Subject(s)
Carcinoma, Squamous Cell/radiotherapy , Fast Neutrons , Head and Neck Neoplasms/radiotherapy , Neutrons , Radiation Injuries , Taste Disorders/etiology , Adolescent , Adult , Aged , Anorexia/etiology , Child , Fast Neutrons/adverse effects , Female , Gamma Rays , Humans , Male , Middle Aged , Neutrons/adverse effects , Relative Biological Effectiveness , Taste Threshold/radiation effects , Time Factors , Xerostomia/etiologyABSTRACT
Computerized tomography is useful in radiotherapy treatment planning in the following ways: (1) Its image provides the most accurate possible contour of the patient and demonstrates the internal structures in their proper relation to each other. (2) The tumor and its extension are accurately demonstrated. (3) Corrections for tissue heterogeneities can be accomplished in one of two ways, either by arbitrary assignment of densities to tissues or by direct scanning with a therapy source. This latter procedure is under investigation. (4) The computer can be programmed to demonstrate summations of dose delivered from multiple fields.
Subject(s)
Neoplasms/radiotherapy , Radiotherapy Planning, Computer-Assisted , Radiotherapy, Computer-Assisted , Tomography, X-Ray Computed , Dose-Response Relationship, Radiation , Humans , Neoplasms/diagnostic imaging , Tomography Scanners, X-Ray ComputedABSTRACT
From July 1969 to December 1972 a clinical trial was carried out to determine the effects of radiotherapy and chemotherapy individually or in combination on lung cancer. During the first three years of the study 53 of 234 patients underwent curative resection. III of the remaining patients were inoperable and were suitable for inclusion in the study. The patients were randomly assigned to four groups: 1) observation only, 2) chemotherapy (Hydroxyurea) only, 3) radiotherapy only, or 4) combination chemotherapy and radiotherapy. There were no differences in survival in any of the treated groups.
