Temporary Protective Shoulder Implants for Revision Surgery with Bone Glenoid Grafting.

This article describes the development of a temporary protective glenoid prosthesis placed between the augmentation and humeral head prosthesis during the healing phase of shoulder prosthesis revision with necessary reconstruction of the bony structure of the glenoid. The glenoid protection prosthesis ensures the fixation of the augmentation material and protects the screws from contact with the metallic humeral head prosthesis. Another approach of the development is a reduction of the resorption of the augmentation by targeted mechanical stimulation of the tissue. The aim should be to achieve significantly improved conditions for the implantation of a new glenoid component at the end of the healing phase of the augmentation material in comparison to the current standard method. The development of the protective prosthesis was carried out according to specific needs and includes the collection of requirements and boundary conditions, the design and technical detailing of the implant, the verification of the development results as well as the validation of the design. For the verification, FEM simulations (Finite Element Analysis) were performed to estimate the mechanical stability in advance. Mechanical tests to confirm the stability and abrasion behavior have been carried out and confirm the suitability of the protective implant. The result of the present work is the detailed technical design of two variants of a glenoid protective prosthesis "GlenoProtect" for use in revision procedures on shoulder joints-with large-volume defects on the glenoid-treated by arthroplasty and the necessity of augmenting the glenoid, including a description of the surgical procedure for implantation.

[Pain as adverse drug reaction]. / Die unerwünschte Arzneimittelwirkung Schmerz.

We present a multidisciplinary (anaesthesiology--clinical pharmacy--bioinformatics) analysis of pain as possible adverse drug reaction taking different manifestations of pain, indication groups, relevance to the Austrian drug market and possible mechanistic influence of drugs on development and apprehension of pain into consideration.We designed an overview that shows how transmitters that play a part in nociception and antinociception can be influenced by drugs. This allows conclusions to the dolorigene potential of therapeutics.