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1.
Dermatoendocrinol ; 4(3): 298-307, 2012 Jul 01.
Article in English | MEDLINE | ID: mdl-23467449

ABSTRACT

Skin has been reported to reflect the general inner-health status and aging. Nutrition and its reflection on skin has always been an interesting topic for scientists and physicians throughout the centuries worldwide. Vitamins, carotenoids, tocopherols, flavonoids and a variety of plant extracts have been reported to possess potent anti-oxidant properties and have been widely used in the skin care industry either as topically applied agents or oral supplements in an attempt to prolong youthful skin appearance. This review will provide an overview of the current literature "linking" nutrition with skin aging.

2.
Exp Dermatol ; 18(10): 821-32, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19555434

ABSTRACT

Interest in sebaceous gland physiology and its diseases is rapidly increasing. We provide a summarized update of the current knowledge of the pathobiology of acne vulgaris and new treatment concepts that have emerged in the last 3 years (2005-2008). We have tried to answer questions arising from the exploration of sebaceous gland biology, hormonal factors, hyperkeratinization, role of bacteria, sebum, nutrition, cytokines and toll-like receptors (TLRs). Sebaceous glands play an important role as active participants in the innate immunity of the skin. They produce neuropeptides, excrete antimicrobial peptides and exhibit characteristics of stem cells. Androgens affect sebocytes and infundibular keratinocytes in a complex manner influencing cellular differentiation, proliferation, lipogenesis and comedogenesis. Retention hyperkeratosis in closed comedones and inflammatory papules is attributable to a disorder of terminal keratinocyte differentiation. Propionibacterium acnes, by acting on TLR-2, may stimulate the secretion of cytokines, such as interleukin (IL)-6 and IL-8 by follicular keratinocytes and IL-8 and -12 in macrophages, giving rise to inflammation. Certain P. acnes species may induce an immunological reaction by stimulating the production of sebocyte and keratinocyte antimicrobial peptides, which play an important role in the innate immunity of the follicle. Qualitative changes of sebum lipids induce alteration of keratinocyte differentiation and induce IL-1 secretion, contributing to the development of follicular hyperkeratosis. High glycemic load food and milk may induce increased tissue levels of 5alpha-dihydrotestosterone. These new aspects of acne pathogenesis lead to the considerations of possible customized therapeutic regimens. Current research is expected to lead to innovative treatments in the near future.


Subject(s)
Acne Vulgaris/etiology , Acne Vulgaris/therapy , Acne Vulgaris/metabolism , Animals , Humans , Sebaceous Glands/microbiology , Sebaceous Glands/pathology , Sebaceous Glands/physiology
3.
Arch Dermatol Res ; 300(8): 397-413, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18690467

ABSTRACT

Acne is the most common skin disease which affects millions of people worldwide. Seborrhea and sebostasis are major cosmetic problems but also lead occasionally to diseases. This article summarizes the data of newest research of sebostasis, seborrhoea and acne made possible through the development of human and animal sebocyte culture models.


Subject(s)
Acne Vulgaris/physiopathology , Dermatitis, Seborrheic/physiopathology , Sebaceous Glands/cytology , Sebaceous Glands/physiopathology , Sebum/physiology , Cells, Cultured , Corticotropin-Releasing Hormone/physiology , Fatty Acids/biosynthesis , Female , Humans , Inflammation/etiology , Lipogenesis , Male , Peroxisome Proliferator-Activated Receptors/physiology , Receptors, Cell Surface/physiology , Sebaceous Glands/drug effects
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