ABSTRACT
Our experience led us to test the hypothesis that lymph nodes are not uncommon within the substance of the human female breast mound. The following specimen types and sources were used to survey the presence of intramammary lymph nodes in the human female breast mound: (1) cadaver breasts; (2) community hospital breast specimens; and (3) university and VA hospital specimens. We found true lymph nodes within and associated with breast specific tissue (ie, tissue that includes duct and gland structures), thereby validating the hypothesis posed. We discuss the significance of these findings in terms of our dominant patient care paradigm (the Triple Test-physical examination, imaging, and fine-needle aspiration [FNA]) and the choice of patient care management options. We conclude the following: lymph nodes occur in any quadrant of the breast mound; recognizing the possibility of intramammary lymph nodes is important when choosing between patient management options; intramammary lymph nodes can be sampled by FNA; intramammary lymph nodes can contain various disease processes; and in the Oregon Health Sciences University Multidisciplinary Breast Clinic, these intramammary lymph nodes are commonly identified by imaging methods and are more likely to be sampled by FNA than either by core or excisional biopsy.
Subject(s)
Breast Diseases/diagnosis , Breast/anatomy & histology , Breast/pathology , Lymph Nodes/anatomy & histology , Lymph Nodes/pathology , Adult , Aged , Aged, 80 and over , Biopsy, Needle , Cadaver , Female , Hospitals, Community , Hospitals, University , Hospitals, Veterans , Humans , Lymph Nodes/diagnostic imaging , Mammography , Middle Aged , Ultrasonography, MammaryABSTRACT
PURPOSE: To test, in an animal model, two potentially suitable materials for nonsurgical selective tubal sterilization. MATERIALS AND METHODS: A hydrogel that forms an in situ plug by phase inversion of a polymer solution was placed in four rabbit fallopian tubes, and a proprietary collagen glue was placed into three rabbit fallopian tubes by means of transvaginal fluoroscopic fallopian tube catheterization. As controls, 11 tubes were catheterized without sterilization material injection. The rabbits were bred, and the presence of embryos was confirmed with palpation and at autopsy. Histologic analysis was performed. RESULTS: The short-term contraception rate was 100% in the hydrogel group, 33% in the collagen glue group, and 0% in the control group (P < .001 hydrogel group, P not significant in collagen group). Inflammation was minimal in the three groups (P not significant). CONCLUSION: The collagen glue had an insufficient contraceptive effect and should be abandoned. The hydrogel used proved effective and biocompatible, and long-term studies of this compound are warranted.
PIP: The purpose of this study was to test, in an animal model, two potentially suitable materials for nonsurgical selective tubal sterilization. A hydrogel that forms an in situ plug by phase inversion of a polymer solution was placed in four rabbit fallopian tubes, and a proprietary collagen glue was placed into three rabbit fallopian tubes by means of transvaginal fluoroscopic fallopian tube catheterization. As controls, 11 tubes were catheterized without sterilization material injection. The rabbits were bred, and the presence of embryos was confirmed with palpation and at autopsy. Histologic analysis was performed. The short-term contraception rate was 100% in the hydrogel group, 33% in the collagen glue group, and 0% in the control group (P .001 hydrogel group, P not significant in collagen group). Inflammation was minimal in the three groups (P not significant). The collagen glue had an insufficient contraceptive effect and should be abandoned. The hydrogel used proved effective and biocompatible, and long-term studies of this compound are warranted.
Subject(s)
Acrylonitrile/therapeutic use , Catheterization/methods , Collagen/therapeutic use , Dimethyl Sulfoxide/therapeutic use , Sterilization, Tubal/methods , Tissue Adhesives/therapeutic use , Acrylonitrile/administration & dosage , Acrylonitrile/adverse effects , Acrylonitrile/chemistry , Animals , Autopsy , Biocompatible Materials/chemistry , Breeding , Collagen/administration & dosage , Collagen/adverse effects , Contraception , Dimethyl Sulfoxide/administration & dosage , Dimethyl Sulfoxide/adverse effects , Dimethyl Sulfoxide/chemistry , Disease Models, Animal , Embryo, Mammalian , Fallopian Tubes/anatomy & histology , Fallopian Tubes/drug effects , Female , Fluoroscopy , Palpation , Rabbits , Radiography, Interventional , Salpingitis/chemically induced , Tissue Adhesives/adverse effectsABSTRACT
We prospectively identified 12 patients who had a shelf at the margin of the placenta consistent with the diagnosis of circumvallate placenta. Ten patients were followed to delivery and three placentas were sent for pathologic analysis. Circumvallate placenta was diagnosed by gross inspection in all three but was confirmed by microscopic analysis in only two. One of these patients had placental abruption and cesarean delivery for fetal distress at 27 weeks. Circumvallate placenta is another cause of uterine band, sheet, or shelf. The finding can be associated with a normal obstetric outcome but may predispose to placental complications.
Subject(s)
Placenta/diagnostic imaging , Ultrasonography, Prenatal , Abruptio Placentae/etiology , Cesarean Section , Delivery, Obstetric , Female , Fetal Distress/etiology , Follow-Up Studies , Hematoma/etiology , Humans , Placenta/pathology , Placenta Diseases/etiology , Pregnancy , Pregnancy Outcome , Pregnancy Trimester, Second , Prospective StudiesABSTRACT
PURPOSE: To test a method of nonsurgical sterilization. MATERIALS AND METHODS: A hydrogel that forms an in situ plug by phase inversion of a polymer solution was placed into fallopian tubes of eight rabbits by means of transvaginal rabbits by means of transvaginal fluoroscopic fallopian tube catheterization. The rabbits were bred, and the presence of embryos was confirmed with palpation and at autopsy. RESULTS: Seven of the eight rabbits became pregnant. Six of these rabbits contained embryos in the control uterus but not in the uterus on the side of the hydrogel injection. The seventh rabbit had embryos in both uteri, but the hydrogel had been expelled. All seven tubes that contained hydrogel showed evidence of acute and chronic salpingitis and a foreign-body reaction. The tube from which hydrogel had been expelled and the eight control tubes were not inflamed. CONCLUSION: Transcervical catheter methods of tubal occlusion and sterilization are promising, but a non-reactive material is needed.
Subject(s)
Acrylonitrile , Dimethyl Sulfoxide , Gels , Sodium Tetradecyl Sulfate , Sterilization, Tubal/methods , Animals , Catheterization/methods , Female , Foreign-Body Reaction/chemically induced , Rabbits , Salpingitis/chemically inducedABSTRACT
RATIONALE AND OBJECTIVES: A potential method of nonsurgical tubal sterilization was tested in rabbits. METHODS: Metal coils were designed which could be placed into the uterotubal junction using transvaginal fluoroscopic fallopian tube catheterization. These metal coils were successfully placed unilaterally in the uterotubal junction of 32 rabbits. The contralateral fallopian tube and uterus were used as a control. The rabbits were bred, and the presence of pregnancies was confirmed by palpation. RESULTS: In 21 rabbits (66%), the coil stayed in place. Sixteen rabbits had multiple gestations on the side without the coil and no gestations on the side with the coil. Three rabbits had gestations on both sides, even though the coil was in place, and two rabbits never conceived. In 11 rabbits (34%) the coil was dislodged as early as 5 days and as late as 18 weeks after the procedure. Five of these 11 rabbits had bilateral embryos, 4 had embryos only on the side contralateral to where the coil had been, and 2 never conceived. CONCLUSIONS: The metal coil does prevent conception if it stays in place at the uterotubal junction. However, the coil failed to prevent pregnancy in 3 of 19 rabbits, and was dislodged in 11 rabbits, giving an overall failure rate for contraception of 44%.
Subject(s)
Contraceptive Devices, Female , Sterilization, Tubal/methods , Animals , Equipment Design , Female , Rabbits , Stainless SteelSubject(s)
Enema/adverse effects , Hysterosalpingography/adverse effects , Adult , Animals , Barium Sulfate/pharmacology , Fallopian Tubes/drug effects , Fallopian Tubes/pathology , Female , Humans , Peritoneal Diseases/chemically induced , Peritonitis/etiology , Rabbits , Tissue Adhesions/chemically induced , Uterine Diseases/chemically inducedABSTRACT
The inflammatory effects of fallopian tube catheterization and selective injection of seven contrast agents (ethiodized oil, diatrizoate meglumine 52%, diatrizoate meglumine 66%, iothalamate meglumine 60%, iopamidol, ioxitol, and ioxaglate) were evaluated in 88 rabbits. The contrast agent used was randomly selected and selectively injected after unilateral catheterization; the contralateral side was used for control. Pathologic inspection of right and left uteri with attached fallopian tubes and ovaries was done without knowledge of side of catheterization or duration of time since catheterization. The degree and location of inflammation were noted. Inflammation disappeared by 4 days in five of seven contrast agents. Iothalamate meglumine 60% and iopamidol required 2 weeks for disappearance of inflammation. Essentially no inflammation was associated at any time with ioxaglate. These findings suggest that all of these contrast agents would be clinically acceptable for direct injection into the human fallopian tube.
Subject(s)
Contrast Media/adverse effects , Fallopian Tubes/drug effects , Hysterosalpingography , Animals , Contrast Media/administration & dosage , Diatrizoate Meglumine/administration & dosage , Diatrizoate Meglumine/adverse effects , Ethiodized Oil/administration & dosage , Ethiodized Oil/adverse effects , Fallopian Tubes/pathology , Female , Injections , Iohexol/administration & dosage , Iohexol/adverse effects , Iohexol/analogs & derivatives , Iopamidol/administration & dosage , Iopamidol/adverse effects , Iothalamate Meglumine/administration & dosage , Iothalamate Meglumine/adverse effects , Ioxaglic Acid/administration & dosage , Ioxaglic Acid/adverse effects , Rabbits , Salpingitis/chemically induced , Salpingitis/pathologyABSTRACT
A rabbit model for testing the safety and effectiveness of diagnostic and interventional techniques of fallopian tube catheterization is presented. Hysterography with injection into the terminal portion of the uterine horn visualized the fallopian tube in only 6% of cases; however, this increased from 33% to 50% by pretreatment with progesterone, administration of glucagon or phentolamine, or increased pressure of injection with balloon obstruction of the uterine horn. Salpingography with a catheter introduced in the tubal ostium or directly inside the tube was most effective and resulted in a consistent (100%) visualization of the fallopian tube. The technique also allowed coaxial introduction of small diameter guidewires and catheters deep into the fallopian tube.