1.
J Org Chem
; 78(21): 10588-95, 2013 Nov 01.
Article
in English
| MEDLINE
| ID: mdl-24079664
ABSTRACT
A highly convergent and stereocontrolled synthesis of epothilone D (4) is reported. Key features are a cheap and Z-selective synthesis of the northern half based on nerol and acetoacetate and chromium(II)-mediated Reformatsky reactions as a powerful tool for chemoselective asymmetric carbon-carbon bond formations, including an unusual stereospecific macroaldolization.
Subject(s)
Aldehydes/chemistry , Epothilones/chemical synthesis , Macrolides/chemical synthesis , Chromium/chemistry , Epothilones/chemistry , Macrolides/chemistry
2.
ChemMedChem
; 5(3): 361-6, 2010 Mar 01.
Article
in English
| MEDLINE
| ID: mdl-20112329