ABSTRACT
An apparatus to determine the rate of release of chemotherapeutics from vehicles was developed. It consists of a semi-permeable chamber within a larger glass chamber. The semi-permeable chamber has direct contact with milk within the glass chamber. Preliminary evaluation for rapidity of release of chemotherapeutics by vehicles, in decreasing amount of antibiotic released, showed them to be water, sesame oil, sweet cream butter, peanut oil with aluminum monostearate, lanolin and petrolatum.
ABSTRACT
Extracts of 28 plants were tested without demonstable antiviral activity in an agar-overlay plaque-reduction antiviral assay system, using infectious bovine rhinotracheitis virus and bovine endocardial cell cultures. Ethanolic extract of Narcissus tazetta L bulb elicited antiviral activity by inhibition of viral plaque formation. Antiviral activity was demonstrated against infectious bovine rhinotracheitis and equine rhinopneumonitis viruses. Narcissus tazetta L bulb did not directly inactivate the virus extracellularly. The extract exhibited only limited toxicity to rapidly multiplying bovine endocardial cells at plaque-inhibitory levels and was not cytoxic to preformed confluent cell monolayers. Narcissus extract did not induce the formation of drug-resistant viral strains.
Subject(s)
Herpesvirus 1, Bovine/drug effects , Plant Extracts/pharmacology , Cells, Cultured , Herpesvirus 1, Bovine/growth & development , Herpesvirus 1, Equid/drug effects , Herpesvirus 1, Equid/growth & developmentABSTRACT
Extracts from more than 325 different plants have been tested for their effects on larvae of Aedes aegypti, and from these initial tests, 16 plants were selected for further study. Extracts from plant parts of these 16 plants were screened using tlc and the results are tabulated along with the observed biological activity.
