Seismic observations, numerical modeling, and geomorphic analysis of a glacier lake outburst flood in the Himalayas.

Glacial lake outburst floods (GLOFs) are a substantial hazard for downstream communities in vulnerable regions, yet unpredictable triggers and remote source locations make GLOF dynamics difficult to measure and quantify. Here, we revisit a destructive GLOF that occurred in Bhutan in 1994 and apply cross-correlation-based seismic analyses to track the evolution of the GLOF remotely (~100 kilometers from the source region). We use the seismic observations along with eyewitness reports and a downstream gauge station to constrain a numerical flood model and then assess geomorphic change and current state of the unstable lakes via satellite imagery. Coherent seismic energy is evident from 1 to 5 hertz beginning approximately 5 hours before the flood impacted Punakha village, which originated at the source lake and advanced down the valley during the GLOF duration. Our analysis highlights potential benefits of using real-time seismic monitoring to improve early warning systems.

Acceleration of ice loss across the Himalayas over the past 40 years.

Himalayan glaciers supply meltwater to densely populated catchments in South Asia, and regional observations of glacier change over multiple decades are needed to understand climate drivers and assess resulting impacts on glacier-fed rivers. Here, we quantify changes in ice thickness during the intervals 1975-2000 and 2000-2016 across the Himalayas, using a set of digital elevation models derived from cold war-era spy satellite film and modern stereo satellite imagery. We observe consistent ice loss along the entire 2000-km transect for both intervals and find a doubling of the average loss rate during 2000-2016 [-0.43 ± 0.14 m w.e. year-1 (meters of water equivalent per year)] compared to 1975-2000 (-0.22 ± 0.13 m w.e. year-1). The similar magnitude and acceleration of ice loss across the Himalayas suggests a regionally coherent climate forcing, consistent with atmospheric warming and associated energy fluxes as the dominant drivers of glacier change.

Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study.

Substance use often starts in adolescence and poses a major problem for society and individual health. The dopamine system plays a role in substance use, and catechol-O-methyltransferase (COMT) is an important enzyme that degrades dopamine. The Val(108/158) Met polymorphism modulates COMT activity and thus dopamine levels, and has been linked to substance use. COMT gene methylation, on the other hand, may affect expression and thus indirectly COMT activity. We investigated whether methylation of the COMT gene was associated with adolescents' substance use. Furthermore, we explored whether the COMT Val(108/158) Met polymorphism interacts with COMT gene methylation in association with substance use. In 463 adolescents (mean age=16, 50.8% girls), substance use (cigarette smoking, alcohol and cannabis use) was assessed with self-report questionnaires. From blood samples, COMT Val(108/158) Met genotype and methylation rates of membrane bound (MB) and soluble (S) COMT promoters were assessed. MB-COMT promoter methylation was associated with non-daily smoking [odds ratio (OR)=1.82, P=0.03], but not with daily smoking (OR=1.20, P=0.34), MB-COMT promoter methylation was not associated with alcohol use. Adolescents with the Met/Met genotype and high rates of MB-COMT promoter methylation were less likely to be high-frequent cannabis users than adolescents with the Val/Val or Val/Met genotype. S-COMT promoter methylation was not associated with substance use. These results indicate that there is an association between substance use and COMT gene methylation. Although this association is complex, combining genetic and epigenetic variation of the COMT gene may be helpful in further elucidating the influence of the dopamine system on substance use in adolescence.

Rapid thinning of Pine Island Glacier in the early Holocene.

Pine Island Glacier, a major outlet of the West Antarctic Ice Sheet, has been undergoing rapid thinning and retreat for the past two decades. We demonstrate, using glacial-geological and geochronological data, that Pine Island Glacier (PIG) also experienced rapid thinning during the early Holocene, around 8000 years ago. Cosmogenic (10)Be concentrations in glacially transported rocks show that this thinning was sustained for decades to centuries at an average rate of more than 100 centimeters per year, which is comparable with contemporary thinning rates. The most likely mechanism was a reduction in ice shelf buttressing. Our findings reveal that PIG has experienced rapid thinning at least once in the past and that, once set in motion, rapid ice sheet changes in this region can persist for centuries.

Effectiveness of reducing the risk of eating-related problems using the German school-based intervention program, "Torera", for preadolescent boys and girls.

Representative surveys indicate that eating disorders are an increasing problem, especially among (pre)adolescents. We assessed the effects of a German school-based primary prevention program ("Torera") for seventh graders. Torera especially relates to pathological eating behavior in the realm of bulimia nervosa or binge eating disorder. The program is built upon two previously evaluated modules for sixth graders with a gender-specific adaption. The coeducational intervention involves nine manual-guided lessons touching a wide range of eating-related problems. Twenty-two Thuringian secondary schools (n = 256 boys and 277 girls, aged 11-13 years at baseline) participated in a trial with 2 control groups (untreated and pretreated) with pre-post assessment. Primary outcomes were conspicuous eating behavior and body self-esteem, measured by standardized questionnaires (SCOFF, EAT-26D, and FBeK). Girls and students at risk showed significant improvement with small (d = 0.35) to medium (d = 0.66) effect sizes on eating behavior, significantly mediated by body self-esteem. Boys only improved with respect to eating attitudes, revealing a small effect size (d = 0.35). With relatively low implementation costs (about 2.50 per student), Torera provides an efficient model for reducing risky eating behavior and strengthening body self-esteem without negative side effects. To improve the effectiveness of the intervention, further research efforts focusing on at-risk groups (secondary prevention) and structural actions for prevention (e.g., offering healthy school catering) are needed.

The last glacial termination.

A major puzzle of paleoclimatology is why, after a long interval of cooling climate, each late Quaternary ice age ended with a relatively short warming leg called a termination. We here offer a comprehensive hypothesis of how Earth emerged from the last global ice age. A prerequisite was the growth of very large Northern Hemisphere ice sheets, whose subsequent collapse created stadial conditions that disrupted global patterns of ocean and atmospheric circulation. The Southern Hemisphere westerlies shifted poleward during each northern stadial, producing pulses of ocean upwelling and warming that together accounted for much of the termination in the Southern Ocean and Antarctica. Rising atmospheric CO2 during southern upwelling pulses augmented warming during the last termination in both polar hemispheres.

Legalized gambling and its impacts in a central Minnesota vacation community: A case study.

The economic and social effects of legalized gambling in a Minnesota community were studied (1) to inform the state's citizens and decision-makers of the community impacts of legalized gambling, particularly the cumulative community revenue loss, (2) to gather comparative data in a geographically and economically distinct area to determine the extent to which regional gambling rates and revenue losses vary, and (3) to refine existing research methods. The community and the types of gambling available are described. Data on gambling expenditures were obtained from various state agencies. Lottery and casino winners were interviewed to discover how their winnings were distributed. Annual (1991) player losses, profit margins, taxes, and resulting economic and social impacts are discussed. The most consequential findings are estimates of annual player losses ($3.3 million; $205 per capita) and community revenue losses ($2.2 million; $138 per capita). Per capita lottery and charitable gambling player losses were 9.4% lower than those of a community studied earlier; per capita community revenue losses were 7.6% lower. Research methods developed in this study provided more reliable estimates than those used previously. Suggestions are offered to increase reliability for future studies.

"Minnesota slots": An observational study of pull tab gambling.

A study of pull tab gambling in Minnesota was undertaken to describe the state's most popular form of gambling. The study also focused on the detection of any abuses or addictive problems that might be associated with it. Pull tab gambling is similar to slot machine gambling. The game, fundamentals of play, and some of the behaviors of pull tab gamblers are described. Various playing patterns and strategies, pull tab etiquette, the numbers and types of players, amounts of money bet, player's wins and losses, house profits, gambling abuses, behaviors which may indicate problem gambling, and dealer/player relationships are discussed. The study concludes with suggestions to help minimize some of the actual and potential problems and abuses that accompany pull tab gambling.

The influence of time, gender and group size on heavy drinking in public bars.

Four hypotheses are tested focusing on the small group basis of legal intoxication. A sample of 1,996 isolates and groups gathering to drink at a 12% random sample of 565 bars in a two-county metropolitan area was observed using a stratified random time sampling schedule. Multiple regression was used to test the hypotheses. The hypothesis that group size affects proportion of group drinking heavily during one visit to a bar was not supported. Average group alcohol consumption, group gender composition and average duration of group stay in bar do affect proportion of group drinking heavily.

On the potential health effects of consuming "non-alcoholic" or "de-alcoholized" beverages.

This paper reviews the potential health risks for persons who consume the newly available "non-alcoholic" or "de-alcoholized" beverages which may contain trace amounts of ethanol (less than 0.5% by volume). The discussion includes relative risk rates for chemical dependency, fetal alcohol syndrome, chemical and natural hypersensitivity, cancer, cardiomyopathy, hypertension and cirrhosis for those who drink standard alcoholic drinks and "non-alcoholic" drinks. It is concluded that non-alcoholic drinks pose little risk for developing alcohol related problems based on our current physiological and psychocultural knowledge.

Alcohol metabolism and sensitivity reactions among the Reddis of South India.

Alcohol was given orally to 41 healthy young male volunteers from small Hindu (Reddis) farming villages in south and central Andhra Pradesh, India. A complete description of the Reddis study, plus transcultural group differences, is given, and the alcohol metabolism and sensitivity literature is critically reviewed.

Hepatic lipid droplets. Isolation, morphology and composition.

The floating lipid layer isolated centrifugation of rat liver was examined for composition and ultrastructure. It was chiefly composed of triglycerides and cholesterol esters plus much smaller amounts of free cholesterol, diglycerides, phospholipid and protein. No free fatty acids were detected. The triglyceride and cholesterol ester fractions consisted mostly of esters of linoleic acid, oleic acid and palmitic acid. Electron micrographs of the floating lipid layer revealed numerous spherical osmiophilic droplets having a mean diameter of 0.5-2mum with a very-thin dense outer coat. Similar structures were observed as organelles in electron micrographs of the intact liver cell. The amount of triglyceride in the layer decreased in rats starved for 72h, but pellet triglyceride (homogenate minus the floating lipid layer) was unchanged. These results suggest that the floating lipid layer is the representative in vitro of lipid-rich organelles which probably function as a depot form of hepatic-cell neutral lipid.