Comparison of the Manchester-Oxford Foot Questionnaire (MOXFQ) and the Self-Reported Foot and Ankle Outcome Score (SEFAS) in patients with foot or ankle surgery.

BACKGROUND: Patient-reported outcome measures are a critical tool in evaluating the efficacy of orthopedic procedures. The intention of this study was to compare the psychometric properties of the Manchester-Oxford Foot Questionnaire (MOXFQ) and the Self-Reported Foot and Ankle Outcome Score (SEFAS) in patients with foot or ankle surgery. METHODS: 177 patients completed both scores and FAOS, Foot and Ankle Outcome Score (FAOS), Short Form 36 (SF-36) and numeric scales for pain and disability (NRS) before and after surgery. Test-Retest reliability, internal consistency, floor and ceiling effects, construct validity, responsiveness and minimal important change were analyzed. RESULTS: The MOXFQ and SEFAS demonstrated excellent test-retest reliability with interclass correlation coefficient values >0.9 Cronbach's alpha (α) values demonstrated strong internal consistency. No floor or ceiling effects were observed for both questionnaires. As hypothesized MOXFQ subscales correlated strongly with corresponding SEFAS, FAOS and SF-36 domains. MOXFQ subscales showed excellent responsiveness between preoperative assessment and postoperative follow-up, whereas SEFAS demonstrated moderate responsiveness. CONCLUSIONS: The MOXFQ and SEFAS demonstrated good psychometric properties and proofed to be valid and reliable instruments for use in foot and ankle patients. MOXFQ showed better outcomes in responsiveness.

Short stem survival after osteonecrosis of the femoral head.

INTRODUCTION: Short stems were developed as a bone-conserving alternative especially for the young hip arthroplasty patient. Patients suffering from osteonecrosis of the femoral head are frequently younger than primary arthritis patients. The outcome of short stems in these patients remains unclear. The aim of our study was to compare mid-term survival of short stems after osteonecrosis of the femoral head (ONFH) and primary arthritis. MATERIALS AND METHODS: Data on short stem implantations over a 10-year period were collected. Demographic data and X-ray measurements before and after surgery were recorded. Indication for operation was determined from medical records and X-rays. Patients were asked by post about any revision. Reason for revision was identified by analysis of operation protocols. Short stem revision rates were analyzed using Kaplan-Meier charts, comparing 212 ONFH patients (231 operations) and 1284 primary arthritis patients (1455 operations). RESULTS: Follow-up time averaged 5.3 and 6 years and was complete for 92% (ONFH) and 94% (primary arthritis) of the patients. ONFH patients were significantly younger (53 years vs. 59 years, p < 0.001) and more frequently male (55 vs. 42%, p < 0.001). The total revision rate did not differ between the two groups (8 years: 4.2 vs. 5.6%, p = ns). A trend towards more stem revisions was detected for ONFH patients (3 vs. 1.8%, p = ns). The aseptic stem loosening rate was significantly elevated for osteonecrosis patients (8 years: 2.6 vs. 0.7%, p = 0.013). CONCLUSIONS: Our study showed elevated short stem loosening rates after ONFH. Similar results are published for classic cementless stems. The question of which stem is best for the young osteonecrosis patient cannot be answered yet. Consecutive studies directly comparing loosening rates of short and classic cementless stems in young osteonecrosis patients are required.

[Treatment of Hallux Valgus: Current Diagnostic Testing and Surgical Treatment Performed by German Foot and Ankle Surgeons]. / Aktuelle diagnostische und therapeutische Vorgehensweise bei Hallux-valgus-Deformität ­ Ergebnisse einer bundesweiten Umfrage und Vergleich mit der internationalen Literatur.

BACKGROUND: Hallux valgus is one of the most prevalent foot deformities, and surgical treatment of Hallux valgus is one of the most common procedures in foot and ankle surgery. Diagnostic and treatment standards show large variation despite medical guidelines and national foot and ankle societies. The aim of this nationwide survey is a description of the current status of diagnostics and therapy of Hallux valgus in Germany. MATERIAL AND METHODS: A nationwide online questionnaire survey was sent to two German foot and ankle societies. The participants were asked to answer a questionnaire of 53 questions with four subgroups (general, diagnostics, operation, preoperative management). Surgical treatment for three clinical cases demonstrating a mild, moderate and severe Hallux valgus deformity was inquired. RESULTS: 427 foot and ankle surgeons answered the questionnaire. 388 participants were certified foot and ankle surgeons from one or both foot and ankle societies. Medical history (78%), preoperative radiographs (100%) and preoperative radiographic management (78%) are of high or very high importance for surgical decision pathway. Outcome scores are used by less than 20% regularly. Open surgery is still the gold standard, whereas minimally invasive surgery is performed by only 7%. CONCLUSION: Our survey showed that diagnostic standards are met regularly. There is a wide variation in the type of procedures used to treat Hallux valgus deformity. TMT I arthrodesis is preferred in severe Hallux valgus, but also used to treat moderate and mild deformities. Minimally invasive surgery is still used by a minority of surgeons. It remains to be seen, to what extent minimally invasive surgery will be performed in the future.

No benefit of autologous transfusion drains in total knee arthroplasty.

PURPOSE AND HYPOTHESIS: Autologous blood transfusion drains are commonly used to reduce allogeneic blood transfusion rate after total knee arthroplasty. There is conflicting evidence as to whether autologous transfusion drains (ABT drains) were effective when restrictive transfusion triggers were used. The aim of our study was to ascertain where, as a part of a blood management protocol, autologous blood transfusion drains reduce the allogeneic blood transfusion rate after total knee arthroplasty. METHODS: Two-hundred total knee arthroplasty patients were included in the prospective randomized controlled study. After implantation, a Redon drain without vacuum assistance (control, n = 100) or an autologous blood transfusion drain (ABT group, n = 100) was used. Demographic and operative data were collected. The blood loss, total blood loss, blood values and transfusion rate were documented. RESULTS: The blood loss in the drains was significantly increased for the ABT group (409 vs. 297 ml, p < 0.001). There was a non-significant trend towards a higher total blood loss for ABT patients (1844 vs. 1685 ml, n.s.). The allogeneic blood transfusion rate was similar for both groups (8 vs. 9%, n.s.). Similarly, the number of transfused blood units was comparable between both groups (0.2U/patient vs. 0.17U/patient n.s.). CONCLUSION: In combination with restrictive blood transfusion triggers, ABT drains had no positive effect on the allogeneic blood transfusion rate. The blood loss in ABT drains was higher. As a consequence, the use of ABT drains was discontinued. LEVEL OF EVIDENCE: I.

Reliability, validity and responsiveness of the German self-reported foot and ankle score (SEFAS) in patients with foot or ankle surgery.

BACKGROUND: Patient-reported outcome measures are a critical tool in evaluating the efficacy of orthopedic procedures and are increasingly used in clinical trials to assess outcomes of health care. The intention of this study was to develop and culturally adapt a German version of the Self-reported Foot and Ankle Score (SEFAS) and to evaluate reliability, validity and responsiveness. METHODS: According to Cross Cultural Adaptation of Self-Reported Measure guidelines forward and backward translation has been performed. The German SEFAS was investigated in 177 consecutive patients. 177 Patients completed the German SEFAS, Foot and Ankle Outcome Score (FAOS), Short-Form 36 and numeric scales for pain and disability (NRS) before and 118 patients 6 months after foot or ankle surgery. Test-Retest reliability, internal consistency, floor and ceiling effects, construct validity and minimal important change were analyzed. RESULTS: The German SEFAS demonstrated excellent test-retest reliability with ICC values of 0.97. Cronbach's alpha (α) value of 0.89 demonstrated strong internal consistency. No floor or ceiling effects were observed for the German version of the SEFAS. As hypothesized SEFAS correlated strongly with FAOS and SF-36 domains. It showed moderate (ES/SRM > 0.5) responsiveness between preoperative assessment and postoperative follow-up. CONCLUSION: The German version of the SEFAS demonstrated good psychometric properties. It proofed to be a valid and reliable instrument for use in foot and ankle patients. TRIAL REGISTRATION: DRKS00007585.

Assessment of reliability, validity, responsiveness and minimally important change of the German Hip dysfunction and osteoarthritis outcome score (HOOS) in patients with osteoarthritis of the hip.

Patient-reported outcome measures are a critical tool in evaluating the efficacy of orthopedic procedures. The intention of this study was to evaluate reliability, validity, responsiveness and minimally important change of the German version of the Hip dysfunction and osteoarthritis outcome score (HOOS). The German HOOS was investigated in 251 consecutive patients before and 6 months after total hip arthroplasty. All patients completed HOOS, Oxford-Hip Score, Short-Form (SF-36) and numeric scales for pain and disability. Test-retest reliability, internal consistency, floor and ceiling effects, construct validity and minimal important change were analyzed. The German HOOS demonstrated excellent test-retest reliability with intraclass correlation coefficient values > 0.7. Cronbach´s alpha values demonstrated strong internal consistency. As hypothesized, HOOS subscales strongly correlated with corresponding OHS and SF-36 domains. All subscales showed excellent (effect size/standardized response means > 0.8) responsiveness between preoperative assessment and postoperative follow-up. The HOOS and all subdomains showed higher changes than the minimal detectable change which indicates true changes. The German version of the HOOS demonstrated good psychometric properties. It proved to be valid, reliable and responsive to the changes instrument for use in patients with hip osteoarthritis undergoing total hip replacement.

Low Short-Stem Revision Rates: 1-11 Year Results From 1888 Total Hip Arthroplasties.

BACKGROUND: In total hip arthroplasty, short stems were developed as a bone-conserving alternative to traditional cementless stems. So far, there have been very few recorded medium to long-term results of these comparatively new implants. The aim of our retrospective study was to report on the survival of calcar-loading short stems. METHODS: All Metha stem implantations from 2004 to 2014 were recorded from the operation protocols (n = 1888). Due to the chronological development of the stem, 3 different versions were implanted: modular titanium stems with neck adapters from titanium or cobalt-chrome and monoblock stems. Patients were questioned by post about revision, dislocation, and satisfaction. RESULTS: Data were complete for 93% of the procedures (1090 monoblock stems, 314 modular stems with titanium neck, and 230 modular stems with cobalt chrome neck). Mean follow-up was 6 years (1-11 years). Fifteen modular titanium implants were affected by cone fractures (4%). Therefore, monoblock, modular cobalt chrome, and modular titanium implants were analyzed separately. The 7-year revision rate for monoblock stems was 1.5%; for modular cobalt-chrome stems it was 1.8%, and for modular titanium stems it was 5.3%. CONCLUSION: Our data show the midterm survival of the monoblock and modular cobalt-chrome implants equivalent to the traditional cementless stems. These might, therefore, be considered as a bone-conserving alternative for young and active patients.

Pre-operative arthritis severity as a predictor for total knee arthroplasty patients' satisfaction.

PURPOSE: Studies have shown that up to 25% of TKA patients are dissatisfied with the implanted knee, even if registry data shows ten-year revision rates below 5%. It has been the question of our study, if it would be possible to identify those patients at risk for dissatisfaction pre-operatively. METHODS: The data of 1,121 consecutive TKA patients with a follow-up between one and six years have been analysed retrospectively. Demographic, radiologic and perioperative variables have been recorded and all patients were asked by questionnaire for satisfaction with the implanted knee. Logistic regression models have been used to identify significant risk factors. RESULTS: The data of 996 patients (89%) were complete, 849 (85.2%) reported satisfaction and 147 (14.8%) dissatisfaction. Patients' satisfaction was independent of the time after operation (p = 0.285). The only factor which influenced patients' satisfaction was the osteoarthritic severity. In comparison to severe arthritis Kellgren Lawrence IV°, the risk for dissatisfaction was 2.556-fold elevated for arthritis grade III° (p < 0.001) and 2.956-fold higher for grade II° (p = 0.001). CONCLUSIONS: Patients suffering from mild or moderate osteoarthritis are at risk for dissatisfaction after TKA. The TKA indication in those patients should therefore be critically proven. Furthermore, to adjust patients' expectations, the elevated dissatisfaction risk in case of mild or moderate osteoarthritis should be included into patients' pre-operative information.

Influence of computer navigation on TKA revision rates.

PURPOSE: We performed this study to determine whether the use of imageless navigation reduces revision rates after total knee arthroplasty (TKA). METHODS: Data of 1,121 consecutive primary TKA with a follow-up of one to six years were retrospectively analysed. Following the conversion of the standard technique from conventional to navigated procedures, these data included the last 342 conventional and first 779 navigated procedures performed in our clinic. Demographic and perioperative covariates were recorded. All patients were asked by post to report instances of revisions. RESULTS: Data of 1,054 patients (94 %) were complete. Mean follow-up was 3.9 years for conventional and 2.4 years for navigated operations. Cumulative revision rate averaged 4.7 % for conventional and 2.3 % for navigated procedures. Cox's proportional hazard model was used to assess the effect of covariates on survival, resulting in significantly lower revision rates for older patients (p < 0.001) and for the navigated technique (p = 0.012). The reduced revision rate for navigated operations was mainly caused by a significantly reduced rate of aseptic implant loosening (1.9 % vs. 0.1 %, p = 0.024). CONCLUSIONS: Our study showed lower revision rates when computer navigation was used. However, due to the retrospective uncontrolled design, further prospective trials will be necessary to further evaluate this effect.

Is the effect of a posterior cruciate ligament resection in total knee arthroplasty predictable?

PURPOSE: It is broadly supposed that in total knee arthroplasty, the flexion/extension gap ratio is increased after resection of the posterior cruciate ligament (PCL). However, studies are rare and results are inconsistent. Therefore, this study was conducted to determine whether PCL release regularly increases the flexion gap. METHODS: Data from 50 consecutive posterior stabilised knee prostheses were analysed retrospectively. Using imageless computer navigation, the joint-gap width was measured over the entire range of motion before and after PCL release. RESULTS: PCL release had no effect on the extension gap, but it increased the flexion gap significantly. An increase of >3 mm occurred in 36% of patients and of >5 mm in 12%. No clinically relevant effect (<2 mm) was found in 44% of patients. CONCLUSION: PCL release increased the flexion/extension gap ratio on average, but the individual effect could not be predicted. Therefore, we recommend PCL release before the femoral resections are performed, as this step mainly determines the ratio between extension and flexion gap.

Displays mounted on cutting blocks reduce the learning curve in navigated total knee arthroplasty.

The use of computer navigation in total knee arthroplasty (TKA) improves the implant alignment but increases the operation time. Studies have shown that the operation time is further prolonged due to the surgeon's learning curve, and longer operation times have been associated with higher morbidity risks. It has been our hypothesis that an improvement in the human-machine interface might reduce the time required during the learning curve. Accordingly, we asked whether the use of navigation devices with a display fixed on the surgical instruments would reduce the operation time in navigated TKAs performed by navigation beginners. Thirty medical students were randomized and used two navigation devices in rotation: these were the Kolibri® device with an external display and the Dash® device with a display that was fixed on the cutting blocks. The time for adjustment of the tibial and femoral cutting blocks on knee models while using these devices was measured. A significant time reduction was demonstration when the Dash® device was used: The time reduction was 21% for the tibial block (p = 0.007), 40% for the femoral block (p < 0.001), and 32% for the whole procedure (p < 0.001). The integrated display, fixed on surgical instruments in a manner similar to a spirit level, seems to be more user-friendly for navigation beginners. Hence, unproductive time losses during the learning curve may be diminished.

Do residents perform TKAs using computer navigation as accurately as consultants?

The implantation of a total knee arthroplasty (TKA) is a milestone in a resident's surgical training. Studies demonstrate higher loosening rates after TKA by inexperienced surgeons. Alignment outliers should be avoided to achieve a long implant survival. Therefore, our study questioned whether residents implant knee prostheses using computer navigation as accurately as experienced consultants. The data for 662 consecutive TKAs were analyzed retrospectively. The operations were performed by 4 consultants (n=555) and 5 residents under supervision by a consultant (n=107). Cutting errors were recorded from the navigation data. The postoperative mechanical axis and operation time were recorded. Operation time was significantly prolonged if residents performed the operation vs consultants (139 vs 122 minutes, respectively). The analysis of cutting errors within each surgeon's first 20 navigated operations resulted in no significant difference between residents and consultants. During the subsequent operations, a trend toward a more accurate placement of the prosthesis was detected for consultants. The rate of outliers with a mechanical axis deviation >2° was low and did not significantly differ between residents and consultants (3.7% vs 2.3%, respectively). Our study shows that residents implant their first TKA using computer navigation as accurately as experienced consultants. However, the residents' operations take longer and therefore incur additional costs for the teaching clinic.

How much tibial resection is required in total knee arthroplasty?

The purpose of our study was to calculate the optimal tibial resection depth in total knee arthroplasty. The data from 464 navigated total knee arthroplasties were analysed. An implant with a minimum insert thickness of 8 mm was used. Data regarding leg axis, joint line, insert thickness and tibial resection depth were recorded by the navigation device. An algorithm was developed to calculate the optimal tibial resection depth. The required tibial resection significantly correlates with the preoperative leg axis (p < 0.001). In valgus deformities the required resection depth averaged 5.1 mm and was significantly reduced compared to knees with a neutral leg axis (6.8 mm, p < 0.001) and varus deformities (8.0 mm, p < 0.001). Manufacturers recommend undercutting the high side of the tibial plateau to the depth of the thinnest insert available. However, our study demonstrates that in valgus deformities a reduced tibial resection depth is preferable. Hence, unnecessary bone loss can be avoided.

[Imageless computer navigation of hip resurfacing arthroplasty]. / Bildfreie Computernavigation von Hüftoberflächenersatzprothesen.

OBJECTIVE: Precise implantation of hip resurfacing arthroplasty by imageless computer navigation. Hence a malalignment of the femoral component, leading to early loss of the implant, can safely be avoided. INDICATIONS: Coxarthrosis in patients with normal bone mineral density; only minor deformity of the femoral head that enables milling around the femoral neck without notching. CONTRAINDICATIONS: Osteoporosis; large necrosis of the femoral head; metal allergy; small acetabular seat and corresponding wide femoral neck, leading to needless acetabular bone loss; pregnancy, lactation. SURGICAL TECHNIQUE: Hip joint exposure by a standard surgical approach, bicortical placement of a Schanz screw for the navigation array in the lesser trochanter. Referencing of the epicondyles, the four planes around the femoral neck and head by use of the navigation pointer. Planning of the desired implant position on the touchscreen of the navigation device; a guide wire is inserted into the femoral head and neck using the navigated drill guide; navigated depth drilling is performed. The femoral head is milled using the standard instruments. The acetabular bone stock is prepared with the conventional instrumentation; high-viscosity cement is finger-packed on the reamed head and the femoral component is inserted. Hammer blows should be avoided to prevent microfractures. Verification of the implant position by the navigation device; displacement of the Schanz screw; joint reposition and closure of the wound. POSTOPERATIVE MANAGEMENT: Standard postoperative management after hip arthroplasty. RESULTS: The comparison of 40 navigated and 32 conventionally implanted ASR prostheses resulted in a significant reduction of outliers by use of computer navigation (navigated procedures: one outlier, conventional procedure: nine outliers; p<0.001). Accuracy of the navigation device was tested by analysis of planned and verified implant position: CCD angle accuracy was 1 degrees , antetorsion accuracy was 1 degrees , and offset accuracy was 1.5 mm. An ongoing computed tomography-based anatomic study proved a varus-valgus accuracy of the navigation device of 1 degrees .

The effect of computer navigation on blood loss and transfusion rate in TKA.

The blood loss that accompanies total knee arthroplasty (TKA) can be substantial. Many patients need perioperative blood transfusions. To avoid anemia and transfusion-related complications, the amount of blood loss and need for blood transfusions must be reduced. If standard jig instruments are used, an opening of the femoral medullary canal is required. This operative step has been recognized as a reason for elevated blood loss; it is not required if computer navigation is used. Hence, the purpose of this study was to investigate the effect of computer navigation on blood loss and transfusion rate in TKA. The data of 500 consecutive patients undergoing TKA were analyzed, and patient- and operation-related data and blood loss and transfusion rates were recorded. The total blood loss was calculated by use of the Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) formula. The average blood loss in the drainages (standard procedures, 880 mL; navigated procedures, 761 mL; P=.001) and the calculated total blood loss (standard procedures, 1375 mL; navigated procedures, 1242 mL; P=.036) were significantly reduced in the navigation group. The transfusion rate of navigated procedures was almost halved (standard procedures, 0.23 transfusions/patient; navigated procedures, 0.12 transfusions/patient; P=.035). Our study demonstrated a reduced blood loss if TKAs were implanted by use of computer navigation. The diminished blood loss resulted in a 50% reduction of allogenic blood transfusions. Hence, computer navigation may be attractive for patients with a high risk of transfusions or uncommon blood groups. Prospective studies are required to verify this potential benefit of computer navigation.

Is referencing the posterior condyles sufficient to achieve a rectangular flexion gap in total knee arthroplasty?

Femoral malrotation in total knee arthroplasty causes flexion gap instability. Conventional instruments mostly reference the posterior condylar angle (PCA). The aim of this study was to verify whether the computer-navigated flexion gap (GAP) method produces a rectangular flexion gap and if a balanced flexion gap could also be achieved by referencing the PCA. A total of 100 knee prostheses were analysed using the navigated GAP method, and flexion gap symmetry along with femoral rotation were recorded. The GAP technique resulted in a rectangular flexion gap with adequate femoral rotational alignment. If the PCA technique had been used, only 51% of the femoral components would have been implanted in correct femoral rotation; the remaining 49% would have implanted with flexion gap instability. The GAP technique produces a rectangular flexion gap. The referencing of the PCA was shown to be less reliable. Thus, modern knee prosthesis instrumentation should not base femoral rotation solely on the PCA.

Treatment delay of bone tumours, compilation of a sociodemographic risk profile: a retrospective study.

BACKGROUND: Bone tumours are comparatively rare tumours and delays in diagnosis and treatment are common. The purpose of this study was to analyse sociodemographic risk factors for bone tumour patients in order to identify those at risk of prolonged patients delay (time span from first symptoms to consultation), professional delay (from consultation to treatment) or symptom interval (from first symptoms to treatment). Understanding these relationships might enable us to shorten time to diagnosis and therapy. METHODS: We carried out a retrospective analysis of 265 patients with bone tumours documenting sociodemographic factors, patient delay, professional delay and symptom interval. A multivariate explorative Cox model was performed for each delay. RESULTS: Female gender was associated with a prolonged patient delay. Age under 30 years and rural living predisposes to a prolonged professional delay and symptom interval. CONCLUSION: Early diagnosis and prompt treatment are required for successful management of most bone tumour patients. We succeeded in identifying the histology independent risk factors of age under 30 years and rural habitation for treatment delay in bone tumour patients. Knowing about the existence of these risk groups age under 30 years and female gender could help the physician to diagnose bone tumours earlier. The causes for the treatment delays of patients living in a rural area have to be investigated further. If the delay initiates in the lower education of rural general physicians, further training about bone tumours might advance early detection. Hence the outcome of patients with bone tumours could be improved.

Endogenous endotoxin participates in causing a panenteric inflammatory ileus after colonic surgery.

OBJECTIVE: To investigate muscularis inflammation and endogenous endotoxin as causes of postoperative ileus. BACKGROUND: Postoperative inflammatory ileus of the colon is associated with a significant delay in gastrointestinal transit. We investigated whether these changes are caused by the downstream obstructive barrier of the surgically altered colon or by small intestinal muscularis inflammation itself. Furthermore, we evaluated the mechanistic role of gut derived endotoxin in the development of postoperative intestinal dysfunction. METHODS: Rats underwent surgical manipulation of the colon. Isolated gastrointestinal transit was analyzed in animals with ileostomy. The perioperative emigration of intracolonic particles was investigated by colonic luminal injection of fluorescently labeled LPS and microspheres. Mediator mRNA induction was quantified by real-time RT-PCR. Muscularis leukocytic infiltrates were characterized. In vitro circular muscle contractility was assessed in a standard organ bath. RESULTS: Ileostomy rats presented with a significant delay in small intestinal transit after colonic manipulation. This was associated with leukocyte recruitment and inflammatory mediator mRNA induction within the small intestinal muscularis. Colonic manipulation caused the transference of intracolonic LPS and microspheres into the intestinal muscularis. Postoperative in vitro small intestinal circular muscle contractility was impaired by 42% compared with controls. Gut decontamination and TLR-4 deletion significantly alleviated the small intestinal muscularis inflammation and prevented intestinal muscle dysfunction. CONCLUSIONS: Selective colonic manipulation initiates a distant inflammatory response in the small intestinal muscularis that contributes to postoperative ileus. The data provide evidence that gut-derived bacterial products are mechanistically involved in the initiation of this remote inflammatory cascade.