision at the fracture location and bone graft inserted is not indicated. Results following surgery indicate a recurrence rate of approximately 25% to 30%. Since we are as yet unable to explain the mechanism by which the local injection of MPA promotes bone replacement of the cyst, the present observations only reaffirm the hypothesis (presented in our early publications) that the corticosteroid exerts a destructive action on the pathological tissue of the lesion, thus favoring a progressive process of repair. We consider this explanation valid even for lesions, e.g., eosinophilic granulomas and nonossifying fibromas, in which this method of treatment has had varying degrees of success.
Subject(s)
Bone Cysts/drug therapy , Methylprednisolone/analogs & derivatives , Adolescent , Bone Cysts/diagnostic imaging , Bone Neoplasms/drug therapy , Child , Child, Preschool , Chondroblastoma/drug therapy , Eosinophilic Granuloma/drug therapy , Female , Fibroma/drug therapy , Humans , Infant , Long-Term Care , Male , Methylprednisolone/therapeutic use , Methylprednisolone Acetate , Radiography , RecurrenceABSTRACT
The treatment of bone cysts by topical injection of methylprednisolone acetate was initiated at the end of 1973, and the late results are reported in this paper. In seventy-two cases followed up for one to three years favourable results have been obtained in about 90 per cent. The technique of local injection and the surgical equipment employed, in the case of focal recurrences, are considered. With this method, surgical treatment of bone cysts in youth is seldom necessary.
Subject(s)
Bone Cysts/drug therapy , Methylprednisolone/therapeutic use , Administration, Topical , Adolescent , Adult , Bone Cysts/diagnostic imaging , Bone Cysts/pathology , Bone Development/drug effects , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Infant , Injections , Male , Methylprednisolone/administration & dosage , RadiographySubject(s)
Bone Cysts/drug therapy , Bone Diseases/drug therapy , Methylprednisolone/administration & dosage , Administration, Topical , Bone Neoplasms/drug therapy , Bone Neoplasms/secondary , Eosinophilic Granuloma/drug therapy , Female , Follow-Up Studies , Humans , Male , Methylprednisolone/therapeutic useABSTRACT
This is a report of a method for treatment of spondylolisthesis based upon: (1) preoperative reduction of the olisthesis by plaster casts; (2) fixation of the reduction by posterior arthrodesis, accompanied by a system of instrumentation which has been developed by the authors. The treatment of severe spondyloptosis in six children and of spondylolisthesis in 14 adults is considered separately, because of the somewhat different problems in the two different age groups.
