1.
Science
; 294(5543): 849-52, 2001 Oct 26.
Article
in English
| MEDLINE
| ID: mdl-11679669
ABSTRACT
Listeria monocytogenes is a food-borne pathogen with a high mortality rate that has also emerged as a paradigm for intracellular parasitism. We present and compare the genome sequences of L. monocytogenes (2,944,528 base pairs) and a nonpathogenic species, L. innocua (3,011,209 base pairs). We found a large number of predicted genes encoding surface and secreted proteins, transporters, and transcriptional regulators, consistent with the ability of both species to adapt to diverse environments. The presence of 270 L. monocytogenes and 149 L. innocua strain-specific genes (clustered in 100 and 63 islets, respectively) suggests that virulence in Listeria results from multiple gene acquisition and deletion events.
Subject(s)
Bacterial Proteins/genetics , Genome, Bacterial , Listeria monocytogenes/genetics , Listeria/genetics , Adaptation, Physiological , Amino Acid Motifs , Bacillus subtilis/genetics , Bacterial Proteins/chemistry , Bacterial Proteins/physiology , Base Composition , Carrier Proteins/chemistry , Carrier Proteins/genetics , Chromosomes, Bacterial/genetics , DNA, Bacterial/chemistry , DNA, Bacterial/genetics , Gene Transfer, Horizontal , Genes, Bacterial , Genomics , Listeria/chemistry , Listeria/physiology , Listeria monocytogenes/chemistry , Listeria monocytogenes/pathogenicity , Listeria monocytogenes/physiology , Membrane Proteins/chemistry , Membrane Proteins/genetics , Sequence Analysis, DNA , Staphylococcus aureus/genetics , Transcription Factors/chemistry , Transcription Factors/genetics , Virulence/genetics
2.
Ohio State Med J
; 80(8): 610-3, 1984 Aug.
Article
in English
| MEDLINE
| ID: mdl-6462600
Subject(s)
Splenectomy , Humans , Middle Aged , Morbidity , Ohio , Postoperative Complications , Retrospective Studies , Splenectomy/adverse effects , Splenectomy/mortality
3.
Pac Med Surg
; 75(5): 306-14, 1967.
Article
in English
| MEDLINE
| ID: mdl-6060301
Subject(s)
Lung Neoplasms/pathology , Lymph Nodes/pathology , Adult , Biopsy , Female , Humans , Lymphatic Metastasis , Male , Microtomy , Middle Aged
4.
Am J Surg
; 111(2): 247-8, 1966 Feb.
Article
in English
| MEDLINE
| ID: mdl-5903697