A woman with a dangling digit.

Ainhum (dactylolysis spontanea) is a distinct clinical and radiological disorder of dark-skinned people characterized by a progressive development of a constricting band encircling the toe which usually results in spontaneous amputation. Ainhum mainly occurs in African natives, but in times of global migration and tourism, Ainhum is likely to be more often encountered outside Africa. Even though the clinical presentation can mimic more common entities such as arthritis and trauma, the correct diagnosis and treatment is easy if one knows this unusual entity.

The effect of anti-L-selectin (aselizumab) in multiple traumatized patients--results of a phase II clinical trial.

OBJECTIVE: The objectives of this study were to evaluate safety (primary) and clinical efficacy (secondary) of the humanized monoclonal anti-L-selectin antibody aselizumab in severely injured patients. DESIGN: Prospective phase II, parallel group, double-blind, randomized, placebo-controlled clinical trial. SETTING: Fourteen medical intensive care units or trauma units in level I trauma centers in Belgium, Germany, and Poland. PATIENTS: Eighty-four patients with a sustained trauma due to a blunt or penetrating injury and a total Injury Severity Scale score of > or =25. INTERVENTIONS: Patients received either aselizumab at dosages of 0.5, 1, or 2 mg/kg or placebo within 6 hrs of the traumatic event and were followed for 6 wks. MEASUREMENTS AND MAIN RESULTS: The number of expeditable adverse events increased dose dependently over the aselizumab groups compared with placebo. There were no statistically significant differences between all groups regarding leukopenia and risk of infection. No immunologic response following infusion of aselizumab was noted. The number of patients with multiple organ failure, defined as a median value of the total Goris Multiple Organ Failure score of > or =5 on > or =2 consecutive days within 14 days, was not significantly different for the 0.5 mg/kg, 1 mg/kg, 2 mg/kg, and placebo groups. There were no statistically significant differences in time of mechanical ventilation, length of stay in an intensive care unit, and total duration of hospitalization between treatment groups. CONCLUSIONS: Aselizumab was associated with a higher rate of infections and leucopenia; however, this difference was not significantly different compared with placebo. For all efficacy variables, aselizumab presented no significant trends but only a few scattered statistically significant differences between groups.

Medical telematics in disaster response.

INTRODUCTION: Every year many disasters cause thousands of injuries, deaths, refugees. Depending on the kind of disaster (train/plane accident, flood, earthquake) not only an acute emergency medicine treatment but also general and family medicine and hospital treatment have to be safeguarded over a longer time-period in the disaster area. PROBLEM: Regarding to a lot of organizations, institutions and disaster teams taking part in the disaster assistance is there any lack of work or data flow in the medical treatment? METHODS: From the ODRA flood 1997, the high speed train crash in ESCHEDE 1998, the DANUBE flood 1999 and the ELBE flood in 2002 experience reports were collected. They were analysed with emphasis on data and work flow in the medical treatment and its command system: Standardised command structure? Communication problems? Used communication lines? Language problems? Medical Intelligence distribution? Use of Patient Tracking System? Triage problems? RESULTS: The use of spoken radio communication causes transmission mistakes or misunderstandings and radio-overload and need connection-set-up-time for each call. Manual distribution of same data for many receivers using different communication lines causes a time shift in the up-to-date-information. Language problems during the ODRA flood between German and Polish people led to longer reaction times. Up-to-date triage results as well as up-to-date transportation and hospital information are necessary for medical evacuation. Compared with other reports about these disasters the quality of disaster management depends on the quality of communication and information. CONCLUSION: The use of health telematics in disaster response helps to cope with the scenario. Modern technologies provide support for building up medical aid although the normal infrastructure is destroyed. To cope with disaster scenarios there are some telematic tools which can be used:--Computer-based Command and Control System--Telemedical support --Data-ressources-network /Medical Intelligence. A further study is recommended to evaluate the real impact of using these telematic tools in a disaster.

NOAH--a mobile emergency care system.

The German emergency care system is a very sophisticated one. However, negative headlines like "Emergency Patient Tourism" appearing from time to time, have provoked a thorough deficit analysis which revealed two weak points: communication and documentation. The communication system presently used is a rather outdated one employing analogue voice radio between the ambulance cars/helicopters and the dispatch center and telephone communication between the dispatch center and the emergency rooms. To document the emergency case the on-scene physician is required to fill out a form. A survey showed that many of these forms are filled out incompletely and/or inconsistently or are even missing completely. NOAH, which means "Emergency Organization and Administration Aid" ("Notfall Organisations- und Arbeits-Hilfe" in German) intends to address both of these communication and documentation deficits. The on-scene physician is equipped with a mobile ruggedised PC with an internal digital radio-modern. It provides a direct, digital communication channel from the on-scene physician to the emergency physician starting from the first minutes of the treatment of the emergency patient. It also provides an easy-to-fill-out variant of the paper form mentioned above with an on-line help function and visual aids. A typical course of events with the communication part of NOAH is as follows. The on-scene physician is alarmed via NOAH and can obtain details of the emergency during the approach. He can enter the status codes ("on the move","arrived at the emergency scene","arrived at the patient", etc.) with NOAH. During the first minutes of the treatment of the patient the physician enters a so called "First Message", which requires only 10 to 15 seconds. This message contains basic information like sex, age and the injuries of the patient. It helps the dispatch center (if the on-scene physician desires so) to make an informed recommendation where to bring the patient. This message is also forwarded to the emergency room of the destination hospital, where it can help to start appropriate preparations for the patient. When the on-scene physician has enough time, he can already bring up the documentation masks and give further information to the emergency room.