Perspective Taking and Memory for Self- and Town-Related Information in Male Adolescents and Young Adults.

Adolescence is a sensitive period for categorical self-concept development, which affects the ability to take others' perspectives, which might differ from one's own, and how self-related information is memorized. Little is known about whether these two processes are related in adolescence. The current study recruited 97 male participants aged 11-35 years. Using a self-referential memory task, we found that younger participants were less prone to recognize previously seen town-related adjectives, compared to self-related adjectives. However, this age-related reduction in recognition bias was unrelated to accurate memory performance. Using the Director task to assess perspective taking, we found an age-related decrease in egocentric biases in perspective taking from adolescence to early adulthood (i.e., perspective taking abilities improved with age). However, there was no evidence that these two processes were related. Overall, our findings suggest that male adolescents display parallel but independent age-related changes in self-referential biases in memory and perspective taking.

Child maltreatment and victimization.

It is estimated that up to 25% of all children growing up worldwide experience child maltreatment, making it a global emergency with substantial individual and public health consequences. This chapter addresses one of the most societally pervasive consequences of child maltreatment which is known as the "cycle of victimization." This concept depicts the increased risk of maltreated individuals to victimize others later in life, both within and outside the family environment. To understand the architecture of this victimization cycle, the chapter further sheds light on neurocognitive mechanisms aiding different forms of victimization and the buffering role of social support that could help break the cycle of victimization. Advancing our understanding of these complex and interrelated mechanisms will ultimately facilitate the design and implementation of more targeted early treatments and (preventive) interventions and support a move toward a safer society.

Resilient functioning is associated with altered structural brain network topology in adolescents exposed to childhood adversity.

Childhood adversity is one of the strongest predictors of adolescent mental illness. Therefore, it is critical that the mechanisms that aid resilient functioning in individuals exposed to childhood adversity are better understood. Here, we examined whether resilient functioning was related to structural brain network topology. We quantified resilient functioning at the individual level as psychosocial functioning adjusted for the severity of childhood adversity in a large sample of adolescents (N = 2406, aged 14-24). Next, we examined nodal degree (the number of connections that brain regions have in a network) using brain-wide cortical thickness measures in a representative subset (N = 275) using a sliding window approach. We found that higher resilient functioning was associated with lower nodal degree of multiple regions including the dorsolateral prefrontal cortex, the medial prefrontal cortex, and the posterior superior temporal sulcus (z > 1.645). During adolescence, decreases in nodal degree are thought to reflect a normative developmental process that is part of the extensive remodeling of structural brain network topology. Prior findings in this sample showed that decreased nodal degree was associated with age, as such our findings of negative associations between nodal degree and resilient functioning may therefore potentially resemble a more mature structural network configuration in individuals with higher resilient functioning.

Local and global reward learning in the lateral frontal cortex show differential development during human adolescence.

Reward-guided choice is fundamental for adaptive behaviour and depends on several component processes supported by prefrontal cortex. Here, across three studies, we show that two such component processes, linking reward to specific choices and estimating the global reward state, develop during human adolescence and are linked to the lateral portions of the prefrontal cortex. These processes reflect the assignment of rewards contingently to local choices, or noncontingently, to choices that make up the global reward history. Using matched experimental tasks and analysis platforms, we show the influence of both mechanisms increase during adolescence (study 1) and that lesions to lateral frontal cortex (that included and/or disconnected both orbitofrontal and insula cortex) in human adult patients (study 2) and macaque monkeys (study 3) impair both local and global reward learning. Developmental effects were distinguishable from the influence of a decision bias on choice behaviour, known to depend on medial prefrontal cortex. Differences in local and global assignments of reward to choices across adolescence, in the context of delayed grey matter maturation of the lateral orbitofrontal and anterior insula cortex, may underlie changes in adaptive behaviour.

A practical guide for researchers and reviewers using the ABCD Study and other large longitudinal datasets.

As the largest longitudinal study of adolescent brain development and behavior to date, the Adolescent Brain Cognitive Development (ABCD) Study® has provided immense opportunities for researchers across disciplines since its first data release in 2018. The size and scope of the study also present a number of hurdles, which range from becoming familiar with the study design and data structure to employing rigorous and reproducible analyses. The current paper is intended as a guide for researchers and reviewers working with ABCD data, highlighting the features of the data (and the strengths and limitations therein) as well as relevant analytical and methodological considerations. Additionally, we explore justice, equity, diversity, and inclusion efforts as they pertain to the ABCD Study and other large-scale datasets. In doing so, we hope to increase both accessibility of the ABCD Study and transparency within the field of developmental cognitive neuroscience.

The importance of friendships in reducing brain responses to stress in adolescents exposed to childhood adversity: a preregistered systematic review.

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later life psychopathology. One way through which CA confers such vulnerability in later life is through increased sensitivity to and likelihood of social stress. A growing body of research demonstrates the positive impact of adolescent friendship support on mental well-being after CA; however, the mechanisms that may underlie this relationship are unknown. Neurobiological models of social buffering suggest that social support can reduce perceptions, reactions, and physiological responses to and after stress. Therefore, this preregistered, systematic literature search examined whether friendships reduce neural stress responses in adolescents with CA.