ABSTRACT
Ten children who had severe dietary chloride deficiency during early infancy have grown normally during their first 4 to 5 years. With the exception of one child who did not get into the sitting position alone until he was 9 1/2 months of age, the patients reached the usual developmental milestones of the first 2 years during the expected age intervals. Developmental and psychological testing indicates that all of the children have at least average ability. However, three children have shown behavior patterns that may interfere with successful school performance. Serum creatinine and urea nitrogen concentrations appear to be normal as does renal concentrating capacity. During a 4-year follow-up, one child has shown persistent and a second intermittent microscopic hematuria.
Subject(s)
Chlorides , Deficiency Diseases/etiology , Infant Food/adverse effects , Alkalosis/etiology , Alkalosis/metabolism , Alkalosis/physiopathology , Child Development , Deficiency Diseases/metabolism , Deficiency Diseases/physiopathology , Failure to Thrive/etiology , Failure to Thrive/metabolism , Failure to Thrive/physiopathology , Growth , Hematuria/urine , Humans , Hypokalemia/etiology , Hypokalemia/metabolism , Hypokalemia/physiopathology , Infant , Kidney/physiopathology , SyndromeABSTRACT
A double-blind trial failed to demonstrate any significant short-term effects of clomipramine in doses recommended for use in general practice (in addition to the usual range of psychotherapeutic help) in the treatment of children with school refusal and neurotic disorder. Patterns of improvement were also studied for the sample as a whole irrespective of treatment. Neither age nor sex were significantly related to improvement, except on one behavioural measure where girls initially did better than boys. In addition, it was found that there was a rapid relief of depression but neurotic symptomatology tended to persist.
