ABSTRACT
Gingival recessions can cause severe aesthetical problems, especially when associated with the exposure of the margin of crown or bridge restorations. When complete root coverage can not be achieved by periodontal surgery techniques, prosthetic restorations are usually replaced to improve the aesthetic situation. This clinical report describes the application of a composite repair filling as an alternative technique to correct the restoration margin and cover the exposed root surface. From the published literature it is known that metallic and ceramic surfaces can be repaired adhesively using composite materials. This procedure is less costly and invasive, but provides satisfactorily aesthetic results.
Subject(s)
Composite Resins , Crowns , Dental Prosthesis Repair/methods , Gingival Recession/pathology , Adult , Dental Bonding , Esthetics, Dental , Female , HumansABSTRACT
Claudins are major components of tight junctions and contribute to the epithelial-barrier function by restricting free diffusion of solutes through the paracellular pathway. We have mapped a new locus for recessive renal magnesium loss on chromosome 1p34.2 and have identified mutations in CLDN19, a member of the claudin multigene family, in patients affected by hypomagnesemia, renal failure, and severe ocular abnormalities. CLDN19 encodes the tight-junction protein claudin-19, and we demonstrate high expression of CLDN19 in renal tubules and the retina. The identified mutations interfere severely with either cell-membrane trafficking or the assembly of the claudin-19 protein. The identification of CLDN19 mutations in patients with chronic renal failure and severe visual impairment supports the fundamental role of claudin-19 for normal renal tubular function and undisturbed organization and development of the retina.
