1.
Arzneimittelforschung
; 36(8): 1157-61, 1986 Aug.
Article
in German
| MEDLINE
| ID: mdl-2946303
ABSTRACT
The absolute configuration of (+)-celiprolol ([alpha]D = +6.3 degrees in CHCl3) was established by a 9-step synthesis via the (+) (R)-acetonide of (R)-glyceraldehyde. This result was confirmed by the Cupra-A CD-spectra of the isopropyl and hydroxy analogs. The enantiomeric purity was determined by NMR analysis of the diastereomeric amide esters obtained by reaction of celiprolol with 2 mol of alpha-methoxy-alpha-trifluoromethyl-phenylacetic acid chloride (Mosher's reagent).