Subject(s)
Cyclosporine/therapeutic use , Pyoderma Gangrenosum/drug therapy , Adolescent , Adult , Humans , MaleABSTRACT
After suffering from chronic and steroid-resistant erosive lichen planus of the glans penis for 2 years, a 42-year-old patient presented to our Institute. The clinical picture was of an erythematous and erosive lesion, superficially covered with sero-fibrinous exudations. Lichen planus was diagnosed by clinical and histological examination. Control routine serum analysis and urinalysis gave normal results, and ciclosporin A was given at a dosage of 3 mg/kg daily. After 2 weeks of therapy, significant regression of erythema and infiltration was seen, so that the patient could be circumcised as planned. After leaving our Institute the patient continued the therapy with ciclosporin A and the monthly controls of kidney and liver function had shown no abnormalities during the 6-month follow-up that had elapsed up to the time of writing.
Subject(s)
Cyclosporine/therapeutic use , Lichen Planus/drug therapy , Adult , Biopsy , Dose-Response Relationship, Drug , Drug Administration Schedule , Humans , Lichen Planus/pathology , Male , Skin/pathologyABSTRACT
The cytological modifications of the horny layer cell population in psoriatic subjects during treatment with Cyclosporin A are described. They are studied by means of the cytoexfoliative method. The value of this technique is discussed, using it either for diagnosis, or for evaluating therapeutic efficacy of various treatments. The cytological findings are respectively compared with those of other psoriasis therapies, such as Methotrexate and RO 10-9359 (etretinate).
