Subject(s)
Echinococcosis, Hepatic/diagnosis , Echocardiography , Heart Diseases/diagnosis , Hematoma/diagnosis , Pericardium , Humans , Male , Middle AgedABSTRACT
Electrophysiologic modifications produced by intravenous administration of 0.1 mg/Kg Oxprenolol were studied in 16 subjects with estimated normal impulse formation and conduction. Significant effects were sinus bradycardia, mild increase of sino-atrial conduction time, depression of intranodal conduction and prolongation of A-V node refractory periods. Sinus node recovery time and atrial refractory periods were unchanged. Infranodal conduction and the refractory periods of the His-Purkinje system, as well as of the bundle branches, were unchanged. These effects are compared with those observed after intravenous Propranolol and Prindolol.
Subject(s)
Heart Conduction System/drug effects , Oxprenolol/pharmacology , Adult , Aged , Arrhythmias, Cardiac/drug therapy , Atrioventricular Node/drug effects , Female , Humans , Male , Middle Aged , Oxprenolol/therapeutic use , Sinoatrial Node/drug effectsABSTRACT
The acute electrophysiologic effects of intravenous Bunaphtine 1,5 mg/kg body weight, a new antiarrhythmic drug, were studied in 19 subjects with estimated normal impulse formation and conduction. Significant effects were sinus bradycardia, prolongation of atrial refractory periods, depression of intranodal and infranodal conduction and prolongation of His-Purkinje system refractory periods. These properties are compared with those of amiodarone and quinidine and form the basis for a correct use of Bunaphtine in the management of arrhythmias.
