[Initial results in tumor diagnosis with radioactive lanthanide complexes]. / Erste klinische Erfahrungen bei der Tumordiagnostik mit radioaktiven Lanthanid-Komplexen.

Clinical investigations have been made in 70 patients to determine whether 169Yb-labelled metal ligand complexes accumulate in various tumors as was shown by previous animal experiments. The time course of these radiopharmaceuticals in tumors, the skeleton and the liver permitted a good to excellent tumor imaging in 61/70 cases. Even 2-5 h after intravenous injection of the radioactive compound, a meaningful diagnosis could be made in the majority of cases. A number of lesions were found for which no equivalent findings were available with other methods. They were therefore interpreted as metastases.

[Ultrathin-layer starch gel electrophoresis--a method qualified to solve specific problems in enzyme analysis]. / Die Ultradünnschichtstärkegelelektrophorese--ein geeignetes Verfahren zur Lösung spezifischer Probleme der Enzymanalytik.

Particular separation problems of enzymatic analysis led to optimization investigation on starch gel electrophoresis. Investigations on the optimum gel concentration range a well as on the duration of the hydrolysis of starch for a suitable gel network gave rise to a starch level with good molecular sieve effect. Optimization of the electrophoretic buffer system and the development of an optimum technique for manufacturing handy transparent ultra thin-layer starch gels with high selectivity results for a broad spectrum of diagnostically enzymatic systems has turned out to be of advantage for enzymatic electrophoresis.

[Results of functional scintigraphic studies of the hepatobiliary system following reconstruction of bile duct injuries with ring drainage splinting]. / Ergebnisse funktionell-szintigraphischer Untersuchungen des hepatobiliären Systems nach Rekonstruktion von Gallengangs-verletzungen mit Ringdrainageschienung.

Functional-scintigraphic examinations were conducted to establish liver functionality and kinetics of extrahepatic bile flow, using 99mTc-Rotop-Ehida, in 25 patients with bilio-biliary or bilio-digestive anastomosis calibrated by ring drainage. Checks were made with indwelling drainage in place or after its removal. Liver damage was detectable in 80 per cent of all probands. The method based on nuclear medicine has proved to be more suitable for quantitative functionality assessment than clinical examinations and enzyme activity tests. With ring drainage in place, it may provide useful information complementary to X-ray presentation of bile duct conditions. After removal of ring drainage, it should be preferred to invasive methods of examination.

[Demonstration of dual liver systems after experimental auxiliary partial liver transplantation using the alternative of sequential hepatobiliary scintigraphy]. / Die hepatobiliäre Sequenzszintigraphie-Alternative zur Uberprüfung des Duallebersystems nach experimenteller auxiliärer Leberteiltransplantation.

Hepatobiliary sequential scintigraphies by 99m Tc-ROTOP-EHIDA were carried out for judging the dual liver system after experimental auxiliary transplantation of a part of the liver. A functional advantage of the host liver in contrast to the transplant was found in all cases investigated. Ischemic transplant damages could be detected in all experiments and were scintigraphically recognised at an early stage. In addition to transplants with a functioning entire parenchyma, the investigations showed transplants with functionally active parenchyma zones and such ones without any functional evidence. A quantifiable determination of the global functional capacity of the hepatobiliary system of both livers was possible and also the evidence on residual functions. The different behaviour of the kinetics of the radio-pharmacon with normal function and in case of hepatic ischemia is discussed.

[The auxiliary transplantation of a portion of liver in an animal experiment]. / Die auxiliäre Transplantation eines Leberteiles im Tierexperiment.

The authors inform about a model for auxiliary liver part transplantation in pig. Intra-abdominal narrowness which can lead to failure of the transplant can avoided by this model. In the transplant was carried out an extensive left resection with purse-string ligature of all visible vessels and cystic ducts. The resection surface is sealed by a tissue adhesive. An auxiliary transplanted part of the liver can also operate on a heterotopic location of the organism.