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1.
Sportverletz Sportschaden ; 23(4): 210-6, 2009 Dec.
Article in German | MEDLINE | ID: mdl-20108185

ABSTRACT

BACKGROUND: There is abundant literature on the treatment of Achilles tendon rupture; however data on sports and recreational activities after this injury is scarce. PATIENTS AND METHODS: 71 patients were assessed in a prospective cross-sectional study after an average of 3 years after Achilles tendon rupture. 44 patients were treated non-operatively, using a functional algorithm, and 23 patients were treated operatively. Outcome parameters were the AOFAS-Score and the SF-36 Score. The strength of plantar-flexion was measured using the Isomed 2000 system, the structural integrity of the tendon was assessed sonografically. RESULTS: Patients treated operatively had a higher complication rate than patients treated non-operatively (p = 0.05). Re-rupture rate was identically in both groups. No difference was noted between the two groups for the AOFAS score (92 vs. 90). Moreover the SF-36 score did not show any significant difference between the groups. However, if compared to the age-adjusted normative population significant lower scores were achieved. A significant reduction in practicing sports was detected, as well as a reduction of plantar flexion of the affected foot (p = 0.04). CONCLUSION: Except for complication rate no significant difference could be detected between the groups. Thus operative treatment in the recreational athlete should only be considered, if no adaptation of the ends of the tendon is diagnosed during the initial or repeated ultrasound. Regardless of the therapeutic intervention chosen an Achilles tendon rupture leads to marked changes in sports- and recreational activities.


Subject(s)
Achilles Tendon/injuries , Achilles Tendon/surgery , Activities of Daily Living , Athletic Injuries/surgery , Motor Activity , Postoperative Complications/etiology , Sports , Adult , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Recovery of Function , Recreation , Rupture , Treatment Outcome , Young Adult
2.
Aliment Pharmacol Ther ; 29(1): 104-14, 2009 Jan.
Article in English | MEDLINE | ID: mdl-18801055

ABSTRACT

BACKGROUND: A sensation of abdominal swelling (bloating) and actual increase in girth (distension) are troublesome features of irritable bowel syndrome (IBS), which is more common in patients with constipation, especially those with delayed transit. AIM: To establish whether a fermented dairy product containing Bifidobacterium lactis DN-173 010 reduces distension in association with acceleration of gastrointestinal transit and improvement of symptoms in IBS with constipation. METHODS: A single centre, randomized, double-blind, controlled, parallel group study in which patients consumed the test product or control product for 4 weeks. Distension, orocaecal and colonic transit and IBS symptoms were assessed on an intention-to-treat population of 34 patients. RESULTS: Compared with control product, the test product resulted in a significant reduction in the percentage change in maximal distension [median difference - 39%, 95% CI (-78, -5); P = 0.02] and a trend towards reduced mean distension during the day [-1.52 cm (-3.33, 0.39); P = 0.096]. An acceleration of orocaecal [-1.2 h (-2.3,0); P = 0.049] as well as colonic [-12.2 h (-22.8, -1.6); P = 0.026] transit was observed and overall symptom severity [-0.5 (-1.0, -0.05); P = 0.032] also improved. CONCLUSIONS: This probiotic resulted in improvements in objectively measured abdominal girth and gastrointestinal transit, as well as reduced symptomatology. These data support the concept that accelerating transit is a useful strategy for treating distension.


Subject(s)
Bifidobacterium , Constipation/diet therapy , Cultured Milk Products , Dilatation, Pathologic/diet therapy , Irritable Bowel Syndrome/diet therapy , Probiotics/therapeutic use , Adult , Aged , Analysis of Variance , Constipation/complications , Constipation/physiopathology , Dilatation, Pathologic/complications , Double-Blind Method , Female , Gastrointestinal Transit/physiology , Humans , Irritable Bowel Syndrome/complications , Middle Aged , Severity of Illness Index , Time Factors , Treatment Outcome , Young Adult
3.
J Appl Physiol (1985) ; 94(6): 2282-8, 2003 Jun.
Article in English | MEDLINE | ID: mdl-12736190

ABSTRACT

Myosin heavy chain (MHC) isoform expression changes with physical training. This may be one of the mechanisms for muscular adaptation to exercise. We aimed to investigate the effects of different strength-training protocols on MHC isoform expression, bearing in mind that alpha- MHC(slow) (newly identified MHC isoform) mRNA may be upregulated in response to training. Twelve volunteers performed a 6-wk strength training with maximum contractions (Max group), and another 12 of similar age performed combination training of maximum contractions and ballistic and stretch-shortening movements (Combi group). Muscle samples were taken from triceps brachii before and after training. MHC isoform composition was determined by SDS-PAGE silver staining, and mRNA levels of MHC isoforms were determined by RT-PCR. In Max group, there was an increase in MHC(2A) (49.4 to 66.7%, P < 0.01) and a decrease in MHC(2X) (33.4 to 19.5%, P < 0.01) after training, although there was no significant change in MHC(slow). In Combi group, there was also an increase in MHC(2A) (47.7 to 62.7%, P < 0.05) and a decrease in MHC(slow) (18.2 to 9.2%, P < 0.05) but no significant change in MHC(2X). An upregulation of alpha-MHC(slow) mRNA was, therefore, found in both groups as a result of training. The strength training with maximum contractions led to a shift in MHC isoform composition from 2X to 2A, whereas the combined strength training produced an MHC isoform composition shift from slow to 2A.


Subject(s)
Muscle, Skeletal/metabolism , Myosin Heavy Chains/metabolism , Physical Education and Training , Adult , Humans , Male , Myosin Heavy Chains/genetics , Protein Isoforms/genetics , Protein Isoforms/metabolism , RNA, Messenger/metabolism
4.
J Strength Cond Res ; 15(3): 284-9, 2001 Aug.
Article in English | MEDLINE | ID: mdl-11710652

ABSTRACT

The aim of this study was to compare the effects of single-set and multiple-set strength training in women. Twenty-seven women (aged 20-40 years) with basic experience in strength training were randomly allocated to either a single-set group (n = 9), a 3-set group (n = 9), or a nontraining control group (n = 9). Both training groups underwent a whole-body strengthening program, exercising 2 days a week for 6 weeks. Exercises included bilateral leg extension, bilateral leg curl, abdominal crunch, seated hip adduction/abduction, seated bench press, and lateral pull-down. The single-set group's program consisted of only 1 set of 6-9 repetitions until failure, whereas the multiple-set group trained with 3 sets of 6-9 repetitions until failure (rest interval between sets, 2 minutes). Two times before and 3 days after termination of the training program, subjects were tested for their 1 repetition maximum strength on the bilateral leg extension and the seated bench press machine. Data were analyzed using a repeated-measures analysis of variance, Scheffé tests, t-tests, and calculation of effect sizes. Both training groups made significant strength improvements in leg extension (multiple-set group, 15%; single-set group, 6%; p 0.05). However, in the seated bench press only the 3-set group showed a significant increase in maximal strength (10%). Calculation of effect sizes and percentage gains revealed higher strength gains in the multiple-set group. No significant differences were found in the control group. These findings suggest superior strength gains occurred following 3-set strength training compared with single-set strength training in women with basic experience in resistance training.


Subject(s)
Exercise/physiology , Physical Education and Training/methods , Adult , Analysis of Variance , Female , Humans , Random Allocation
5.
Sportverletz Sportschaden ; 15(1): 1-7, 2001 Mar.
Article in German | MEDLINE | ID: mdl-11338657

ABSTRACT

To examine the effects of strength training with superimposed vibrations ten subjects trained over a period of six weeks (three sessions per week) one leg with back squats and superimposed vibrations and the other leg with traditional squats. In each training session participants performed 4 sets with 8-12 repetitions. Before and after the training period maximum strength and rate of force development were measured. The results show that both training modes induced comparable and statistical significant increases in maximum strength (vibration training +6.5%, traditional training +6.2%. The slight increases in rate of force development in both groups didn't reach statistical significance. As a consequence it seems that strength training with superimposed vibrations for the leg extensor chain is not superior to a traditional training mode.


Subject(s)
Exercise/physiology , Leg/physiology , Muscle, Skeletal/physiology , Vibration , Adult , Data Interpretation, Statistical , Female , Humans , Male , Time Factors
8.
C R Acad Hebd Seances Acad Sci D ; 280(14): 1713-6, 1975 Apr 14.
Article in French | MEDLINE | ID: mdl-807364

ABSTRACT

Rabbit articular chondrocytes, isolated and incubated in vitro, incorporate tritium-labelled thymidine. Thymidine incorporation is stimulated by normal human serum, this effect being related to serum concentration and increased by addition of poly-DL-ornithine. The stimulatory effect of the serum from hypopituitary dwarfs is low and is not increased by poly-DL-ornithine.


Subject(s)
Cartilage, Articular/drug effects , Somatomedins/pharmacology , Animals , Cells, Cultured , DNA Replication/drug effects , Dose-Response Relationship, Drug , Drug Synergism , Dwarfism, Pituitary/blood , Growth Hormone/physiology , Ornithine/pharmacology , Rabbits , Somatomedins/blood , Stimulation, Chemical , Thymidine/metabolism
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