ABSTRACT
A cohort of 1,804 residents of Rochester, Minnesota, who were at least 50 years old, free of stroke, and who underwent examination at the Mayo Clinic in 1960, was followed for 13 years. During this period, there were 110 first ischemic strokes and 616 deaths without stroke. The time of onset, if available, or the time of diagnosis of potential risk factors was determined for all patients during the study and was used to construct a proportional hazards model of time to occurrence of stroke with time-dependent risk factors. The model included 8 risk factors (2 fixed and 6 time-dependent). For these, the individual relative risks are: 1.6 for age (per 10 years), 2.0 for males, 4.0 for definite hypertension, 3.9 for transient ischemic attacks, 2.2 for hypertensive heart disease, 2.2 for coronary heart disease, 1.7 for congestive heart failure, and 1.7 for diabetes mellitus. Atrial fibrillation was not a significant risk factor using time-dependent multivariate analysis.
Subject(s)
Brain Ischemia/complications , Cerebrovascular Disorders/etiology , Cerebrovascular Disorders/mortality , Female , Humans , Male , Middle Aged , Models, Neurological , Models, Theoretical , Prospective Studies , Risk FactorsABSTRACT
A door-to-door survey was conducted in six cities of the People's Republic of China. A total of 63,195 individuals were sampled during 1983 to determine the prevalence of major neurologic disorders. The survey involved a complete census, followed by a pretested interview and brief screening examination with a high level of sensitivity for detecting individuals with frequently occurring neurologic diseases, including movement disorders. Subjects with abnormal responses or findings were examined by a neurologist. There was 100% cooperation among the study subjects. Twenty-eight individuals alive on prevalence day (Jan 1, 1983) were identified as having Parkinson's disease, yielding an age-adjusted (to the 1960 US population) prevalence ratio of 57 per 100,000 population. All subjects were older than the age of 50 years. After the fifth decade of life, the age-specific prevalence ratios increased with age.
Subject(s)
Movement Disorders/epidemiology , Parkinson Disease/epidemiology , Aged , China , Female , Health Surveys , Humans , Male , Middle AgedSubject(s)
Eponyms , Lipoma/history , General Surgery/history , History, 18th Century , History, 19th Century , Humans , LondonSubject(s)
Eponyms , Austria , California , History, 19th Century , History, 20th Century , New York City , Thromboangiitis Obliterans/historySubject(s)
Eponyms , Pancoast Syndrome/history , History, 20th Century , Humans , Radiology/history , United StatesSubject(s)
Eponyms , Neurology/history , Staining and Labeling/history , Brain/anatomy & histology , Germany , History, 19th Century , History, 20th Century , Humans , Italy , SpainSubject(s)
Eponyms , Medical Illustration/history , Neurology/history , England , History, 19th Century , Humans , Muscular Dystrophies/history , SyndromeABSTRACT
A 10-year review of the Mayo Clinic experience with childhood cerebrovascular disease unrelated to birth, intracranial infection, or trauma identified 69 patients (38 with ischemic stroke, and 31 with subarachnoid or intracerebral hemorrhage). Although children with cerebral infarction had better survival, they experienced more residual disability than children with cerebral hemorrhage. The medical records-linkage system for Rochester, Minnesota residents made it possible for the first time to study cerebrovascular disease in a well-defined childhood population. Records from all medical facilities serving this population (average of 15,834 resident children) showed four strokes over 10 years (average annual incidence rate of 2.52 cases per 100,000 per year).
Subject(s)
Cerebrovascular Disorders , Age Factors , Cerebral Hemorrhage/complications , Cerebrovascular Disorders/epidemiology , Cerebrovascular Disorders/mortality , Child , Hemiplegia/etiology , Humans , Infant , Intracranial Arteriovenous Malformations/complications , Moyamoya Disease/complicationsSubject(s)
Refsum Disease/history , Adult , Female , History of Medicine , Humans , Male , Neurology/history , Norway , United StatesABSTRACT
A review of the recent Mayo Clinic experience with stroke in children having cerebral angiography revealed five patients with moyamoya disease. The disease commonly presents as recurrent strokes and only rarely as a seizure disorder. The angiographic pattern suggests that the telangiectasia characteristic of this condition represents normally present dilated vessels.
