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3.
Ciba Found Symp ; 101: 147-64, 1983.
Article in English | MEDLINE | ID: mdl-6360586

ABSTRACT

In an attempt to determine the role of vitamin E in retrolental fibroplasia (RLF) we report our experience with 191 infants of less than 1500 g birth weight. Of these infants, 16.75% had evidence of acute RLF in hospital, 8.4% had cicatricial RLF at follow-up, and four infants (2.1%) were blind, none of whom had received supplementary vitamin E. The incidence of cicatricial RLF at follow-up was significantly lower in infants who received vitamin E early after birth (12 h) than in those who did not (3 of 105 versus 13 of 86, X2 = 9.26, P = 0.002), as was the incidence of Grade III or greater cicatrix (0 of 105 versus 7 of 86, X2 with Yates = 6.72, P = 0.01). Stepwise multiple linear regression analysis revealed three factors distinguishing infants who developed cicatricial RLF from those who did not: the lack of early vitamin E supplements (P = 0.0023), the significantly larger number of arterial PO2 values over 100 mmHg (P = 0.0056), and the presence of an intraventricular haemorrhage (P = 0.0032). The incidence and severity of necrotizing enterocolitis was similar in infants who received vitamin E and in those who did not. It is recommended that vitamin E be given within the first 12 hours of birth to all infants of less than 1500 g who require supplementary oxygen.


Subject(s)
Retinopathy of Prematurity/prevention & control , Vitamin E/therapeutic use , Administration, Oral , Blindness/prevention & control , Clinical Trials as Topic , Humans , Infant, Low Birth Weight , Infant, Newborn , Injections, Intramuscular , Oxygen Inhalation Therapy/adverse effects , Vitamin E/administration & dosage , Vitamin E/blood
4.
Lancet ; 1(8281): 1087-91, 1982 May 15.
Article in English | MEDLINE | ID: mdl-6122890

ABSTRACT

126 appropriate-for-gestational age neonates born in hospital with birth-weights of 750 g-1500 g were prospectively studied in a randomised trial to determine the effect of intramuscular vitamin E on the frequency and severity of retrolental fibroplasia (RLF). In the 99 who lived for more than one month the frequency of active RLF in the vitamin E and control groups in the nursery (18.8% vs 23.5%) and at discharge (8.3% vs 19.6% was not significantly different. Vitamin E had significantly reduced the severity of RLF at follow-up eye examination 6-33 months after discharge (p less than 0.01). 3 control infants (760 g, 780 g, 1020 g) were blind in both eyes (grade V cicatricial RLF), whereas the most severe grade of disease in the vitamin E infants was grade II cicatrix. Infants in whom RLF developed were gestationally younger (p = 0.005), required a longer period of mechanical ventilation (p = 0.035), had a greater exposure to oxygen (p = 0.03), and had a greater number of arterial PO2 values between 75 and 99 mm Hg (p = 0.004). Early administration of vitamin E, while not affecting the frequency of RLF, will significantly reduce its severity and subsequent eye damage, and such treatment is recommended for all low-birth-weight infants of less than 1250 g who require supplementary oxygen.


Subject(s)
Retinopathy of Prematurity/drug therapy , Vitamin E/administration & dosage , Acute Disease , Birth Weight , Blindness/prevention & control , Clinical Trials as Topic , Female , Follow-Up Studies , Humans , Infant, Newborn , Injections, Intramuscular , Male , Random Allocation , Vitamin E/blood
5.
Can J Ophthalmol ; 10(3): 305-18, 1975 Jul.
Article in English | MEDLINE | ID: mdl-1148902

ABSTRACT

Seven cases of hemangioma of the optic disc are presented. A survey of the literature is summarized and the differential diagnosis and appropriate management discussed.


Subject(s)
Eye Neoplasms , Hemangioma , Optic Disk , Optic Nerve , Adult , Angiomatosis/diagnosis , Child , Diagnosis, Differential , Eye Neoplasms/diagnosis , Female , Fluorescein Angiography , Fundus Oculi , Hemangioma/diagnosis , Hemangioma, Cavernous/diagnosis , Humans , Light Coagulation , Male , Middle Aged , Retinal Vessels , Syndrome , Vision Disorders/etiology , Xenon
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