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1.
Pediatr Dev Pathol ; 24(3): 175-186, 2021.
Article in English | MEDLINE | ID: mdl-33475042

ABSTRACT

INTRODUCTION: Although fetal brain injury due to COL4A1 gene mutation is well documented, fetal central nervous system (CNS) and placental histopathology lack description. We report CNS and placental pathology in fetal cases with symptomatic COL4A1 mutation. METHODS: We retrieved four autopsy cases of COL4A1 related disease, confirmed by genetic sequencing after fetal brain injury was detected. RESULTS: One case was a midgestation fetus with residua of ventricular zone hemorrhage and normal placental villi. Three cases were 30-32 week gestation fetuses: two demonstrated CNS small vessel thrombosis, with CNS injury. Both demonstrated high grade placental fetal vascular malperfusion (FVM). One additionally showed villous dysmorphism, the other demonstrated mild villous immaturity. The fetus whose placenta demonstrated high grade FVM was growth restricted. A fourth fetus demonstrated schizencephaly with a CNS arteriopathy with smooth muscle cell degeneration and cerebral infarcts; the placenta demonstrated severe villous dysmorphism and low grade FVM. DISCUSSION: These cases confirm that small vessel disease is important in producing intracranial pathology in COL4A1mutation. We report an arteriopathy distinct from microvascular thrombosis and demonstrate that placental pathology is common in fetal COL4A1 related disease. This tentatively suggests that placental pathology may contribute to CNS abnormalities by affecting circulatory sufficiency.


Subject(s)
Brain/abnormalities , Collagen Type IV/genetics , Fetus/abnormalities , Placenta Diseases/genetics , Placenta/pathology , Female , Humans , Mutation , Placenta Diseases/pathology , Pregnancy
2.
Ultrasound Obstet Gynecol ; 40(5): 604-6, 2012 Nov.
Article in English | MEDLINE | ID: mdl-22344957

ABSTRACT

We report the prenatal magnetic resonance imaging (MRI) appearance of polymicrogyria with pathologic correlation in a fetus with congenital parvovirus B19 infection. Prenatal ultrasound revealed non-immune hydrops, but detected no fetal brain abnormalities. A subsequent fetal MRI scan performed at 23 weeks' gestation demonstrated bilateral polymicrogyria, which was confirmed at autopsy. To our knowledge, prenatal diagnosis of polymicrogyria in association with congenital parvovirus B19 infection has not been previously described. This case provides further evidence for brain abnormalities resulting from congenital parvovirus B19 infection, and suggests that fetal neuroimaging with MRI would be of value in suspected cases of congenital parvovirus infection.


Subject(s)
Erythema Infectiosum/diagnosis , Hydrops Fetalis/diagnosis , Magnetic Resonance Imaging , Malformations of Cortical Development/diagnosis , Pregnancy Complications, Infectious/diagnosis , Ultrasonography, Prenatal , Abortion, Induced , Adult , Diagnosis, Differential , Erythema Infectiosum/diagnostic imaging , Erythema Infectiosum/virology , Female , Humans , Hydrops Fetalis/diagnostic imaging , Hydrops Fetalis/virology , Malformations of Cortical Development/diagnostic imaging , Malformations of Cortical Development/virology , Parvovirus B19, Human , Pregnancy , Pregnancy Complications, Infectious/diagnostic imaging , Pregnancy Complications, Infectious/virology
3.
Am J Physiol Gastrointest Liver Physiol ; 279(4): G683-91, 2000 Oct.
Article in English | MEDLINE | ID: mdl-11005754

ABSTRACT

We previously suggested that the profound, sustained vasoconstriction noted in 3-day-old swine intestine after a moderate episode of ischemia-reperfusion (I/R) reflects the unmasking of underlying constrictor tone consequent to a loss of endothelium-derived nitric oxide (NO). In this study, we sought to determine whether endothelin-1 (ET-1) was the unmasked constrictor and whether selective loss of endothelial ET(B) receptors, which mediate NO-based vasodilation, participated in the hemodynamic consequences of I/R in newborn intestine. Studies were performed in innervated, autoperfused intestinal loops in 3- and 35-day-old swine. Selective blockade of ET(A) receptors with BQ-610 had no effect on hemodynamics under control conditions; however, when administered before and during I/R, BQ-610 significantly attenuated the post-I/R vasoconstriction and reduction in arteriovenous O(2) difference in the younger group. In 3-day-old intestine, reduction of intestinal O(2) uptake to a level similar to that noted after I/R by lowering tissue temperature had no effect on the response to BQ-610 or ET-1, indicating that the change in response to BQ-610 noted after I/R was not simply consequent to the reduction in tissue O(2) demand. In studies in mesenteric artery rings suspended in myographs, we observed a leftward shift in the dose-response curve for ET-1 after selective blockade of ET(B) receptors with BQ-788 in 3- but not 35-day-old swine. Rings exposed to I/R in vivo behaved in a manner similar to control rings treated with BQ-788 or endothelium-denuded non-I/R rings.


Subject(s)
Endothelin-1/pharmacology , Hemodynamics/physiology , Intestine, Small/blood supply , Ischemia/physiopathology , Mesenteric Arteries/physiology , Oligopeptides/pharmacology , Vasoconstriction/physiology , Animals , Animals, Newborn , Endothelin Receptor Antagonists , Female , Hemodynamics/drug effects , In Vitro Techniques , Intestine, Small/physiology , Intestine, Small/physiopathology , Male , Mesenteric Arteries/drug effects , Muscle Contraction/drug effects , Muscle Contraction/physiology , Muscle, Smooth, Vascular/drug effects , Muscle, Smooth, Vascular/physiology , Oxygen/blood , Oxygen Consumption/drug effects , Perfusion , Piperidines/pharmacology , Receptor, Endothelin A , Swine , Vasoconstriction/drug effects , Vasoconstrictor Agents/pharmacology , Vasodilation/drug effects , Vasodilation/physiology , Viper Venoms/pharmacology , omega-N-Methylarginine/pharmacology
4.
Am J Med Genet ; 87(1): 45-8, 1999 Nov 05.
Article in English | MEDLINE | ID: mdl-10528246

ABSTRACT

We report on a male fetus with partial trisomy 2p21-2pter and monosomy 15q26-15qter due to t(2,15)(p21;q26). This fetus had a typical trisomy 2p phenotype including minor facial anomalies, musculoskeletal defects and two unusual findings: polydactyly and anencephaly. The observation of anencephaly adds support to the theory that genetic material mapping to chromosome band 2p24 is involved in neural tube development. In addition, we propose that a gene on 2p23 may play a role in the morphogenetic patterning of hands and feet.


Subject(s)
Chromosomes, Human, Pair 2/genetics , Trisomy , Abortion, Eugenic , Adolescent , Anencephaly/genetics , Anencephaly/pathology , Fatal Outcome , Female , Fetal Death , Fetus/abnormalities , Gestational Age , Humans , In Situ Hybridization, Fluorescence , Karyotyping , Male , Polydactyly/genetics , Polydactyly/pathology , Pregnancy , Syndrome
5.
Ann Thorac Surg ; 67(4): 1151-2, 1999 Apr.
Article in English | MEDLINE | ID: mdl-10320267

ABSTRACT

We describe an aortic valve-sparing operation in a small child with an ascending aortic aneurysm and root dilatation. The operation avoids the need for a prosthetic valve and long-term anticoagulation. Thus, the procedure is an attractive alternative for young children in whom a Ross procedure is not feasible.


Subject(s)
Aortic Aneurysm/surgery , Aortic Valve , Aorta/surgery , Blood Vessel Prosthesis Implantation/methods , Child, Preschool , Female , Humans , Methods
6.
Circulation ; 96(10): 3549-54, 1997 Nov 18.
Article in English | MEDLINE | ID: mdl-9396454

ABSTRACT

BACKGROUND: Inflammatory diseases of the heart, including myocarditis and cardiac transplant rejection, are important causes of morbidity and mortality in children. Although viral infection may be suspected in either of these clinical conditions, the definitive etiology is often difficult to ascertain. Furthermore, the histology is identical for both disorders. Coxsackievirus has long been considered the most common cause of viral myocarditis; however, we previously demonstrated by polymerase chain reaction (PCR) analysis that many different, and sometimes unexpected, viruses may be responsible for myocarditis and cardiac rejection. In this study, we describe the association of parvovirus genome identified through PCR analysis of cardiac tissue in the clinical setting of myocarditis and cardiac allograft rejection. METHODS AND RESULTS: Myocardial tissue from endomyocardial biopsy, explant, or autopsy was analyzed for parvovirus B19 using primers designed to amplify a 699-base pair PCR product from the VP1 gene region. Samples tested included those obtained from patients with suspected myocarditis (n=360) or transplant rejection (n=200) or control subjects (n=250). Parvoviral genome was identified through PCR in 9 patients (3 myocarditis; 6 transplant) and no control patients. Of the 3 patients with myocarditis, 1 presented with cardiac arrest leading to death, 1 developed dilated cardiomyopathy, and the other gradually improved. Four of the 6 transplant patients had evidence of significant rejection on the basis of endomyocardial biopsy histology. All transplant patients survived the infection. CONCLUSIONS: Parvovirus is associated with myocarditis in a small percentage of children and may be a potential contributor to cardiac transplant rejection. PCR may provide a rapid and sensitive method of diagnosis.


Subject(s)
Graft Rejection/virology , Heart Transplantation , Myocarditis/virology , Parvoviridae Infections , Parvovirus B19, Human/genetics , Adolescent , Adult , Child , Child, Preschool , Genome, Viral , Graft Rejection/pathology , Humans , Infant , Infant, Newborn , Myocarditis/pathology , Parvoviridae Infections/diagnosis , Polymerase Chain Reaction , Prognosis
7.
Pediatr Pathol Lab Med ; 17(6): 951-8, 1997.
Article in English | MEDLINE | ID: mdl-9353835

ABSTRACT

This report describes the clinical and histologic features of a pulmonary tumor in a 14-year-old girl that is most consistent with a rare entity described in the literature as "pulmonary endodermal tumor resembling fetal lung" (PET). This tumor is composed of glycogen-rich columnar cells forming complex glands with focal festooning and mitotic activity, admixed with solid "morules" of cells with eosinophilic cytoplasm and focal nuclear clearing. Patchy tumor necrosis and a bland stroma were also present. Immunoreactivity for carcinoembryonic antigen (CEA), alpha 1-antichymotrypsin, and 12E7 was present in glandular cells and for human chorionic gondatropin (HCG), alpha 1-antichymotrypsin, and 12E7 in morular cells. Ultrastructural features are those of an epithelial tumor. Related entities have been called "pulmonary blastoma lacking sarcomatous elements" and "adenocarcinoma of fetal lung type." Most cases of PET have occurred in adults, and the histologic features thought to have prognostic significance in small published series are applied to our case, in which the patient remains well and without evidence of tumor recurrence or metastasis for 28 months following local resection as the sole treatment.


Subject(s)
Carcinoma/pathology , Lung Neoplasms/pathology , Pulmonary Blastoma/pathology , Adolescent , Diagnosis, Differential , Female , Humans , Immunohistochemistry , Karyotyping , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/surgery , Lung Neoplasms/ultrastructure , Radiography
8.
Ann Thorac Surg ; 61(1): 229-31, 1996 Jan.
Article in English | MEDLINE | ID: mdl-8561568

ABSTRACT

An extremely rare coronary artery anomaly where the left main coronary artery arose anteriorly from the right coronary sinus and coursed in front of the right ventricular outflow tract was present in a patient with tetralogy of Fallot. Preoperative angiocardiography was interpreted as normal. Operative recognition was prevented by dense adhesions and a partial intramural course. Division of the vessel at repair resulted in death of the patient. The angiographic pattern associated with this anomaly is very unusual, and in many views looks deceptively normal. Details are presented.


Subject(s)
Coronary Vessel Anomalies/complications , Tetralogy of Fallot/complications , Coronary Angiography , Coronary Vessel Anomalies/diagnostic imaging , Coronary Vessel Anomalies/surgery , Female , Humans , Infant , Tetralogy of Fallot/diagnostic imaging , Tetralogy of Fallot/surgery
9.
J Pediatr Surg ; 30(9): 1370-2, 1995 Sep.
Article in English | MEDLINE | ID: mdl-8523250

ABSTRACT

Congenital diaphragmatic hernia (CDH) continues to be one of the most challenging problems in pediatric surgery. The overall mortality rate remains at 40%, and death is caused by pulmonary hypoplasia and persistent pulmonary hypertension. It has been suggested that in utero repair of the defect should be performed to allow the lungs to grow and develop, in the hope of preventing fatal pulmonary insufficiency. The authors report the survival of a 960-g premature infant with CDH, suggesting that ex utero repair is possible in a very low birth weight infant.


Subject(s)
Hernias, Diaphragmatic, Congenital , Infant, Low Birth Weight , Infant, Premature, Diseases , Female , Humans , Infant, Newborn , Infant, Premature , Survivors
11.
J Surg Oncol ; 51(1): 68-70, 1992 Sep.
Article in English | MEDLINE | ID: mdl-1325578

ABSTRACT

A case of mullerian adenosarcoma of the uterus with sarcomatous overgrowth is described. The patient was also found to have bilateral polycystic ovaries. This 25 year-old white female presented with irregular vaginal bleeding and was diagnosed as having mullerian adenosarcoma with sarcomatous overgrowth by dilatation, curettage, and biopsy. Total abdominal hysterectomy, bilateral salpingo-oophorectomy with lymph node sampling were performed.


Subject(s)
Polycystic Ovary Syndrome/pathology , Sarcoma/pathology , Uterine Neoplasms/pathology , Wilms Tumor/pathology , Adult , Combined Modality Therapy , Female , Humans , Hysterectomy , Polycystic Ovary Syndrome/complications , Polycystic Ovary Syndrome/surgery , Uterine Neoplasms/complications , Uterine Neoplasms/surgery , Wilms Tumor/complications , Wilms Tumor/surgery
12.
Am J Med Genet ; 37(4): 583-91, 1990 Dec.
Article in English | MEDLINE | ID: mdl-2175543

ABSTRACT

Sonography permitted the diagnosis of Fraser syndrome (cryptophthalmos-syndactyly syndrome) at 18.5 weeks of gestation in a fetus whose parents had had a previous affected child. The karyotype of that child was 46,XX,inv(9)(p11q21); the karyotype of the phenotypically normal father and of the fetus was 46,XY,inv(9)(p11q21). Findings on sonography included oligohydramnios with nonvisualization of kidneys, hypertelorism and microphthalmia, and markedly enlarged lungs. On autopsy at 19 weeks, findings included renal agenesis, cryptophthalmos with multiple abnormalities of the eyes and ocular adnexa, laryngeal atresia, pulmonary hyperplasia with accelerated maturation, absence of the Eustachian tube with connective tissue occupying the tympanic cavity and bone occluding the external acoustic meatus, and soft-tissue webbing between the digits. This is the second reported instance of prenatal diagnosis of Fraser syndrome in the second trimester. The histopathologic findings in Fraser syndrome at this gestational age, in particular the eye and ear, have not been described previously.


Subject(s)
Abnormalities, Multiple/pathology , Syndactyly/pathology , Abnormalities, Multiple/genetics , Chromosome Inversion , Chromosomes, Human, Pair 9 , Ear/abnormalities , Ear/pathology , Eye Abnormalities/pathology , Eyelids/abnormalities , Eyelids/pathology , Female , Humans , Kidney/abnormalities , Kidney/pathology , Larynx/abnormalities , Larynx/pathology , Lung/abnormalities , Male , Pregnancy , Syndactyly/genetics , Syndrome
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