Subject(s)
Molar, Third/surgery , Molar , Periodontium/anatomy & histology , Surgical Flaps , Tooth Extraction , Adolescent , Adult , Alveolar Process/anatomy & histology , Female , Humans , Male , MethodsABSTRACT
This study was undertaken to examine the effectiveness of a commercially available n-butyl-2-cyanoacrylate (Histoacryl blue+) as a local treatment for cutaneous ulcers. Two ulcers, approximately 0.5 cm2 each, were made on the backs of 30 hamsters. The right side was covered with a thin film of tissue adhesive, while the left side was left untreated as a control. Animals were sacrificed at various times post-operatively, the tissue excised, processed, and examined with the light microscope. Results showed that cyanoacrylate decreased the inflammatory exudate early in the experiment, and epithelial migration occurred slightly earlier in experimental tissue. Scab formation was absent in experimental sites until the layer of adhesive was lost. After 2 days, healing was comparable in both experimental and control, and the sites were indistinguishable histologically at day 5.
Subject(s)
Enbucrilate/analogs & derivatives , Skin Ulcer/drug therapy , Animals , Cricetinae , Enbucrilate/therapeutic use , Epithelium/drug effects , Skin/pathology , Skin Ulcer/pathology , Staining and Labeling , Time FactorsABSTRACT
Previous histological studies of cyanoacrylate in wound healing have all used Oil-Red-O staining of paraffin sections prepared by routine method. In the course of our studies we began to suspect that artifact was being introduced because of dissolution of cyanoacrylate during processing. Accordingly, biopsis of wounds sealed with cyanoacrylate and pieces of cyanoacrylate of a standard known dimension with no associated tissue were observed after every stage of histological preparation. It was observed that approximately 80% of the cyanoacrylate was lost at the deparaffinization in xylene stage. Accordingly, a number of solvents were tested, and it was found that petroleum ether could be used to remove paraffin completely without the loss of any of the cyanoacrylate from the specimen. This technique has been used to view the location and ultimate fate of cyanoacrylate applied to wounds and examined at different stages in healing process. It is concluded that previous histological studies of cyanoacrylate in wound healing have been inaccurate due to leaching out of most of the tissue adhesive during deparaffinization of the specimen.
Subject(s)
Cyanoacrylates/analysis , Tissue Adhesives/analysis , Animals , Cricetinae , Histocytochemistry , Solubility , Staining and Labeling , Time Factors , Wound Healing , Wounds and Injuries/pathologyABSTRACT
The two cases presented here involved complex composite odontomas that had become cystic. They were very different in appearance; the first case being almost classic and the second case showing more bizarre configuration and being associated with a much larger cystic cavity. Two different surgical approaches were used. In the first case a bone graft from the iliac crest was used to fill the extensive mandibular defect. In the second case, enucleation with good primary closure was thought to be sufficient since good bony margins were evident and the likelihood of pathologic fracture was considered minimal.
Subject(s)
Mandibular Neoplasms/pathology , Odontogenic Tumors/pathology , Odontoma/pathology , Adolescent , Adult , Female , Humans , Male , Mandibular Neoplasms/surgery , Odontoma/surgerySubject(s)
Dry Socket/etiology , Adolescent , Adult , Aged , Anesthesia, Dental , Child , Debridement , Dry Socket/surgery , Female , Humans , Male , Mandibular Diseases/etiology , Mandibular Diseases/surgery , Middle Aged , Molar/surgery , Syndrome , Tooth Extraction/adverse effects , Tooth, Impacted/surgerySubject(s)
Dental Plaque/prevention & control , Leucomycins/therapeutic use , Administration, Oral , Adolescent , Adult , Clinical Trials as Topic , Dental Plaque/microbiology , Double-Blind Method , Drug Evaluation , Female , Humans , Leucomycins/administration & dosage , Male , Middle Aged , PlacebosABSTRACT
A case of osteoradionecrosis of the maxilla has been presented. It is hoped that this review and discussion of osteomyelitis and osteoradionecrosis will point out the need for proper management of the dentition of cancer patients who are subjected to radiotherapy.
Subject(s)
Maxilla/radiation effects , Osteoradionecrosis/etiology , Radiation Injuries/etiology , Carcinoma, Squamous Cell/radiotherapy , Humans , Male , Maxillary Neoplasms/radiotherapy , Middle Aged , Osteomyelitis/etiologySubject(s)
Granuloma, Giant Cell/pathology , Maxillary Diseases/pathology , Child , Humans , Male , RecurrenceABSTRACT
A case of osteosarcoma which displayed a widened PDL space in a dental radiograph was presented. Other causes for thickening of the PDL were reviewed and differentiated from the features seen in osteosarcoma.
