Subject(s)
Cardiovascular Diseases/prevention & control , Health Promotion , Aspirin/therapeutic use , Brazil , Evidence-Based Medicine , Female , Humans , Hypertension/prevention & control , Meta-Analysis as Topic , Quality of Life , Randomized Controlled Trials as Topic , Risk Assessment , Risk Factors , Treatment OutcomeSubject(s)
Female , Humans , Cardiovascular Diseases/prevention & control , Health Promotion , Aspirin/therapeutic use , Brazil , Evidence-Based Medicine , Hypertension/prevention & control , Meta-Analysis as Topic , Quality of Life , Randomized Controlled Trials as Topic , Risk Assessment , Risk Factors , Treatment OutcomeABSTRACT
PURPOSE: To study the short and long-term follow-up of patients with left main coronary artery disease (LMCAD) and age over 65 years, by comparing the results with patients under 65 years-old. METHODS: Twenty-two patients with LMCAD and mean age of 69 +/- 3.5 years (group I) were underwent isolated coronary artery bypass grafting (CABG) and compared to 31 patients with LMCAD, mean age of 54 +/- 7 years (group II), who also underwent isolated CABG. The life-table Kaplan-Meyer method was used to estimate the post-operative survival. The chi-square and Student "t" test were used when necessary. RESULTS: Despite higher operative mortality in group I (9.1% x 3.2%), the difference was statistically not significant. The operative morbidity was similar in both groups. Actuarial survival at 4 years was 85% in group I and 95% in group II. Actuarial survival free of cardiac events was 69% in group II and 75% in group II. CONCLUSION: The CABG is well tolerated and had low morbidity and acceptable mortality in old patients with LMCAD. The long-term survival in these patients was very similar to the younger patients.
Subject(s)
Coronary Disease/surgery , Myocardial Revascularization , Actuarial Analysis , Adult , Age Factors , Aged , Female , Follow-Up Studies , Humans , Male , Middle Aged , Myocardial Revascularization/adverse effects , Survival AnalysisSubject(s)
Exercise Test , Hypertension/drug therapy , Verapamil/therapeutic use , Adult , Aged , Blood Pressure/drug effects , Electrocardiography , Female , Humans , Hypertension/physiopathology , Male , Middle AgedABSTRACT
Vinte e cinco pacientes participaram de estudo aberto comparativo entre o uso do verapamil e do metoprolol associados a clortalidona no tratamento da hipertensao arterial de grau leve ou moderado. O prazo de uso de cada esquema medicamentoso foi de 15 dias, sendo a avaliacao terapeutica realizada por analise da curva de pressao arterial nos testes cicloergometricos, feitos ao final de cada etapa. No inicio da fase de testes e entre o uso de cada associacao decorreram 15 dias sem uso de qualquer droga. Tanto o verapamil quanto o metoprolol, associados a clortalidona, revelaram eficacia terapeuticas em 100% dos casos com normalizacao nao so da pressao arterial basal como dos valores de esforco em mais de 70% dos casos. Pouco significativa foi a diferenca entre a acao dos dois esquemas terapeuticos, variando apenas o comportamento da frequencia cardiaca e a presenca de para-efeitos propios
Subject(s)
Verapamil , Chlorthalidone , Metoprolol , Hypertension , Exercise TestABSTRACT
Vinte e nove pacientes com hipertensao arterial leve e/ou moderada, nao tratados ou sem uso de medicacao por prazo minimo de 90 dias, foram submetidos a 3 testes ergometricos com avaliacao de curva de pressao arterial. O primeiro teste foi realizado sem uso de qualquer substancia, caracterizando-se a presenca do quadro hipertensivo. No segundo e terceiro testes, foram administrados, alternadamente aos pacientes, verapamil em dose unica de 120 a 360 mg por via oral e placebo, 2 horas antes da prova, sendo medida a PA a cada 60 s durante o decorrer do esforco e repouso posterior. O verapamil teve efeito hipotensor significativo em 63% dos pacientes, em 29% nao houve qualquer modificacao da curva tensional nos 3 testes; 8% dos pacientes tiveram diminuicao de seus niveis tensionais com placebo. Sao analisados ainda os para-efeitos da droga, resultados gerais dos testes ergometricos e a validade do metodo na avaliacao da terapeutica anti-hipertensiva