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1.
J Pediatr Surg ; 54(10): 2038-2043, 2019 Oct.
Article in English | MEDLINE | ID: mdl-30898400

ABSTRACT

PURPOSE: "Early on-ECMO" repair of CDH entails repair within 48-72 h of cannulation in an effort to optimize pulmonary physiology, shorten ECMO duration, and, ultimately, improve survival. This study evaluated the effect of early on-ECMO repair as compared to leaving patients unrepaired during ECMO. METHODS: The CDH Study Group database was queried for CDH patients requiring ECMO who either underwent repair within the first 72 h after cannulation or remained unrepaired on ECMO. Primary outcomes were survival to decannulation and ECMO duration. RESULTS: A total of 248 patients underwent early repair and 922 remained unrepaired on ECMO. The early repair group had increased risk factors for poor outcomes, including higher odds of cardiac defects and thoracic liver location, and lower odds of hernia sac presence. Nonetheless, ECMO survival for the early repair group was 87.1% compared to 78.4% in the unrepaired group (p = 0.002). However, the early repair group had a longer median ECMO duration than the unrepaired group (240.6 vs 196.8 h, p = 0.001). CONCLUSION: While early ECMO repair does not shorten ECMO duration, it results in increased survival to decannulation as compared to those unrepaired on ECMO. This suggests that there may be a physiologic benefit leading to increased ECMO survival in a subset of patients undergoing on-ECMO repair over those designated to undergo post-ECMO repair. LEVEL OF EVIDENCE: Level III.


Subject(s)
Extracorporeal Membrane Oxygenation , Hernias, Diaphragmatic, Congenital , Extracorporeal Membrane Oxygenation/mortality , Extracorporeal Membrane Oxygenation/statistics & numerical data , Hernias, Diaphragmatic, Congenital/mortality , Hernias, Diaphragmatic, Congenital/surgery , Humans , Infant, Newborn , Retrospective Studies
2.
Pediatr Surg Int ; 34(7): 721-726, 2018 Jul.
Article in English | MEDLINE | ID: mdl-29808279

ABSTRACT

PURPOSE: Optimal timing of congenital diaphragmatic hernia (CDH) repair in patients requiring extracorporeal membrane oxygenation (ECMO) remains controversial. The "late ECMO repair" is an approach where the patient, once deemed stable for decannulation, is repaired while still on ECMO to enable expeditious return to ECMO if surgery induces instability. The goal of this study was to investigate the potential benefit of this approach by evaluating the rate of return to ECMO after repair. METHODS: The CDH Study Group database was used to analyze CDH patients requiring ECMO support. The primary outcome was return to ECMO within 72 h of CDH repair among those repaired following ECMO decannulation ("post-ECMO" patients). Secondary outcomes were death within 72 h of repair and cumulative death and return to ECMO rate. RESULTS: A total of 668 patients were repaired post-ECMO decannulation. Six patients (0.9%) in the post-ECMO group required return to ECMO within 72 h of surgery and a total of 19 (2.8%) died or returned to ECMO within 72 h of surgery. CONCLUSION: The rate of return to ECMO and death following CDH repair is extremely low and does not justify the risks inherent to "on-ECMO" repair. Patients stable to come off ECMO should undergo repair after decannulation.


Subject(s)
Extracorporeal Membrane Oxygenation , Hernias, Diaphragmatic, Congenital/surgery , Diaphragm/surgery , Female , Herniorrhaphy/methods , Humans , Infant, Newborn , Male , Registries , Retrospective Studies , Treatment Outcome
3.
J Laparoendosc Adv Surg Tech A ; 28(6): 774-779, 2018 Jun.
Article in English | MEDLINE | ID: mdl-29641364

ABSTRACT

INTRODUCTION: Thoracoscopic repair of congenital diaphragmatic hernia (CDH) has been associated with faster recovery, earlier extubation, and decreased morbidity. Nevertheless, thoracoscopic repair is rarely attempted in the post-extracorporeal membrane oxygenation (ECMO) patient. Commonly cited reasons for not attempting thoracoscopy include concerns that the patients' respiratory status is too tenuous to tolerate insufflation pressures or that presumed defect size is so large that it precludes thoracoscopic repair. Our purpose is to review our experience with post-ECMO thoracoscopic CDH repair and evaluate the success of this approach. METHODS: We performed retrospective analysis of attempted thoracoscopic CDH repairs after ECMO decannulation at our institution from 2001 to 2015. Primary outcome was rate of conversion. Secondary outcomes were intraoperative end-tidal CO2, time to extubation, and rate of recurrence. RESULTS: We identified 21 post-ECMO patients in whom thoracoscopic CDH repair was attempted. Thoracoscopic repair was successfully completed in 28%. No patients had reported intolerance to insufflation at 3-7 mmHg. Average end-tidal CO2 at 15 operative minutes was 36.9 mmHg in the thoracoscopic group versus 50.7 mmHg in the open group and at 60 minutes was 34.25 mmHg versus 45.6 mmHg, respectively. One patient in the thoracoscopic group died and 1 experienced a large pneumothorax. In the converted group there was one clinically significant pneumothorax and three pleural effusions. Survivors after thoracoscopy were extubated an average of 5.6 ± 2.6 days after surgery versus 19.4 ± 10 days in the converted group (P < .05). Recurrence rates at last follow-up were equal between the two groups at 20%. CONCLUSIONS: Thoracoscopic CDH repair is both safe and feasible after ECMO with no increase in operative morbidity or mortality. Insufflation pressures of 3-7 mmHg are well tolerated without undue increase in end-tidal CO2. When compared to conversion cases, thoracoscopic repair is associated with significantly decreased time to extubation with no difference in recurrence.


Subject(s)
Extracorporeal Membrane Oxygenation/adverse effects , Hernias, Diaphragmatic, Congenital/surgery , Herniorrhaphy/methods , Thoracoscopy/methods , Airway Extubation/statistics & numerical data , Conversion to Open Surgery/statistics & numerical data , Feasibility Studies , Herniorrhaphy/adverse effects , Humans , Infant, Newborn , Recurrence , Retrospective Studies , Thoracoscopy/adverse effects , Treatment Outcome
4.
J Laparoendosc Adv Surg Tech A ; 28(4): 476-480, 2018 Apr.
Article in English | MEDLINE | ID: mdl-29297742

ABSTRACT

PURPOSE: The appearance of the diaphragmatic curvature and the rib insertion level of the diaphragm on postoperative chest X-ray (CXR) may predict recurrence. Our purpose was to examine the relationship between the curvature of the diaphragm on postoperative CXR and recurrence. METHODS: We performed a retrospective review of left-sided, Bochdalek congenital diaphragmatic hernia (CDH) surgical repairs from 2004 to 2015 at a single institution. We developed a tool to measure the flatness of the diaphragm on postoperative CXR, termed the diaphragmatic curvature index (τ). The primary outcome of interest was recurrence after surgical repair. RESULTS: Of the 127 patients identified, 54% (n = 69) had a primary repair, while 46% (n = 58) required a patch repair. The overall recurrence rate was 21.3% (n = 27). There was no difference in median lateral rib insertion level in patients with and without recurrence or those who had a primary or patch repair. The overall median diaphragmatic curvature index was 6.29 (interquartile range [IQR] 5.30-8.09) and was not significantly different among patients who had a recurrence (6.00, IQR 5.34-8.24) and those who did not (6.46, IQR 5.24-8.07) (P = .853). Within the primary repair group (6.34 versus 6.93, P = .84) and the patch repair group (5.59 versus 6.18, P = .46), the median diaphragmatic curvature index was not different among patients who had a recurrence and those who did not. CONCLUSIONS: A flat appearance of the diaphragm on postoperative CXR as measured by the median diaphragmatic curvature index (τ) is not associated with recurrence. The shape of the diaphragm on CXR after CDH repair may not be predictive of recurrence as previously thought.


Subject(s)
Diaphragm/diagnostic imaging , Hernias, Diaphragmatic, Congenital/surgery , Diaphragm/surgery , Female , Herniorrhaphy , Humans , Infant, Newborn , Male , Postoperative Period , Predictive Value of Tests , Radiography, Thoracic , Recurrence , Retrospective Studies , Ribs/diagnostic imaging , Treatment Outcome
5.
J Laparoendosc Adv Surg Tech A ; 28(5): 606-609, 2018 May.
Article in English | MEDLINE | ID: mdl-29237145

ABSTRACT

INTRODUCTION: There is little consensus on optimal management for congenital diaphragmatic hernia extracorporeal membrane oxygenation (CDH ECMO) patients. Meaningful comparisons of the various approaches have been limited due to the low number of cases in institutions. In addition, the multidisciplinary reliance and rigid institutional framework of ECMO serve to further limit exposure to alternative practices. The goal of this study is to survey the international pediatric surgery community to describe the current practice trends. METHODS: A survey was electronically distributed to the international pediatric surgical community. The results were evaluated using statistical analysis. RESULTS: A total of 123 pediatric surgeons completed the survey, of whom 89% work at institutions offering both venoatrial (VA) and venovenous (VV) ECMO. Although 69% perform VA ECMO for CDH, only 46% felt VA was the "optimal method." Among VV proponents, 21% believe the rate of VV to VA conversion to be <5% and 16% believe it to be >30% compared with 0% and 40% in VA proponents. Distribution of timing of repair: 46% post-ECMO repair, 22% early ECMO repair, 15% whenever stabilized on ECMO, and 14% late ECMO repair. Sixty-four percent (71/111) would perform an ECMO CDH repair in the unweanable patient and 27% (30/111) report successful decannulation after repair of a patient who was unweanable on ECMO for 2 weeks. Ninety-two percent do not perform exit-to-ECMO. CONCLUSION: There are significant practice variations in the management of CDH ECMO. Majority of pediatric surgeons perform VA ECMO in CDH patients; however, a significant percentage of those believe VV to be more optimal. This discrepancy is not accounted for by the VA-only institutions. Although post-ECMO CDH repair is the most common approach, the majority would perform a repair "on ECMO" if the patient was unweanable. In addition, although many pediatric surgeons believe the "last ditch repair" for the unweanable patient to be futile, 27% have reported success. Exit-to-ECMO for CDH remains a minority practice.


Subject(s)
Extracorporeal Membrane Oxygenation/methods , Hernias, Diaphragmatic, Congenital/surgery , Pediatrics/statistics & numerical data , Practice Patterns, Physicians' , Surgeons/statistics & numerical data , Humans , Retrospective Studies , Surveys and Questionnaires , Survival Rate
6.
J Laparoendosc Adv Surg Tech A ; 27(3): 311-317, 2017 Mar.
Article in English | MEDLINE | ID: mdl-28051921

ABSTRACT

PURPOSE: Postoperative pneumothorax and effusion remain a concern following congenital diaphragmatic hernia (CDH) repair. Despite a recent trend away from intraoperative thoracostomy, few studies have actually compared outcomes with and without a chest tube. Rationale commonly cited for the more minimalistic approach include the presumed low likelihood of postoperative complications, potential risk of patch infection, and prolonged intubation. We evaluate these theories, as well as the implications of intraoperative chest tube (IOCT) placement. METHODS: We performed a retrospective chart review of 174 patients who underwent CDH repair at our academic children's hospital from 2004 to 2015. We compared incidence of clinically significant pleural events between patients who received an IOCT (n = 49) and those who did not (NIOCT, n = 124). We also evaluated time to extubation and rate of patch infections. RESULTS: Clinically significant pneumothorax or effusion occurred in 28% of NIOCT patients versus 10% of IOCT patients (P = .01). After thoracoscopic repair, time to extubation averaged 5.2 days in IOCT patients, 5.4 days in NIOCT patients with no postoperative complications, and 6.4 days in NIOCT patients requiring postoperative intervention. After open repair, time to extubation averaged 13.8, 13.6, and 22.5 days, respectively. There were no documented patch infections. CONCLUSIONS: Chest tube placement during CDH repair is associated with significantly lower incidence of clinically significant pleural complications, does not delay extubation, and results in shorter ventilator times than cases that require postoperative intervention. Patch infections are extremely rare. There is no evidence that chest tube placement increases this risk.


Subject(s)
Hernias, Diaphragmatic, Congenital/surgery , Herniorrhaphy , Pleural Effusion/prevention & control , Pneumothorax/prevention & control , Postoperative Complications/prevention & control , Thoracostomy , Chest Tubes , Female , Follow-Up Studies , Humans , Incidence , Infant , Infant, Newborn , Male , Pleural Effusion/epidemiology , Pleural Effusion/etiology , Pneumothorax/epidemiology , Pneumothorax/etiology , Postoperative Complications/epidemiology , Retrospective Studies , Risk Assessment , Thoracostomy/instrumentation , Treatment Outcome
7.
J Laparoendosc Adv Surg Tech A ; 26(11): 925-929, 2016 Nov.
Article in English | MEDLINE | ID: mdl-27705081

ABSTRACT

PURPOSE: Although recurrence remains one of the most feared complications following congenital diaphragmatic hernia (CDH) repair, there are minimal data on the optimal surgical approach to these complex situations. The purpose of this study was to survey the international pediatric surgery community to ascertain practice patterns for both minimally invasive (MIS) and open approaches for recurrent CDH. MATERIALS AND METHODS: A survey was e-mailed to members of an online community of pediatric surgeons. The questionnaire elicited surgeons' clinical experience, the continent in which they practice, and their surgical approach (laparotomy, thoracotomy, laparoscopy, or thoracoscopy) to five clinical cases, including initial and recurrent Bochdalek hernias. Fisher's exact test and chi-square test were used for statistical analysis. RESULTS: Two-hundred eighty pediatric surgeons responded to the survey. In total, 52.1% of surgeons chose an MIS approach for an initial repair of left CDH with the younger surgeons more likely to use an MIS approach. For the recurrence scenarios, 42.5%-55.5% of these surgeons would attempt an MIS repair after a recurrence. Specifically, thoracoscopy was favored over laparoscopy following both prior laparotomy (30.0% versus 7.5%) and prior right thoracoscopy (26.4% versus 10.0%), less favored following thoracotomy (9.3% versus 18.9%), and relatively similar proportions following prior left thoracoscopy (17.5% versus 16.4%). Laparotomy was the preferred open approach both for initial presentation and all recurrence scenarios. Among surgeons who would treat initial CDH with an open procedure, between 10.4% and 17.9% would switch to an MIS approach, most commonly after prior failed laparotomy. CONCLUSIONS: Approximately half surgeons who approach initial left CDH in an MIS manner would attempt an MIS approach for recurrence. The tendency to approach CDH recurrence from the opposite body cavity as the initial repair clearly impacted the surgical approach. This was particularly pronounced for MIS repairs, whereas for open approach, laparotomy remained, by far, the most popular in all scenarios.


Subject(s)
Hernias, Diaphragmatic, Congenital/surgery , Herniorrhaphy/methods , Pediatrics , Practice Patterns, Physicians' , Surgeons , Humans , Laparoscopy/methods , Laparotomy/methods , Minimally Invasive Surgical Procedures , Recurrence , Reoperation , Surveys and Questionnaires , Thoracoscopy/methods , Thoracotomy/methods
8.
J Pediatr Surg ; 51(2): 260-3, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26681348

ABSTRACT

AIM: We present our technique for construction of the "Omega Jejunostomy" (OJ), a novel method of postpyloric feeding using a pouched-jejunal loop capable of accommodating a balloon gastrostomy button. We describe potential indications for the procedure and outcomes in a complex patient population. MATERIALS AND METHODS: We retrospectively reviewed records of patients who underwent an OJ at our institution between 2005 and 2014. Primary outcomes include operating time, length of hospital stay, time to feeding goals, and postoperative complications. RESULTS: We identified 12 children (6 males) with multiple comorbidities who underwent OJ procedures. The median age at surgery was 11years (range 3months-23years). Eleven patients had failed previous alternative feeding access or antireflux procedures. All patients eventually reached their feeding goals. Eight were at goal feeds in <10days. Two achieved goal feeds <1month, one <4months, and one within 7months. There was one OJ failure because of fistula formation requiring surgical revision, and one child was treated successfully but died of unrelated causes. Four children eventually transitioned to PO or G-tube feeds, and six were tolerating feeds via OJ at last follow-up (8-74months). CONCLUSIONS: OJ provides a durable alternative to gastrojejunostomy tube for patients who are poor candidates for or have failed Nissen fundoplication. It is technically easier to perform than a gastroesophageal disconnect procedure, has minimal surgical comorbidities, and can provide durable feeding access and achievement of goal feeds in a complex and refractory patient subset.


Subject(s)
Enteral Nutrition/methods , Gastroesophageal Reflux/surgery , Intubation, Gastrointestinal/methods , Jejunostomy/methods , Adolescent , Child , Child, Preschool , Enteral Nutrition/instrumentation , Female , Follow-Up Studies , Gastroesophageal Reflux/therapy , Humans , Infant , Intubation, Gastrointestinal/instrumentation , Jejunostomy/instrumentation , Length of Stay/statistics & numerical data , Male , Operative Time , Outcome Assessment, Health Care , Postoperative Complications/epidemiology , Retrospective Studies , Young Adult
9.
J Laparoendosc Adv Surg Tech A ; 25(9): 782-5, 2015 Sep.
Article in English | MEDLINE | ID: mdl-26287392

ABSTRACT

BACKGROUND: Total proctocolectomy (TPC) and ileal pouch anal anastomosis (IPAA) have become the standard of care for patients with ulcerative colitis refractory to medical management. The purpose of our study is to show our single-site approach and to identify maneuvers that improve efficiency. MATERIALS AND METHODS: We retrospectively reviewed patients who underwent single-site three-stage TPC-IPAA for ulcerative colitis at our institution. Primary outcomes included operative time, conversion from single site to standard laparoscopy, time to oral intake and stoma function, postoperative complications, and length of stay. The GelPOINT(™) Advanced Access Platform (Applied Medical, Santa Margarita, CA) was used. RESULTS: Eight patients were identified who had undergone single-site surgery with the GelPOINT platform. Six of the 8 patients underwent the first stage, total abdominal colectomy (TAC), and all 8 underwent the second stage (proctectomy/IPAA). The mean operating time for TAC was 242 ± 32 minutes. The mean time until tolerance of clear diet was 1.2 ± 0.4 days, and time until tolerance of regular diet was 3.3 ± 1.2 days. The mean time to stoma function was 1.5 ± 0.55 days, and that for postoperative opioid use was 4.0 ± 1.3 days. The median length of stay was 5 days (range, 3-10 days). There was one postoperative complication. The mean operating time for the proctectomy/IPAA was 283 ± 50 minutes. The mean time until tolerance of clear diet was 1.0 ± 0.5 days, and time until tolerance of regular diet was 3.3 ± 1.1 days. The mean time to stoma function was 1.6 days ± 0.52 days, and that for postoperative opioid use was 3.3 ± 1.4 days. Median length of stay was 4 days (range, 3-9 days). There was one postoperative complication. Technical adaptations that included extracorporeal mesenteric division, rectal eversion, and rotation of the GelPOINT device served to improve the ease and efficiency of the procedure. CONCLUSIONS: Single-site TPC-IPAA is both feasible and safe. Incorporation of adapted technical maneuvers can increase efficiency.


Subject(s)
Colitis, Ulcerative/surgery , Proctocolectomy, Restorative/methods , Adolescent , Child , Female , Humans , Length of Stay , Male , Operative Time , Postoperative Complications , Retrospective Studies , Treatment Outcome
10.
Surg Innov ; 21(5): 464-8, 2014 Oct.
Article in English | MEDLINE | ID: mdl-24368399

ABSTRACT

BACKGROUND: Laparoendoscopic single-site sleeve gastrectomy is gaining acceptance. However, totally natural orifice translumenal endoscopic surgery (NOTES) in morbidly obese patients is still controversial due to safety and technical issues. To this end, we have developed a technique for sleeve gastrectomy in which the surgical field view is achieved through transgastric approach and the operating channel will eventually be through the vagina to form a dual lumen totally NOTES procedure for sleeve gastrectomy. As a step toward this approach, we performed a single abdominal incision in order to simulate the transvaginal route. This study is another step toward combined transvaginal and transgastric totally NOTES sleeve gastrectomy. METHODS AND PROCEDURES: A combined NOTES and single trocar sleeve gastrectomy was performed on 8 porcine animal models. The endoscope was inserted through the gastric wall and served as the vision source for the procedure. A second endoscope was inserted via the transabdominal trocar together with the surgical instruments. RESULTS: Sleeve gastrectomy was performed on 8 porcine models. The operative time for the first procedure was 5 hours, but after determining the technique, the time was reduced by half. CONCLUSION: Combined NOTES and single trocar sleeve gastrectomy is feasible in a porcine model. We achieved an excellent view of the surgical field through the transgastric approach. We believe that in the near future, combining the transgastric visualization of the surgical field together with a transvaginal approach may enable performing a total NOTES sleeve gastrectomy procedure. This hypothesis will be studied in further animal experiments before implementation in humans.


Subject(s)
Gastrectomy/methods , Laparoscopy/methods , Natural Orifice Endoscopic Surgery/methods , Animals , Stomach/surgery , Swine
11.
J Laparoendosc Adv Surg Tech A ; 22(10): 984-8, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23190043

ABSTRACT

OBJECTIVE: Natural orifice translumenal endoscopic surgery (NOTES) and single-port surgery (SPS) have maximized the enhanced aesthetic profile of laparoscopic surgery. Nevertheless, these modalities also accentuate the inherent limitations of subvisibility and decreased instrument dexterity of motion. The goal of this study was to evaluate the utility of a miniature laparoscopic camera to alleviate these obstacles. MATERIALS AND METHODS: A miniature laparoscopic camera was inserted via an endoscopic working channel or embedded into laparoscopic tools. Following laparoscopic trainer studies, operations were conducted on pigs using standard laparoscopic, SPS, and NOTES approaches. Additionally, the camera was used to perform colonoscopies on mice, rats, and pigs. RESULTS: The camera enabled visualizing the dissection area behind the renal vessels during laparoscopic nephrectomy and in the Triangle of Calot in laparoscopic cholecystectomy while providing accurate and detailed visualization of the operative field. The camera was successfully passed through the working channel of a standard gastroscope and used during NOTES procedures. It was used during colonoscopy to evaluate the distal colon in pigs and allowed the diagnosis of small colonic polyps with good image quality. Additionally, it could be easily passed beyond colonic strictures created in a porcine model. Finally, its miniature size enabled performance of colonoscopies on rats serving as animal models for colonic polyps. CONCLUSIONS: The miniature laparoscopic camera provides adequate images with enhanced visibility in conventional laparoscopic, SPS, and NOTES procedures. We believe that this device or similar miniature cameras may greatly aid the future development of NOTES and SPS by enhancing the safety and ease of performing these procedures. Further development is being conducted in order to integrate this camera into standard instruments and to allow an even better image quality.


Subject(s)
Colonoscopy/instrumentation , Laparoscopy/instrumentation , Miniaturization , Natural Orifice Endoscopic Surgery/instrumentation , Animals , Equipment Design
12.
J Laparoendosc Adv Surg Tech A ; 21(9): 797-801, 2011 Nov.
Article in English | MEDLINE | ID: mdl-21942360

ABSTRACT

OBJECTIVE: One of the most significant limitations of laparoscopic surgery is the inability to achieve tactile assessment of structures during surgical dissection. Because blood vessels are naturally warmer than their surroundings, infrared (IR) detection can be highly effective in identifying and mapping out their course. In recent years, IR detection has been used successfully for this purpose in open surgery. Nevertheless, this technology has to be yet employed in laparoscopic surgery, where its contribution would be greatest. METHODS: We performed a feasibility study using this technology on live porcine models. After insertion of IR detectors into the insufflated abdomen, we performed a series of laparoscopic procedures. During these operations we evaluated the ability of the IR detector to identify blood vessels as well as the effects of local and systemic changes in temperature. RESULTS: The IR detector successfully identified concealed blood vessels as well as acute bleeding. Cool lavage and insufflation with room-temperature CO(2) accentuated IR detection of blood vessels, whereas warm CO(2) and systemic temperature changes did not affect detection. Additionally, localized heating of tissue on the operative field using electrocautery did not interfere with IR sensitivity. CONCLUSION: Laparoscopic IR imaging is a feasible method of blood vessel detection in laparoscopic procedures. Use of IR blood vessel detection in laparoscopy has a potential to enable safer surgery and reduce operative time. Fusion of IR imaging with the standard laparoscopic view is currently being developed to allow real-time vessel mapping during laparoscopic procedures.


Subject(s)
Blood Vessels/anatomy & histology , Infrared Rays , Laparoscopy/methods , Animals , Feasibility Studies , Swine
13.
Harefuah ; 150(1): 25-8, 69, 2011 Jan.
Article in Hebrew | MEDLINE | ID: mdl-21449152

ABSTRACT

In the past, abdominal surgery mandated a large abdominal wall incision. The minimal invasive surgery techniques including Laparoscopy, created an option for performing intraabdominal surgery through small incisions. In this article, the authors present new surgical techniques: the natural orifice trans-luminal endoscopic surgery (NOTES], and the singLe incision laparoscopic surgery (SILS). It seems that these evolving techniques are the third generation of surgery.


Subject(s)
Abdomen/surgery , Laparoscopy/methods , Natural Orifice Endoscopic Surgery/methods , Humans , Minimally Invasive Surgical Procedures/methods
14.
Microsurgery ; 31(1): 66-71, 2011 Jan.
Article in English | MEDLINE | ID: mdl-20734435

ABSTRACT

INTRODUCTION: Discovery of enhanced glucose tolerance following bariatric surgery has sparked renewed interest in the investigation of unchartered underlying pathways of glucose homeostasis. Delineation of this pathway may ultimately be the first step in the creation of a novel therapy for type II diabetes. Nevertheless, the technical complexity and formidable nature of these surgeries coupled with the fragile nature of small rodents has made the creation of a mouse model to study these effects incredibly challenging. We have created a simplified sleeve gastrectomy mouse model to study the effects of bariatric surgery on glucose tolerance and beta cell proliferation. METHODS: Nineteen mice were randomized to undergo either sleeve gastrectomy (SG) (9) or sham operation (SH) (10). Weight and serum glucose were measured three times weekly and serum insulin measurements and pancreatic harvest were performed at the time of sacrifice. Five mice from each group were sacrificed after one week and the remainder sacrificed after one month. RESULTS: Survival of mice was 100% for both groups. The SG group demonstrated an initial drop in weight and serum glucose as compared to SH, which normalized by one month following surgery. Serum insulin levels and rate of beta cell proliferation were similar in both groups after one week and one month. CONCLUSION: The simplified sleeve gastrectomy is a technically straightforward, low-mortality technique for creating a bariatric mouse model which most faithfully replicates bariatric surgery performed in humans. This model can be a valuable tool to investigate the glucose tolerance and beta cell effects of bariatric surgery.


Subject(s)
Blood Glucose/metabolism , Diabetes Mellitus , Gastrectomy/methods , Animals , Cell Proliferation , Diabetes Mellitus/metabolism , Homeostasis/physiology , Immunohistochemistry , Insulin-Secreting Cells/metabolism , Islets of Langerhans/metabolism , Islets of Langerhans/pathology , Mice , Models, Animal , Weight Loss/physiology
16.
Cell Biochem Biophys ; 58(3): 157-61, 2010 Dec.
Article in English | MEDLINE | ID: mdl-20725802

ABSTRACT

Erythrocyte adhesion to the vascular endothelium is one of the key determinants of microcirculatory blood flow. Adhesion is a complex process determined by the intricate interaction among red blood cells (RBC), plasma factors, and the vascular endothelium. Rats are commonly used as disease models to investigate the pathophysiology of various hematological disease processes occurring in humans and their response to prospective treatments. The aim of our study was to characterize the adhesion of RBC in adult blood from rat and human subjects, in order to test the validity of rat models for adhesion-related disease processes. We demonstrated that adhesion of RBC from rats (rRBC), to endothelial cells (EC) in plasma-free buffer, is stronger than from human subjects (hRBC). In addition, plasma proteins induced elevation of hRBC (eightfold) but depression of rRBC (threefold) adhesion to EC. It is thus suggested to be aware of the difference in RBC/EC interaction for human and rat subjects, when studying models of blood flow.


Subject(s)
Blood Proteins/metabolism , Endothelial Cells/physiology , Erythrocytes/physiology , Animals , Cell Adhesion/physiology , Cells, Cultured , Endothelium, Vascular/cytology , Erythrocytes/cytology , Humans , Models, Animal , Phosphatidylserines/metabolism , Rats , Rats, Sprague-Dawley
17.
J Laparoendosc Adv Surg Tech A ; 20(5): 465-8, 2010 Jun.
Article in English | MEDLINE | ID: mdl-20565303

ABSTRACT

Benign acquired esophagorespiratory fistulas (BERFs) represent a broad spectrum of anatomic pathology presenting in a wide variety of clinical settings. These fistulas can lead to severe respiratory compromise and rarely close spontaneously. Surgical fistula closure has been the traditional therapeutic approach, but is associated with significant morbidity and mortality. The recent advent of endoscopic technologies suggests that minimally invasive procedures may offer a safe alternative to surgery for the treatment of esophagorespiratory fistulas. In this article, we present our experience in treating complex benign esophagorespiratory fistulas of diverse etiologies utilizing a primarily minimal invasive, endoscopic, or combined surgical and endoscopic approaches. Our experience demonstrates that an endoscopic-based approach is safe and technically feasible and can, potentially, spare a subset of patients from open surgery. A multidisciplinary decision-making process, based on individualized parameters, is a prerequisite for a successful outcome.


Subject(s)
Bronchial Fistula/surgery , Digestive System Surgical Procedures/adverse effects , Diverticulum, Esophageal/surgery , Esophageal Fistula/surgery , Pleural Diseases/surgery , Adult , Bronchial Fistula/etiology , Cutaneous Fistula/etiology , Cutaneous Fistula/surgery , Endoscopy , Esophageal Fistula/etiology , Feasibility Studies , Humans , Laser Coagulation , Lasers, Gas , Male , Middle Aged , Pleural Diseases/etiology , Reoperation
18.
Ann Vasc Surg ; 24(5): 693.e1-4, 2010 Jul.
Article in English | MEDLINE | ID: mdl-20471785

ABSTRACT

We report a case of iatrogenic resection of both the superior mesenteric artery (SMA) and celiac artery during left nephrectomy and adrenalectomy. A 47-year-old woman was diagnosed with a large adrenal tumor and underwent a laparoscopic left adrenalectomy that was converted to open adrenalectomy and nephrectomy as a result of a bulky tumor. Both the SMA and celiac artery were inadvertently cut at their origin because of adherence of the tumor to the aorta. Both arteries were revascularized by anastomosing the distal splenic artery to the aorta after performing splenectomy to revascularize the celiac circulation and using an autologous saphenous vein graft to revascularize the SMA. The patient had no postoperative complications. To our knowledge, this is the first description of use of the splenic artery for celiac revascularization.


Subject(s)
Adrenal Gland Neoplasms/surgery , Adrenalectomy/adverse effects , Celiac Artery/surgery , Mesenteric Artery, Superior/surgery , Nephrectomy/adverse effects , Saphenous Vein/transplantation , Splenic Artery/transplantation , Anastomosis, Surgical , Celiac Artery/diagnostic imaging , Celiac Artery/injuries , Female , Humans , Iatrogenic Disease , Mesenteric Artery, Superior/diagnostic imaging , Mesenteric Artery, Superior/injuries , Middle Aged , Tomography, X-Ray Computed , Treatment Outcome
19.
World J Gastroenterol ; 16(13): 1670-2, 2010 Apr 07.
Article in English | MEDLINE | ID: mdl-20355248

ABSTRACT

We present the case of an 18-year-old female transferred to our center from an outside hospital due to persistent gastrointestinal bleeding. Two weeks prior to her transfer she underwent duodenal omentopexy for a perforated duodenal peptic ulcer. The patient underwent a computed tomography angiogram which identified the source of bleeding as a giant gastro-duodenal artery (GDA) pseudoaneurysm. The patient was taken to interventional radiology where successful microcoil embolization was performed. We present this rare case of a giant GDA pseudoaneurysm together with imaging and a review of the medical literature regarding prevalence, etiology and treatment options for visceral arterial aneurysms.


Subject(s)
Aneurysm, False/diagnosis , Aneurysm, False/pathology , Angiography/methods , Digestive System Surgical Procedures/adverse effects , Gastrointestinal Hemorrhage/diagnosis , Peptic Ulcer/surgery , Adolescent , Embolization, Therapeutic , Female , Humans , Peptic Ulcer/complications , Postoperative Complications , Risk , Treatment Outcome
20.
Surg Endosc ; 24(6): 1486-9, 2010 Jun.
Article in English | MEDLINE | ID: mdl-20054582

ABSTRACT

BACKGROUND: An internal hernia is a protrusion of bowel through a normal or abnormal orifice in the peritoneum or mesentery. Paraduodenal hernia is by far the most common form of congenital internal hernia, making up 53% of all reported cases. In recent years, as surgeons have become more comfortable with laparoscopic techniques, they are performing an increasing number of these procedures laparoscopically. METHODS: To highlight the technical steps of this technique, the case of a patient with a left paraduodenal hernia and a video of the laparoscopic repair are presented. Additionally, a PubMed search of the English medical literature was conducted using the search words "laparoscopic," "paraduodenal," and "hernia" as filters. The cases of laparoscopic paraduodenal hernia repair in the literature to date recording data on technique, complications, and hospital course were reviewed. RESULTS: In addition to the case described in this report, 14 cases of laparoscopic paraduodenal hernia were described in 10 published reports. Of the 15 cases, 11 (73%) were left-sided, likely representing the relative incidence of these cases. The hernia defect was closed in 10 (77%) of the 13 cases for which the repair method was described, whereas the defect was widely opened in the remaining cases. One report described an operative complication (6.7%), an internal mesenteric vein injury, and one recurrence (6.7%) occurred 18 months after surgery in the direct defect closure group. CONCLUSION: The current data lead to the conclusion that laparoscopic paraduodenal hernia repair is a safe and feasible approach for selected patients. It can be expected that as surgeons become increasingly comfortable and facile with laparoscopic techniques, paraduodenal hernias and many other causes of acute small bowel obstruction will be increasingly managed laparoscopically.


Subject(s)
Duodenal Diseases/surgery , Duodenum/abnormalities , Herniorrhaphy , Laparoscopy/methods , Duodenal Diseases/congenital , Duodenal Diseases/diagnostic imaging , Duodenum/surgery , Female , Follow-Up Studies , Hernia/congenital , Hernia/diagnostic imaging , Humans , Middle Aged , Radiography, Abdominal , Tomography, X-Ray Computed , Video Recording
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