1.
Adv Exp Med Biol
; 132: 363-72, 1980.
Article
in English
| MEDLINE
| ID: mdl-7424717
ABSTRACT
Inhibition by ethanol of microsomal hydroxylation in vitro was studied for a series of barbiturates. Considerable variation was found both in the type and the degree of inhibition exerted by ethanol in this series. Degree of inhibition by ethanol, however, correlated well with both the increases in sleeping-time and the prolongation of half-life time of barbiturates found in rats acutely pretreated with a subnarcotic dose of ethanol. Results are interpreted to favour a distinct pharmacokinetic concept of barbiturate-ethanol interaction to occur in rats.
Subject(s)
Barbiturates/metabolism , Ethanol/pharmacology , Microsomes, Liver/metabolism , Animals , Drug Interactions , Hydroxylation , In Vitro Techniques , Kinetics , Male , Rats , Sleep/drug effects , Time Factors
2.
Bibl Psychiatr
; (151): 76-81, 1975.
Article
in German
| MEDLINE
| ID: mdl-1156351
Subject(s)
Antipyrine/urine , Carbamazepine/therapeutic use , Epilepsy/drug therapy , Liver/enzymology , Phenytoin/therapeutic use , Adult , Bilirubin/blood , Carbamazepine/administration & dosage , Creatinine/urine , Epilepsy/metabolism , Female , Half-Life , Humans , Hydroxylation , Male , Middle Aged , Phenytoin/administration & dosage , Phenytoin/blood , Time Factors , Trigeminal Neuralgia/drug therapy , Trigeminal Neuralgia/metabolism
3.
Naunyn Schmiedebergs Arch Pharmacol
; 287 Suppl: R90, 1975.
Article
in English
| MEDLINE
| ID: mdl-238154
4.
Eur J Clin Pharmacol
; 7(4): 281-5, 1974 Jul 26.
Article
in English
| MEDLINE
| ID: mdl-4851632
Subject(s)
Liver/metabolism , Pharmaceutical Preparations/metabolism , Phenytoin/pharmacology , Adult , Antipyrine , Bilirubin/blood , Colorimetry , Creatinine/metabolism , Epilepsy/drug therapy , Half-Life , Humans , Hydroxylation , Jaundice/drug therapy , Male , Middle Aged , Phenelzine/metabolism , Phenytoin/blood , Phenytoin/therapeutic use
5.
Arzneimittelforschung
; 24(7): 1023-5, 1974 Jul.
Article
in German
| MEDLINE
| ID: mdl-4211429
Subject(s)
Antipyrine/metabolism , Epilepsy/drug therapy , Phenytoin/pharmacology , Administration, Oral , Antipyrine/blood , Antipyrine/urine , Biodegradation, Environmental , Creatinine/urine , Epilepsy, Tonic-Clonic/drug therapy , Epilepsy, Tonic-Clonic/enzymology , Half-Life , Humans , Hydroxylation , Liver/drug effects , Liver/enzymology , Liver/metabolism , Male , Microsomes, Liver/enzymology , Microsomes, Liver/metabolism , Phenytoin/blood , Phenytoin/therapeutic use , Stimulation, Chemical
6.
Naunyn Schmiedebergs Arch Pharmacol
; 282(Suppl): suppl 282:R87, 1974.
Article
in English
| MEDLINE
| ID: mdl-4276643
