ABSTRACT
We discuss German examples where counterfactuals restricting an epistemic modal are embedded under glauben 'believe'. Such sentences raise a puzzle for the analysis of counterfactuals, modals, and belief attributions within possible-worlds semantics. Their truth conditions suggest that the modal's domain is determined exclusively by the subject's belief state, but evaluating the counterfactual separately at each of the subject's doxastic alternatives does not yield the correct quantificational domain: the domain ends up being determined by the facts of each particular world, which include propositions the subject does not believe. We therefore revise the semantics of counterfactuals: counterfactuals still rely on an ordering among worlds that can be derived from a premise set (Kratzer, Angelika. 1978. Semantik der Rede: Kontexttheorie - Modalwörter - Konditionalsätze (Monographien Linguistik und Kommunikationswissenschaft 38). Königstein: Scriptor, 2012 [1981]a. The notional category of modality. In Modals and conditionals (Oxford studies in theoretical linguistics 36), 27-69. Oxford: Oxford University Press), but rather than uniquely characterizing a world, this premise set can be compatible with multiple worlds. In belief contexts, the attitude subject's belief state as a whole determines the relevant ordering. This, in turn, motivates a revision of the semantics of believe: following Yalcin's work on epistemic modals (Yalcin, Seth. 2007. Epistemic modals. Mind 116. 983-1026), we submit that evaluation indices are complex, consisting of a world and an ordering among worlds. Counterfactuals are sensitive to the ordering component of an index. Attitude verbs shift both components, relativizing the ordering to the attitude subject.
ABSTRACT
The massive infiltration of lymphocytes into the skin is a hallmark of numerous human skin disorders. By co-culturing murine keratinocytes with splenic T cells we demonstrate here that T cells affect and control the synthesis and secretion of chemokines by keratinocytes. While pre-activated CD8+T cells induce the synthesis of CXCL9 and CXCL10 in keratinocytes and keep in check the synthesis of CXCL1, CXCL5, and CCL20, keratinocytes dampen the synthesis of CCL3 and CCL4 in pre-activated CD8+T cells. One key molecule is IFN-γ that is synthesized by CD8+T cells under the control of NFATc1 and NFATc2. CD8+T cells deficient for both NFAT factors are unable to induce CXCL9 and CXCL10 expression. In addition, CD8+T cells induced numerous type I IFN-inducible "defense genes" in keratinocytes encoding the PD1 and CD40 ligands, TNF-α and caspase-1. The enhanced expression of type I IFN-inducible genes resembles the gene expression pattern at the dermal/epidermal interface in lichen planus, an inflammatory T lymphocyte-driven skin disease, in which we detected the expression of CXCL10 in keratinocytes in close vicinity to the infiltration front of T cells. These data reflect the multifaceted interplay of lymphocytes with keratinocytes at the molecular level.
