ABSTRACT
PURPOSE: Developmental and epileptic encephalopathies (DEEs) are severe clinical conditions characterized by stagnation or decline of cognitive and behavioral abilities preceded, accompanied or followed by seizures. Because DEEs are clinically and genetically heterogeneous, next-generation sequencing, especially exome sequencing (ES), is becoming a first-tier strategy to identify the molecular etiologies of these disorders. METHODS: We combined ES analysis and international data sharing. RESULTS: We identified 11 unrelated individuals with DEE and de novo heterozygous truncating variants in the interferon regulatory factor 2-binding protein-like gene (IRF2BPL). The 11 individuals allowed for delineation of a consistent neurodevelopmental disorder characterized by mostly normal initial psychomotor development followed by severe global neurological regression and epilepsy with nonspecific electroencephalogram (EEG) abnormalities and variable central nervous system (CNS) anomalies. IRF2BPL, also known as enhanced at puberty protein 1 (EAP1), encodes a transcriptional regulator containing a C-terminal RING-finger domain common to E3 ubiquitin ligases. This domain is required for its repressive and transactivating transcriptional properties. The variants identified are expected to encode a protein lacking the C-terminal RING-finger domain. CONCLUSIONS: These data support the causative role of truncating IRF2BPL variants in pediatric neurodegeneration and expand the spectrum of transcriptional regulators identified as molecular factors implicated in genetic developmental and epileptic encephalopathies.
Subject(s)
Carrier Proteins/genetics , Epilepsy/genetics , Neurodevelopmental Disorders/genetics , Nuclear Proteins/genetics , Seizures/genetics , Adolescent , Adult , Central Nervous System/diagnostic imaging , Central Nervous System/pathology , Child , Electroencephalography , Epilepsy/diagnostic imaging , Epilepsy/physiopathology , Female , Heterozygote , High-Throughput Nucleotide Sequencing , Humans , Male , Middle Aged , Mutation , Neurodevelopmental Disorders/diagnostic imaging , Neurodevelopmental Disorders/physiopathology , Phenotype , Seizures/diagnostic imaging , Seizures/physiopathology , Exome Sequencing , Young AdultABSTRACT
We report the case of a 10-year-old boy with pharmacoresistant epilepsy, symptomatic of a right temporoparietal hemorrhagic lesion, who displayed an eating passion as described for the gourmand syndrome (GS) in adults and discuss the role of epilepsy in GS. This patient presented with a significant change in his eating habits (abnormal preoccupation with the preparation and eating of fine-quality food) concordant with the onset of his seizure disorder, without any previous history of eating disorders or psychiatric illness. This observation corroborates the important role of the right cerebral hemisphere in disturbed eating habits, including the relatively benign GS, and, possibly rarely, in less benign eating disorders such as anorexia and obesity.
Subject(s)
Epilepsy/diagnosis , Feeding and Eating Disorders/diagnosis , Anticonvulsants/therapeutic use , Appetite/physiology , Cerebral Hemorrhage/complications , Cerebral Hemorrhage/physiopathology , Child , Dominance, Cerebral/physiology , Drug Resistance , Epilepsy/drug therapy , Epilepsy/physiopathology , Feeding Behavior/physiology , Feeding and Eating Disorders/drug therapy , Feeding and Eating Disorders/physiopathology , Humans , Male , Neuropsychological Tests , Parietal Lobe/physiopathology , Temporal Lobe/physiopathologyABSTRACT
AIM: The aim of this study was to obtain information about neurological and cognitive outcome for a population-based group of children after paediatric ischaemic stroke. METHODS: Data from the Swiss neuropaediatric stroke registry (SNPSR), from 1.1.2000 to 1.7.2002, including children (AIS 1) and neonates (AIS 2). At 18-24 months after a stroke, a follow-up examination was performed including a history, neurological and neuropsychological assessment. RESULTS: 33/48 children (22 AIS 1, 11 AIS 2) participated in the study. Neurological outcome was good in 16/33. After childhood stroke mean IQ levels were normal (94), but 6 children had IQ < 85 (50-82) and neuropsychological problems were present in 75%. Performance IQ (93) was reduced compared to verbal IQ (101, p = 0.121) due to problems in the domain of processing speed (89.5); auditory short-term memory was especially affected. Effects on school career were common. Outcome was worse in children after right-sided infarction. Children suffering from stroke in mid-childhood had the best prognosis. There was no clear relationship between outcome and localisation of the lesion. After neonatal stroke 7/11 children showed normal development and epilepsy indicated a worse prognosis in the remaining 4. CONCLUSION: After paediatric stroke neuropsychological problems are present in about 75% of children. Younger age at stroke as well as an emergence of epilepsy were predictors for worse prognosis.
Subject(s)
Intelligence/physiology , Mental Processes/physiology , Neuropsychological Tests/statistics & numerical data , Stroke/physiopathology , Adolescent , Age Factors , Brain Infarction/pathology , Brain Infarction/physiopathology , Child , Child, Preschool , Educational Status , Female , Follow-Up Studies , Humans , Intelligence Tests , Male , Outcome Assessment, Health Care , Sex Characteristics , Switzerland/epidemiologyABSTRACT
We report the results of three years of the population-based, prospective Swiss NeuroPaediatric Stroke Registry (SNPSR) of children (up to 16 years) with childhood arterial ischaemic stroke (AIS1), neonatal stroke (AIS2), or symptomatic sinus venous thrombosis (SVT). Data on risk factors (RF), presentation, diagnostic work-up, localisation, and short-term neurological outcome were collected. 80 children (54 males) have been included, 40 AIS1, 23 AIS2, and 17 SVT. The data presented will be concentrated on AIS. The presentation for AIS1 was hemiparesis in 77% and cerebellar symptoms and seizures in 20%, respectively. AIS2 presented in 83% with seizures and in 38% with abnormality of muscle tone. Two or more RF were detected in 54%, one RF in 35%. The most prominent RF for AIS1 were infections (40%), followed by cardiopathies and coagulopathies (25% each). AIS2 were frequently related to birth problems. Neurological outcomes in AIS1 and AIS2 were moderate/severe in 45 % and 32 %, respectively. The outcome correlated significantly with the size of infarction (p = 0.013) and age at stroke (p = 0.027). The overall mortality was 6%. Paediatric stroke is a multiple risk problem, which leads to important long-term sequelae.
Subject(s)
Cohort Studies , Registries , Stroke/epidemiology , Adolescent , Age Factors , Analysis of Variance , Brain Infarction/diagnosis , Child , Child, Preschool , Female , Functional Laterality , History, Ancient , Humans , Incidence , Infant , Magnetic Resonance Imaging/methods , Male , Neurologic Examination/methods , Retrospective Studies , Risk Factors , Stroke/classification , Surveys and Questionnaires , Switzerland/epidemiology , Time FactorsABSTRACT
The authors describe four unrelated girls with a distinctive neurologic disorder with early-onset progressive ataxia and hypodontia with a characteristic pattern of delayed dentition. Cerebral MRI shows hypomyelinated white matter and cerebellar atrophy; 1H-MRS of white matter reveals a marked elevation of myo-inositol.
Subject(s)
Anodontia/complications , Ataxia/complications , Atrophy/complications , Brain/pathology , Cerebellum/pathology , Nervous System Malformations/complications , Age of Onset , Anodontia/pathology , Ataxia/pathology , Ataxia/physiopathology , Atrophy/pathology , Atrophy/physiopathology , Basal Ganglia/metabolism , Basal Ganglia/pathology , Basal Ganglia/physiopathology , Body Height/genetics , Brain/metabolism , Brain/physiopathology , Cerebellum/metabolism , Cerebellum/physiopathology , Child , Child, Preschool , Choline/metabolism , Disease Progression , Female , Humans , Inositol/metabolism , Magnetic Resonance Imaging , Magnetic Resonance Spectroscopy , Myelin Sheath/metabolism , Myelin Sheath/pathology , Nerve Fibers, Myelinated/pathology , Nervous System Malformations/pathology , Nervous System Malformations/physiopathology , Syndrome , Telencephalon/metabolism , Telencephalon/pathology , Telencephalon/physiopathologyABSTRACT
Ischemia and hypoxia are frequent potential sources of secondary brain damage after a variety of brain injuries. Cerebral oxygen extraction may be altered by coma as well as therapeutic interventions. In consequence, monitoring of cerebral O2 availability and utilization has become an important challenge for clinicians. However, measurement of cerebral oxygen extraction in children currently is not included into routine clinical care. This paper describes the measurement of O2-saturation in the jugular bulb in four comatose infants and children (in one continuously) following cardiac arrest or head injury. Our data demonstrate that this procedure served as a valuable tool in the management of those patients. Arterio-jugular oxygen content and lactate differences were used for the establishment and adjustment of therapeutic procedures and moreover, provided relevant information for the interpretation of other cerebral surveillance parameters.
