Subject(s)
Antineoplastic Agents/adverse effects , Hand/pathology , Hydroxyurea/adverse effects , Hyperpigmentation/chemically induced , Myeloproliferative Disorders/drug therapy , Nail Diseases/diagnosis , Aged, 80 and over , Diagnosis, Differential , Female , Humans , Hyperpigmentation/diagnosis , Hyperpigmentation/pathology , Hypertension , Hypothyroidism , Nail Diseases/chemically induced , Nail Diseases/pathology , Pulmonary Disease, Chronic Obstructive , StrokeABSTRACT
This report details an acral melanoma in-situ on theright plantar foot that was successfully treated withMohs micrographic surgery and secondary intentionwound healing.
Subject(s)
Foot , Melanoma/surgery , Skin Neoplasms/surgery , Wound Healing , Aged , Female , Humans , Melanoma/pathology , Mohs Surgery , Neoplasm Staging , Skin Neoplasms/pathologyABSTRACT
Methylisothiazolinone (MI) is commonly used as a preservative in personal care products and is a frequent cause of allergic contact dermatitis. We present a patient with allergic contact dermatitis caused by MI in hair care products and discuss this allergen to bring attention to this common cause of contact dermatitis, and to highlight its frequent use in hair care products. If allergy to MI is suspected, testing should be performed to this individual preservative, as testing solely for the combination preservative, methylisothiazolinone/methylchloroisothiazolinone (Kathon CG®), may miss many cases of MI allergy.
Subject(s)
Mycosis Fungoides/diagnosis , Neoplasms, Multiple Primary/diagnosis , Skin Neoplasms/diagnosis , Tongue Neoplasms/diagnosis , Aged, 80 and over , Humans , Male , Mycosis Fungoides/pathology , Neoplasms, Multiple Primary/pathology , Skin Neoplasms/pathology , Tongue Neoplasms/pathologyABSTRACT
There is uncertainty regarding the pathogenic nature of cytomegalovirus in cutaneous lesions co-infected with herpes simplex virus. It is widely believed that herpes simplex virus is the main pathogenic factor in such lesions and that cytomegalovirus plays little if any role. There are, however, isolated case reports that describe cytomegalovirus as an important driving pathogen in such lesions. The authors present two human immunodeficiency virus patients who have cytomegalovirus and herpes simplex virus co-infected perigenital ulcers, one of whom improved on valacyclovir, while the other, who was already on valacyclovir for chronic herpes simplex virus suppression, showed no improvement with a single dose of cidofovir. He only showed rapid improvement when treated with valganciclovir. The latter patient underscores the viewpoint that at least in some cases, cytomegalovirus may be an important driving force behind the formation of such lesions. The authors therefore recommend that clinicians be aware of the possible pathogenic role of cytomegalovirus in these ulcers, and, in nonhealing ulcers, use anti-cytomegalovirus agents to prevent the onset of systemic disease. These results warrant further study of the pathogenesis of cytomegalovirus in co-infected herpes simplex virus ulcers.
