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1.
Data Brief ; 47: 108902, 2023 Apr.
Article in English | MEDLINE | ID: mdl-36747980

ABSTRACT

A thorough characterization of base materials is the prerequisite for further research. In this paper, the characterization data of the reference materials (CEM I 42.5 R, limestone powder, calcined clay and a mixture of these three components) used in the second funding phase of the priority program 2005 of the German Research Foundation (DFG SPP 2005) are presented under the aspects of chemical and mineralogical composition as well as physical and chemical properties. The data were collected based on tests performed by up to eleven research groups involved in this cooperative program.

2.
Data Brief ; 30: 105524, 2020 Jun.
Article in English | MEDLINE | ID: mdl-32322637

ABSTRACT

Two types of cements were selected as the reference cement in the priority program 2005 of the German Research Foundation (DFG SPP 2005). A thorough characterization of CEM I 42.5 R has been made in a recent publication [1]. In this paper, the characterization data of the other reference cement CEM III/A 42.5 N are presented from the aspects of chemical and mineralogical compositions as well as physical and chemical properties. The characterization data of the slag, which is the second main constituent of this specific cement besides the clinker, are presented independently. For all data received, the mean values and the corresponding errors were calculated. The data shall be used for the ongoing research within the priority program. Also, researchers from outside this priority program can benefit from these data if the same materials are used.

3.
Data Brief ; 27: 104699, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31720343

ABSTRACT

A thorough characterization of starting materials is the precondition for further research, especially for cement, which contains various phases and presents quite a complex material for fundamental scientific investigation. In the paper at hand, the characterization data of the reference cement CEM I 42.5 R used within the priority program 2005 of the German Research Foundation (DFG SPP 2005) are presented from the aspects of chemical and mineralogical compositions as well as physical and chemical properties. The data were collected based on tests conducted by nine research groups involved in this cooperative program. For all data received, the mean values and the corresponding errors were calculated. The results shall be used for the ongoing research within the priority program.

4.
Eur J Pharm Biopharm ; 131: 224-231, 2018 Oct.
Article in English | MEDLINE | ID: mdl-30149060

ABSTRACT

Antisolvent precipitation of poorly water-soluble drugs is a promising formulation technique to synthesize amorphous nanoparticles. The dissolution behavior of these nanoparticles is improved because of the high specific surface area and the amorphous state, leading to an enhanced bioavailability of the drug molecules. Nevertheless, stabilization of precipitated drug nanoparticles against agglomeration and recrystallization, which constitutes a key issue for further processing steps, has turned out to be a major challenge. For that reason, the present study presents a synthesis method to produce long-term stable amorphous ibuprofen nanoparticles via antisolvent precipitation. To reach this goal, a new precipitation method was developed: antisolvent melt precipitation (AMP). Formulation strategies (e.g. varying fraction of stabilizer) as well as process parameters (e.g. temperature) were under study to estimate their influence on particle size, size distribution, crystallinity, morphology and stability of synthesized drug nanoparticles.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/chemistry , Ibuprofen/chemistry , Algorithms , Crystallization , Drug Compounding , Drug Stability , Nanoparticles , Particle Size , Solubility , Solvents , Temperature
5.
Arch Microbiol ; 175(1): 1-7, 2001 Jan.
Article in English | MEDLINE | ID: mdl-11271415

ABSTRACT

Mucoralean fungi (Zygomycota) are used for many industrial processes and also as important model organisms for investigating basic biological problems. Their genetic analysis is severely hampered by low transformation frequencies, by their strong tendency towards autonomous replication of plasmids instead of stable integration, and by the lack of reliable genetic reporter systems. We constructed plasmids for transforming the model zygomycete Absidia glauca that carry the versatile reporter gene coding for green fluorescent protein (GFP). gfp expression is controlled either by the homologous actin promoter or the promoter for the elongation factor of translation, EF1alpha. These plasmids also confer neomycin resistance and carry one of two genetic elements (rag1, seg1) that improve mitotic stability of the plasmid. The gfp constructs were replicated extrachromosomally and could be recovered from retransformed Escherichia coli cells. gfp expression was monitored by epifluorescence microscopy. The gfp reporter gene plasmids presented here for the model zygomycete A. glauca constitute the first reliable system that allows the monitoring of gene expression in this important group of fungi.


Subject(s)
Absidia/genetics , Genes, Reporter , Luminescent Proteins/genetics , Absidia/metabolism , Blotting, Southern , Escherichia coli/genetics , Gene Expression , Genetic Vectors , Green Fluorescent Proteins , Luminescent Proteins/biosynthesis , Microscopy, Fluorescence , Peptide Elongation Factor 1/genetics , Plasmids/genetics , Recombinant Proteins/biosynthesis , Transformation, Genetic
7.
Planta ; 71(2): 184-8, 1966 Jun.
Article in German | MEDLINE | ID: mdl-24554015

ABSTRACT

Through an actionspectrum it has been shown that light affects the membrane potential of the alga Acetabularia crenulata by way of the chloroplasts.

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