Subject(s)
Acute Kidney Injury/etiology , Kidney Neoplasms/complications , Lymphoma/complications , Acute Kidney Injury/diagnosis , Aged , Diagnosis, Differential , Disease Progression , Female , Humans , Kidney/diagnostic imaging , Kidney Neoplasms/diagnosis , Lymphoma/diagnosis , Radiography , Radionuclide Imaging , UltrasonographyABSTRACT
The aim of this study was to investigate infectious complications in renal transplant recipients (RTRs) receiving mycophenolate mofetil (MMF) for prevention of acute transplant rejection. A group of RTRs (n = 47) receiving 1.0-2.0 g/day of MMF with cyclosporine A (CsA) and prednisolone to maintain immunosuppression was compared with a group (n = 47) taking triple immunosuppressive therapy including azathioprine. In both groups the etiology and incidence of infections were evaluated. During 2 years post-transplant, various infections developed in 72.3% of patients who received MMF and in 93.6% of those who received azathioprine. The incidence of viral infections was 53.2% in the MMF group and 59.6% in the azathioprine group and the incidence of bacterial infection was 55.3% and 70.2%, respectively There were two cases of active tuberculosis in the azathioprine group and one in the MMF group. MMF 1.0-2.0 g/day does not increase infection rates in RTRs compared with azathioprine.
Subject(s)
Bacterial Infections/epidemiology , Immunosuppressive Agents/adverse effects , Kidney Transplantation , Mycophenolic Acid/analogs & derivatives , Virus Diseases/epidemiology , Azathioprine/adverse effects , Bacterial Infections/microbiology , Cyclosporine/adverse effects , Drug Therapy, Combination , Female , Humans , Male , Mycophenolic Acid/adverse effects , Prednisolone/adverse effects , Virus Diseases/virologyABSTRACT
This study contains data obtained from a cytogenetic investigation of six patients with acute and chronic leukaemia. The karyotypes of bone marrow or blood cells of these patients showed a partial or complete trisomy for the long arm of chromosome 1. Three observations revealed a pronounced resistance of cell clones with 1q+ towards cytostatic therapy, and a comparatively short life span of patients after detection of 1q+. The importance of these changes for the role of some chromosomes and chromosome loci in leukaemogenesis is discussed.
