1.
J Antimicrob Chemother
; 47(5): 671-4, 2001 May.
Article
in English
| MEDLINE
| ID: mdl-11328782
ABSTRACT
Cationic cholic acid derivatives displayed potent and broad-spectrum activity against multidrug-resistant Gram-negative and -positive bacteria. Specific examples were effective permeabilizers of the outer membranes of many strains of multidrug-resistant Gram-negative bacteria and sensitized these to hydrophobic antibiotics. We also prepared a new cholic acid derivative with improved apparent selectivity for prokaryote membranes.