Subject(s)
Form Perception/physiology , Adaptation, Ocular , Female , Humans , Male , Neural Inhibition , Time FactorsABSTRACT
Blood pressure of adult male SWR/J mice is approximately 20 mm Hg higher than that of females. Castrating males at weaning eliminated this sex difference. Testosterone restored blood pressure of castrated mice to the level of the intact males within 10 days indicating a pressor effect of testosterone. Ovariectomy had no effect on blood pressure.
Subject(s)
Blood Pressure/drug effects , Testosterone/pharmacology , Animals , Body Weight/drug effects , Drug Implants , Female , Male , Mice , Mice, Inbred Strains , Sex Factors , Testis/physiology , Testosterone/administration & dosageABSTRACT
SWR/J female mice, 8 hr water deprived, were injected intraperitoneally with 0, 10, 50, 200, and 800 mU of aqueous pitressin, 5 min prior to presentation of water. Drinking measurements made at 5, 15, 25, and 35 min of the drinking period revealed a significant transient inhibition of drinking for the three highest dosages. Injections had no measureable effect on blood pressure. Only the highest dosage had an effect on gross motor activity, a significant decline.
Subject(s)
Drinking Behavior/drug effects , Vasopressins/pharmacology , Water Deprivation , Animals , Female , Mice , Mice, Inbred Strains , Water Deprivation/drug effectsSubject(s)
Diabetes Insipidus/complications , Drinking Behavior , Sodium Chloride/pharmacology , Taste , Water Deprivation , Animals , Avoidance Learning , Blood Proteins/analysis , Body Weight , Dehydration/complications , Female , Hematocrit , Mice , Mice, Inbred C3H , Mice, Inbred C57BL , Mice, Inbred Strains , Osmolar Concentration , Plasma/analysis , Species Specificity , Time FactorsABSTRACT
The age-dependent polydipsia and polyuria observed in SWR/J mice was found to be caused by relative inability of the kidneys to respond to antidiuretic hormone (ADH), resulting in a concentrating defect, which persisted even following Pitressin injection or water deprivation. Posterior pituitaries contained large amounts of ADH, which was also found in the urine and increased in output following water deprivation, indicating normal, or above normal synthesis and release of ADH. Kidneys of polydipsic SWR/J mice weighed more than those of normal strains and sometimes contained a lesion in the medullary area. No clear relationship was found between the size of the lesion and water intake.
Subject(s)
Diabetes Insipidus/physiopathology , Disease Models, Animal , Kidney Diseases/physiopathology , Animals , Drinking , Female , Kidney Concentrating Ability , Male , Mice , Mice, Inbred Strains , Organ Size , Osmolar Concentration , Pituitary Gland/metabolism , Species Specificity , Vasopressins/metabolism , Vasopressins/urine , Water DeprivationABSTRACT
Gonadectomies were performed at 25 days of life in SWR/J mice, a strain known to develop age-dependent nephrogenic diabetes insipidus with females drinking far more than males. Effect of gonadectomy was different for each of the 3 nonreproductive behaviors studied. (1) Ovariectomy reduced the age-dependent polydipsia seen in females, but castration was without effect in males. (2) Castration of males resulted in a lower intake of an isotonic NaCl solution, making the castrated males similar to the sham-operated and ovariectomized females which did not differ. (3) For the short-term activity measurement sham-operated males did not differ from sham-operated females and castrated males did not differ from ovariectomized females. In each sex, gonadectomy reduced activity.
