ABSTRACT
The physical findings, clinical signs, age, breed and sex distributions, and laboratory data of 117 dogs with untreated Cushing's syndrome were reviewed. Poodles, Dachshunds, and Boxers of all ages were found to be at increased risk, as were dogs of all breeds greater than or equal to 6 years old. Polydipsia, polyuria, progressive bilaterally symmetric alopecia, and abdominal distention were the most frequently observed clinical signs and physical findings. Lymphopenia, eosinopenia, above normal values of serum alkaline phosphatase, serum cholesterol, and sulfobromphthalein dye retention, and below normal urine specific gravity were the most frequent abnormalities found in the laboratory data. About 50% of the dogs had urinary tract infections. Final diagnosis was established on the basis of abnormally high plasma corticosteroid values in response to an intramuscular injection of adrenocorticotropic hormone.
Subject(s)
Blood Glucose/metabolism , Cushing Syndrome/veterinary , Dog Diseases/diagnosis , 17-Ketosteroids/urine , Adrenal Cortex Hormones/blood , Animals , Cushing Syndrome/diagnosis , Cushing Syndrome/metabolism , Dog Diseases/metabolism , Dogs , Female , Insulin/blood , MaleSubject(s)
Cushing Syndrome/veterinary , Dichlorodiphenyldichloroethane/therapeutic use , Dog Diseases/drug therapy , 17-Hydroxycorticosteroids/urine , Administration, Oral , Adrenal Glands/pathology , Animals , Corticosterone/blood , Cushing Syndrome/blood , Cushing Syndrome/diagnosis , Cushing Syndrome/drug therapy , Cushing Syndrome/pathology , Dichlorodiphenyldichloroethane/administration & dosage , Dog Diseases/blood , Dog Diseases/diagnosis , Dog Diseases/pathology , Dogs , Female , Hydrocortisone/blood , Male , Pituitary Gland/pathology , Pituitary Neoplasms/pathology , Remission, SpontaneousSubject(s)
Anemia, Hemolytic/veterinary , Anti-Infective Agents, Urinary/adverse effects , Cat Diseases/chemically induced , Heinz Bodies , Methylene Blue/adverse effects , Anemia, Hemolytic/blood , Anemia, Hemolytic/chemically induced , Animals , Anti-Infective Agents, Urinary/therapeutic use , Blood Cell Count , Blood Transfusion , Cat Diseases/blood , Cat Diseases/drug therapy , Cats , Cystitis/drug therapy , Cystitis/veterinary , Erythrocytes/enzymology , Female , Hematocrit , Hemoglobins/analysis , Male , Methylene Blue/therapeutic use , Urinary Calculi/drug therapy , Urinary Calculi/veterinarySubject(s)
Adrenal Insufficiency/veterinary , Dog Diseases , 17-Ketosteroids/urine , Adrenal Insufficiency/diagnosis , Adrenal Insufficiency/drug therapy , Animals , Blood Cell Count , Blood Proteins/analysis , Blood Urea Nitrogen , Corticosterone/blood , Desoxycorticosterone/therapeutic use , Dog Diseases/diagnosis , Dog Diseases/drug therapy , Dogs , Electrocardiography/veterinary , Electrolytes/blood , Female , Hematocrit , Hemoglobins/analysis , Hydrocortisone/blood , Male , Pituitary-Adrenal Function Tests/veterinary , Prednisolone/therapeutic useABSTRACT
The 8 dogs with glomerulonephritis in this study had progressive renal disease characterized by proteinuria, azotemia and hypoalbuminemia, without peripheral edema and ascites. Observed by light, fluorescence and electron microscopy, the glomeruli were diffusely but irregularly involved. By light microscopy, there was focal mesangial proliferation, and the peripheral portions of many glomerular capillary loops were thickened by eosinophilic material along the endothelial sides of basement membranes. Immunofluorescence studies demonstrated granular deposits of IgG and beta1C-globulin outlining glomerular basement membranes and within the mesangium. Ultrastructurally, there were electron-dense deposits in the mesangium and within the endothelial side of glomerular basement membranes. Subepithelial deposits were never seen. The majority of clinical and morphologic features suggested a glomerulonephritis of immune-complex type. However, the unique aspects of the ultrastructural lesion precluded this assumption based solely on morphologic criteria.
