ABSTRACT
A comparison of clinical skin-tesing using the prick-test and the intracutaneous test with the radio-allergo-sorbent-test (RAST) in 167 patients with different immediate-type allergies showed concordant results in 75.7 per cent of the cases. In 20 per cent of the cases, the skin-test was positive while the simultaneous RAST was negative. Results in male and female patients did not show any important difference. The two test methods agreed well with selected antigens, e.g. grass-pollen, animal-epithelium, fungi and egg white; whereas, the two methods showed considerably different results using tree pollen and housedust as antigens.
Subject(s)
Allergens , Hypersensitivity/diagnosis , Radioimmunoassay , Skin Tests , Female , Food Hypersensitivity/diagnosis , Humans , Male , Respiratory Hypersensitivity/diagnosisABSTRACT
After oral consumption of 150 000 U vitamin A-palmitate the serum of eight healthy men was hourly determined for vitamin A-concentration. Rapidly ascending to a maximum within three to four hours the concentration returned exponentially to its normal fasting level after 24 hours. The curve could be adapted to the BATEMAN-function. The velocity constants k1 and k2 were equal except for one case. These results were opposite to earlier results of patients with psoriasis vulgaris.
Subject(s)
Vitamin A/blood , Adult , Humans , Male , Palmitates/administration & dosage , Stimulation, Chemical , Time Factors , Vitamin A/administration & dosageABSTRACT
After oral application of vitamin-A-palmitate in male patients with psoriasis we hourly estimated the serum concentration of vitamin A. With rapidly elevating the maximum vitamin A level was achieved in 3-4 hrs but redescended to the initial level within 24 hrs by an exponential decrease. The curve could be fitted to the "BATEMANfunction". The velocity contents k1 and k2 were calculated but were varied individually. The constant b, the time between oral application and the commencement of resorption, was estimated at 30-60 min. The chromatographical analysis of the total vitamin A in all patients yielded a unique ratio of vitamin A-alcohol, -acetate and -palmitate for each hour.
