ABSTRACT
The authors studied the effect of dialysate buffer composition on the serum lipid values in male patients undergoing maintenance hemodialysis. Twenty patients on acetate and 21 patients on bicarbonate hemodialysis were investigated. The serum concentrations of high-density lipoprotein (HDL)-, HDL2- and HDL3-cholesterol were significantly lower in patients on acetate than in those on bicarbonate dialysis. The results of this study suggest possible adverse effects of acetate hemodialysis on serum HDL-cholesterol compared with bicarbonate hemodialysis. Other possibly contributory factors such as age and time on dialysis could be excluded. However, a possible role of differences in drug therapy between acetate- and bicarbonate-treated dialysis patients could not be entirely excluded.
Subject(s)
Acetates/pharmacology , Bicarbonates/pharmacology , Cholesterol, HDL/blood , Renal Dialysis , Acetates/adverse effects , Adult , Cholesterol/blood , Cholesterol, LDL/blood , Humans , Male , Middle Aged , Triglycerides/bloodABSTRACT
The concentrations of cholesterol in the high density lipoprotein (HDL) fraction and the HDL2 and HDL3 subclasses were compared in 333 male renal transplant recipients, 36 male patients on maintenance hemodialysis, and 43 healthy men. The subclasses were separated by a precipitation method using polyethylene glycol 6000 and dextran sulphate. In hemodialyzed patients, total HDL cholesterol and both subclasses were reduced. In renal transplant recipients, both total HDL cholesterol and HDL2 were normal, whereas HDL3 remained reduced, analogous to hemodialyzed patients. It can be concluded that a successful renal transplantation has a beneficial effect on HDL metabolism and thus on the development of atherosclerosis.
