New onset of type 2 diabetes as a complication after cancer diagnosis: A systematic review.

BACKGROUND: Despite improved survival rates, cancer survivors are experiencing worse health outcomes with complications of treatment, such as type 2 diabetes mellitus (T2D), that may deteriorate survivorship. The purpose of this review was to provide a comprehensive review of T2D incidence following cancer diagnosis. METHODS: The study included: (1) cohort studies, (2) cancer diagnosis by a doctor, (3) incidence of T2D after diagnosis of cancer, and (4) adult patients over 18 years. Studies that focused on patients who had T2D as a preexisting condition at cancer diagnosis were excluded. RESULTS: Of a total of 16 studies, overall incidence of T2D ranged from 5.4% to 55.3%. The highest T2D incidence rate was observed in colorectal patients with cancer (53%). While results in prostate patients with cancer were mixed, patients who underwent androgen deprivation therapy (ADT) had a significantly higher incidence of new-onset T2D (12.8%, p = 0.01). Patients treated with chemotherapy within 1-5 years of initial diagnosis of colorectal cancer were at approximately 30% higher risk of T2D. One study found that 48% of T2D was preventable with optimal management during the process of patient care. CONCLUSION: Blood glucose management may allow physicians to intervene early and improve outcomes among patients with cancer.

An Economic Evaluation of Home Versus Laboratory-Based Diagnosis of Obstructive Sleep Apnea.

STUDY OBJECTIVES: We conducted an economic analysis of the HomePAP study, a multicenter randomized clinical trial that compared home-based versus laboratory-based testing for the diagnosis and management of obstructive sleep apnea (OSA). DESIGN: A cost-minimization analysis from the payer and provider perspectives was performed, given that 3-mo clinical outcomes were equivalent. SETTING: Seven academic sleep centers. PARTICIPANTS: There were 373 subjects at high risk for moderate to severe OSA. INTERVENTIONS: Subjects were randomized to either home-based limited channel portable monitoring followed by unattended autotitration with continuous positive airway pressure (CPAP), versus a traditional pathway of in-laboratory sleep study and CPAP titration. MEASUREMENTS AND RESULTS: From the payer perspective, per subject costs for the laboratory-based pathway were $1,840 (95% confidence interval [CI] $1,660, $2,015) compared to $1,575 (95% CI $1,439, $1,716) for the home-based pathway under the base case. Costs were $264 (95% CI $39, $496, P = 0.02) in favor of the home arm. From the provider perspective, per subject costs for the laboratory arm were $1,697 (95% CI $1,566, $1,826) compared to $1,736 (95% CI $1,621, $1,857) in the home arm, for a difference of $40 (95% CI -$213, $142, P = 0.66) in favor of the laboratory arm under the base case. The provider operating margin was $142 (95% CI $85, $202,P < 0.01) in the laboratory arm, compared to a loss of -$161 (95% CI -$202, -$120, P < 0.01) in the home arm. CONCLUSIONS: For payers, a home-based diagnostic pathway for obstructive sleep apnea with robust patient support incurs fewer costs than a laboratory-based pathway. For providers, costs are comparable if not higher, resulting in a negative operating margin. CLINICALTRIALSGOV IDENTIFIER: NCT00642486.

Teen pregnancy and sexually transmitted infections in youth: a community prevention evidence-based program in Texas, USA / Infecciones de transmisión en la juventud: un programa de prevención comunitario basado en la evidencia, en Texas EEUU

Teen pregnancies and sexually transmitted diseases (STDs) continue to be a major health, social and financial problem across the country, and especially in Texas. While national research has shown that abstinence education is not working, the Texas Legislature, Texas School System and the Lubbock community still require “Abstinence-Only” education. The current paper is based on a community prevention evidence-based program in Lubbock, Texas entitled “Teen Straight Talk” (TST, 2007). TST is designed to educate and provide information on the topics of body image, teen and peer pressure, depression and suicide, along with understanding sexuality and how the body works, abstinence, contraception, teenage pregnancy, STDs, protection and sexual responsibility. The program reduces barriers between adults and parents and the youth they care for. TST is a joint effort among faculty, undergraduate and graduate students from Texas Tech University and Texas Tech University Health Sciences Center and community partners. Empirical data has been collected since 2008 to fulfill the program main goals: a) Understand parent’s knowledge and attitudes on sexual development as well as increase awareness of needs and benefits of comprehensive sexual education programs for parents and adolescents; b) Train volunteer students to promote healthy teenage sexual development in the Lubbock Community, c) Deliver comprehensive, medically, psychologically and sociologically correct sexual education to families and teenagers concerning risk and protective factors related to sexual activity. Empirical and social implications of TST are discussed.

El embarazo juvenil y las infecciones de transmisión sexual (ITS) continúan siendo un problema de salud, económico y social de índole mayor en Estados Unidos particularmente en Texas. Mientras evidencia empírica a nivel nacional demuestra que la educación basada en abstinencia no funciona, la legislatura en Texas, el sistema educativo en las escuelas y en las comunidades de Texas aun requieren que se utilicen los programas de “Solo-Abstinencia.” Este artículo esta basado en un programa comunitario de prevención basado en evidencia empírica en Lubbock, Texas llamado “Teen Straight Talk” (TST, 2007). TST fue diseñado para educar y proveer información sobre los temas de imagen corporal, presión de pares y adolescentes, depresión y suicidio, en conjunto con el desarrollo sexual y el entendimiento acerca de cómo funciona nuestro cuerpo, abstinencia, métodos anticonceptivos, embarazo juvenil, enfermedades de transmisión sexual, protección y responsabilidad sexual. El programa intenta reducir las barreras entre adultos y padres de familia y sus hijos adolescentes, y se ha implementado en ingles y español. TST es un esfuerzo conjunto entre investigadores, estudiantes de pregrado y postgrado en Texas Tech University y Texas Tech University Ciencias de la Salud y líderes comunitarios. Desde el 2008, datos empíricos han sido recolectados para evaluar las metas del proyecto: a) Entender el conocimiento y las actitudes de los padres acerca del desarrollo sexual y a la vez informar acerca de la necesidad y los beneficios de los programas comprensivos de educación sexual para padres y adolescentes, b) Entrenar estudiantes voluntarios para promover la salud y el desarrollo sexual de los adolescentes en la comunidad de Lubbock

Postoperative complications in patients with obstructive sleep apnea.

BACKGROUND: Unrecognized obstructive sleep apnea (OSA) is associated with unfavorable perio-perative outcomes among patients undergoing noncardiac surgery (NCS). METHODS: The study population was chosen from 39,771 patients who underwent internal medicine preoperative assessment between January 2002 and December 2006. Patients undergoing NCS within 3 years of polysomnography (PSG) were considered for the study, whereas those < 18 years of age, with a history of upper airway surgery, or who had had minor surgery under local or regional anesthesia were excluded. Patients with an apnea-hypopnea index (AHI) ≥ 5 were defined as OSA and those with an AHI < 5 as control subjects. For adjusting baseline differences in age, sex, race, BMI, type of anesthesia, American Society of Anesthesiology class, and medical comorbidities, the patients were classified into five quintiles according to a propensity score. RESULTS: Out of a total of 1,759 patients who underwent both PSG and NCS, 471 met the study criteria. Of these, 282 patients had OSA, and the remaining 189 served as control subjects. The presence of OSA was associated with a higher incidence of postoperative hypoxemia (OR, 7.9; P = .009), overall complications (OR, 6.9; P = .003), and ICU transfer (OR, 4.43; P = .069), and a longer hospital length of stay (LOS), (OR, 1.65; P = .049). Neither an AHI nor use of continuous positive airway pressure at home before surgery was associated with postoperative complications (P = .3 and P = .75, respectively) or LOS (P = .97 and P = .21, respectively). CONCLUSIONS: Patients with OSA are at higher risk of postoperative hypoxemia, ICU transfers, and longer hospital stay.