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2.
Clin Neurophysiol ; 129(5): 1056-1082, 2018 05.
Article in English | MEDLINE | ID: mdl-29483017

ABSTRACT

Electroencephalography (EEG) remains an essential diagnostic tool for people with epilepsy (PWE). The International Federation of Clinical Neurophysiology produces new guidelines as an educational service for clinicians to address gaps in knowledge in clinical neurophysiology. The current guideline was prepared in response to gaps present in epilepsy-related neurophysiological assessment and is not intended to replace sound clinical judgement in the care of PWE. Furthermore, addressing specific pathophysiological conditions of the brain that produce epilepsy is of primary importance though is beyond the scope of this guideline. Instead, our goal is to summarize the scientific evidence for the utility of EEG when diagnosing and monitoring PWE.


Subject(s)
Brain/physiopathology , Epilepsy/diagnosis , Seizures/diagnosis , Adult , Electroencephalography , Epilepsy/physiopathology , Humans , Seizures/physiopathology
3.
Epilepsy Res ; 69(1): 80-6, 2006 Apr.
Article in English | MEDLINE | ID: mdl-16516443

ABSTRACT

OBJECTIVE: To evaluate the sensitivity of a simultaneous whole-head 306-channel magnetoencephalography (MEG)/70-electrode EEG recording to detect interictal epileptiform activity (IED) in a prospective, consecutive cohort of patients with medically refractory epilepsy that were considered candidates for epilepsy surgery. METHODS: Seventy patients were prospectively evaluated by simultaneously recorded MEG/EEG. All patients were surgical candidates or were considered for invasive EEG monitoring and had undergone an extensive presurgical evaluation at a tertiary epilepsy center. MEG and EEG raw traces were analysed individually by two independent reviewers. RESULTS: MEG data could not be evaluated due to excessive magnetic artefacts in three patients (4%). In the remaining 67 patients, the overall sensitivity to detect IED was 72% (48/67 patients) for MEG and 61% for EEG (41/67 patients) analysing the raw data. In 13% (9/67 patients), MEG-only IED were recorded, whereas in 3% (2/67 patients) EEG-only IED were recorded. The combined sensitivity was 75% (50/67 patients). CONCLUSION: Three hundred and six-channel MEG has a similarly high sensitivity to record IED as EEG and appears to be complementary. In one-third of the EEG-negative patients, MEG can be expected to record IED, especially in the case of lateral neocortical epilepsy and/or cortical dysplasia.


Subject(s)
Electroencephalography , Epilepsies, Partial/pathology , Magnetoencephalography , Preoperative Care , Adolescent , Adult , Child , Epilepsies, Partial/physiopathology , Epilepsies, Partial/surgery , Female , Humans , Male , Middle Aged , Prospective Studies , Sensitivity and Specificity
4.
Neurology ; 65(7): 1016-20, 2005 Oct 11.
Article in English | MEDLINE | ID: mdl-16217052

ABSTRACT

OBJECTIVE: To compare sexual function and reproductive hormone levels among men with epilepsy who took various antiepileptic drugs (AEDs), untreated men with epilepsy, and normal controls. METHODS: Subjects were 85 men with localization-related epilepsy (25 on carbamazepine [CBZ], 25 on phenytoin [PHT], 25 on lamotrigine [LTG], and 10 untreated for at least 6 months [no AED]) and 25 controls. Sexual function scores (S-scores), hormone levels (bioactive testosterone, estradiol), hormone ratios (bioactive testosterone/bioactive estradiol), and gonadal efficiency (bioactive testosterone/luteinizing hormone) were compared among the five groups. RESULTS: S-scores, bioactive testosterone levels, bioactive testosterone/bioactive estradiol, and bioactive testosterone/luteinizing hormone were significantly greater in the control and LTG groups than in the CBZ and PHT groups. Sex hormone binding globulin was significantly higher in the CBZ and PHT groups than in all other groups. S-scores were below the control range in 20% of the men with epilepsy, including 32.0% on CBZ, 24% on PHT, 20% on no AEDs, and 4% on LTG (chi2: p = 0.08 for all four groups; chi2: p = 0.02 for the three AED groups). Bioactive testosterone was below the control range in 28.2%, including 48% on CBZ, 28% on PHT, 20% on no AEDs, and 12% on LTG (chi2: p = 0.02). Among men with epilepsy who had low S-scores, 70.6% had bioactive testosterone levels below the control range as compared to 17.6% among men with normal S-scores (chi2: p < 0.0001). Among men with epilepsy who had abnormally low bioactive testosterone, 50.0% had low S-scores; among men with normal bioactive testosterone, 8.2% had low S-scores (chi2: p < 0.0001). Bioactive testosterone decline with age was significantly greater among men with epilepsy than among controls and notably greater in the CBZ and PHT groups than in the LTG and untreated groups. CONCLUSIONS: Sexual function, bioavailable testosterone levels, and gonadal efficiency in men with epilepsy who took lamotrigine were comparable to control and untreated values and significantly greater than with carbamazepine or phenytoin treatment.


Subject(s)
Anticonvulsants/adverse effects , Gonadal Steroid Hormones/blood , Sex Hormone-Binding Globulin/drug effects , Sexual Dysfunction, Physiological/blood , Sexual Dysfunction, Physiological/chemically induced , Adolescent , Adult , Age Factors , Aging/physiology , Carbamazepine/adverse effects , Cross-Sectional Studies , Down-Regulation/drug effects , Down-Regulation/physiology , Epilepsy/complications , Epilepsy/drug therapy , Epilepsy/physiopathology , Estradiol/blood , Humans , Lamotrigine , Luteinizing Hormone/blood , Male , Middle Aged , Phenytoin/adverse effects , Sex Hormone-Binding Globulin/metabolism , Sexual Dysfunction, Physiological/physiopathology , Testosterone/blood , Triazines/adverse effects
5.
Clin Neurophysiol ; 114(11): 2071-80, 2003 Nov.
Article in English | MEDLINE | ID: mdl-14580605

ABSTRACT

OBJECTIVE: To further evaluate the potential of slew-rate limiting amplifiers to record electrophysiological signals in spite of concurrent transcranial magnetic stimulation (TMS), and to explore the effects of single-pulse TMS on electroencephalographic (EEG) correlates of functional brain activity. METHODS: Visual-evoked potentials (VEPs) to checkerboards were recorded in 7 right-handed subjects, while single-pulse TMS was applied to the occipital pole either at visual stimulus onset, during the build-up or at the expected peak of the early VEP component P1 (VIS&TMS). Timing of TMS was individually adjusted based on each subject's VEP-latency. A condition of TMS without concurrent visual stimulation (TMS(alone)) served for subtraction purposes (VIS&TMS minus TMS(alone)) to partial out TMS-related contaminations of the EEG signal. RESULTS: When TMS was applied at visual stimulus onset, VEPs (as calculated by subtraction) perfectly matched control VEPs to visual stimulation alone. TMS at around P1, in contrast, modified the targeted (P1) and the subsequent VEP component (N1), independently of whether TMS was given at build-up or peak. CONCLUSIONS: The retrieval of regular VEPs with concomitant TMS at visual stimulus onset suggests that the employed EEG system and subtraction procedure are suited for combined EEG-TMS studies. The VEP changes following TMS at around P1 provide direct clues on the temporal dynamics of TMS pulse effects on functional activity in the human brain. Our data suggest effects of relatively long duration (approximately 100 ms) when TMS is applied while functional neuronal activity evolves.


Subject(s)
Evoked Potentials, Visual , Occipital Lobe/physiology , Transcranial Magnetic Stimulation , Adult , Brain Mapping , Electric Stimulation , Electroencephalography , Female , Humans , Male , Photic Stimulation
6.
Clin Neurophysiol ; 112(12): 2288-92, 2001 Dec.
Article in English | MEDLINE | ID: mdl-11738201

ABSTRACT

OBJECTIVES: To determine the accuracy with which electrical sources in the human brain can be located using realistically shaped boundary element models of the head and to compare this accuracy with that using spherical head models. METHODS: In a previous study, electroencephalographs (EEGs) produced by sources at known locations in the brains of human subjects were recorded. The sources were created by injecting current into implanted depth electrodes. The locations of the implanted depth and scalp EEG electrodes and head shape were determined from computerized tomography images. The EEGs were used to calculate source locations in spherical head models and localization accuracy was determined by comparing the calculated and actual locations. In this study, these same EEGs are used to determine localization accuracy in realistically shaped head models. RESULTS: An average localization error of 10.5 (SD=5.4) mm was obtained in the realistically shaped models for all 176 sources in 13 subjects. This compares with 10.6 (5.5) mm in the spherical models. The average localization error for 105 sources at superior locations in the brain is 9.1 (4.2) mm. The average error for 71 inferior location sources is 12.4 (6.4) mm. The corresponding values for the spherical models are 9.2 (4.4) and 12.8 (6.2) mm. CONCLUSIONS: The realistically shaped head boundary element models used in this study produced very nearly the same localization accuracy as spherical models.


Subject(s)
Brain/physiology , Electroencephalography/methods , Head/anatomy & histology , Models, Anatomic , Humans
7.
Clin Neurophysiol ; 112(1): 46-51, 2001 Jan.
Article in English | MEDLINE | ID: mdl-11137660

ABSTRACT

OBJECTIVES: The locations of electrical sources in the brain can be calculated using EEG data. However, the accuracy of these calculations is not well known because it is usually not possible to compare calculated source locations with actual locations since little accurate location information is available about most sources in the brain. METHODS: In this study, sources at known locations are created by injecting current into electrodes implanted in the brains of human subjects. The locations of the implanted and scalp EEG electrodes are determined from CTs. The EEG signals produced by these dipolar sources are used to calculate source locations in spherical head models containing brain, skull, and scalp layers. The brain and scalp layers have the same electrical conductivity while 3 different skull conductivity ratios of 1/80th, 1/40th, and 1/20th of brain and scalp conductivity are used. Localization errors have been determined for 177 sources in 13 subjects. RESULTS: An average localization error of 10.6 (SD=5.5) mm for all 177 source was obtained for a skull conductivity ratio of 1/40. The average errors for the other ratios are only a few millimeters larger. The average localization error for 108 sources at superior locations in the brain is 9.2 (4.4) mm. The average error for 69 inferior location sources is 12.8 (6.2) mm. There are no significant differences in localization accuracy for deep and superficial sources. CONCLUSIONS: These results indicate that the best average localization that can be achieved using a spherical head model is approximately 10 mm. More realistic head models will be required for greater localization accuracy.


Subject(s)
Electroencephalography , Head/physiology , Algorithms , Electrodes, Implanted , Epilepsy/physiopathology , Humans , Models, Anatomic
8.
Epilepsy Behav ; 2(6): 545-557, 2001 Dec.
Article in English | MEDLINE | ID: mdl-12609388

ABSTRACT

Face perception and recognition is an intriguing ability, already present in neonates. Numerous studies in patients with brain lesions identified the temporo-occipital cortex as the crucial structure for this capacity. Analysis of electrical signals (EEG) inside the brain of patients implanted with intracranial electrodes for diagnostic purposes allows researchers to describe the temporal and spatial organization of responses to various aspects of face processing in human subjects. Several findings have emerged and appear relevant for cerebral organization in general: (1) Selective face responses were obtained from the basal temporo-occipital cortex at around 200 ms (N200); however, other structures such as the lateral temporal lobe and frontal cortex also participate in face recognition and perception tasks. (2) Each structure has a distinct "response profile"; that is, with respect to a given task certain structures respond strongly, others less or not at all. This profile might change with a different task, although the physical parameters of the stimuli remain the same. (3) The right hemispheric predominance of face processing, as suggested by patient data and studies in healthy volunteers, seemed to be restricted to its early stages (i.e., before 100-150 ms). (4) Recognition of faces might be associated with differential intracranial responses, despite an incorrect overt response, reflecting neurophysiological correlates of implicit memory. (5) The more the stimulus resembled a complete human face, the earlier and larger the N200 response was found, in particular over the basal temporobasal cortex. Analysis of electrical signals from intracranial electrodes might help to improve our understanding of the underlying physiological and anatomical constraints of cognitive processes.

9.
Brain Res ; 878(1-2): 223-7, 2000 Sep 29.
Article in English | MEDLINE | ID: mdl-10996157

ABSTRACT

We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures.


Subject(s)
Acetylcholinesterase/metabolism , Convulsants , Epilepsy, Generalized/chemically induced , Immunotoxins/pharmacology , N-Glycosyl Hydrolases , Neurons/drug effects , Plant Proteins/pharmacology , Prosencephalon/drug effects , Animals , Denervation , Disease Susceptibility , Flurothyl , Male , Neurons/enzymology , Neurons/pathology , Pentylenetetrazole , Prosencephalon/enzymology , Prosencephalon/pathology , Rats , Rats, Sprague-Dawley , Ribosome Inactivating Proteins, Type 1 , Saporins
10.
J Clin Neurophysiol ; 17(3): 331-5, 2000 May.
Article in English | MEDLINE | ID: mdl-10928645

ABSTRACT

The selection of which high-pass filter cutoff to use in P300 studies continues to be a serious methodological consideration. To determine whether there was an optimal range of bandpass widths-a range in which P300 voltage and latency would not show statistically significant differences-the authors recorded P300 responses to the auditory "oddball" paradigm from Cz and Pz electrodes in a group of eight healthy males. The authors used high-pass filter cutoffs of 0.01, 0.1, 0.3, and 1.0 Hz with low-pass filter cutoffs of 30 and 100 Hz and measured both P300 peak voltages and P300 integrated mean voltages at 12 bandpass settings. There were statistically significant differences in 7 out of 12 bandpass comparisons for P300 peak voltages and in 7 out of 12 bandwidth comparisons for P300 integrated mean voltages. For P300 latencies, there were statistically significant differences in 9 out of 12 bandwidth comparisons. Based on these results, the best recommendation, therefore, is that the high-pass filter be set no higher than 0.3 Hz.


Subject(s)
Cerebral Cortex/physiology , Electroencephalography , Event-Related Potentials, P300/physiology , Reaction Time/physiology , Adult , Artifacts , Humans , Male , Predictive Value of Tests , Reference Values
11.
Epilepsia ; 41(5): 536-41, 2000 May.
Article in English | MEDLINE | ID: mdl-10802758

ABSTRACT

PURPOSE: The occurrence of hypoxemia in adults with partial seizures has not been systematically explored. Our aim was to study in detail the temporal dynamics of this specific type of ictal-associated hypoxemia. METHODS: During long-term video/EEG monitoring (LTM), patients underwent monitoring of oxygen saturation using a digital Spo2 (pulse oximeter) transducer. Six patients (nine seizures) were identified with oxygen desaturations after the onset of partial seizure activity. RESULTS: Complex partial seizures originated from both left and right temporal lobes. Mean seizure duration (+/-SD) was 73 +/- 18 s. Mean Spo2 desaturation duration was 76 +/- 19 s. The onset of oxygen desaturation followed seizure onset with a mean delay of 43 +/- 16 s. Mean (+/-SD) Spo2 nadir was 83 +/- 5% (range, 77-91%), occurring an average of 35 +/- 12 s after the onset of the desaturation. One seizure was associated with prolonged and recurrent Spo2 desaturations. CONCLUSIONS: Partial seizures may be associated with prominent oxygen desaturations. The comparable duration of each seizure and its subsequent desaturation suggests a close mechanistic (possibly causal) relation. Spo2 monitoring provides an added means for seizure detection that may increase LTM yield. These observations also raise the possibility that ictal ventilatory dysfunction could play a role in certain cases of sudden unexpected death in epilepsy in adults with partial seizures.


Subject(s)
Epilepsies, Partial/metabolism , Hypoxia/blood , Oxygen/blood , Adult , Animals , Autonomic Nervous System Diseases/etiology , Autonomic Nervous System Diseases/physiopathology , Cricetinae , Death, Sudden/etiology , Electrocardiography , Electroencephalography , Epilepsies, Partial/blood , Epilepsies, Partial/physiopathology , Epilepsy, Temporal Lobe/blood , Epilepsy, Temporal Lobe/metabolism , Epilepsy, Temporal Lobe/physiopathology , Female , Humans , Hypoxia/metabolism , Hypoxia/physiopathology , Male , Middle Aged , Monitoring, Physiologic , Oximetry , Oxygen/metabolism , Respiration Disorders/etiology , Respiration Disorders/physiopathology
12.
J Clin Neurophysiol ; 17(1): 43-58, 2000 Jan.
Article in English | MEDLINE | ID: mdl-10709810

ABSTRACT

The ability to trigger functional magnetic resonance imaging (fMRI) acquisitions related to the occurrence of EEG-based physiologic transients has changed the field of fMRI into a more dynamically based technique. By knowing the temporal relationship between focal increases in neuronal firing rates and the provoked focal increase in blood flow, investigators are able to maximize the fMR-linked images that show where the activity originates. Our mastery of recording EEG inside the bore of a MR scanner has also allowed us to develop cognitive paradigms that record not only the fMR BOLD images, but also the evoked potentials (EPs). The EPs can subsequently be subjected to localization paradigms that can be compared to the localization seen on the BOLD images. These two techniques will most probably be complimentary. BOLD responses are dependent on a focal increase in metabolic demand while the EPs may or may not be related to energy demand increases. Additionally, recording EPs require that the source or sources of that potential come from an area that is able to generate far-field potentials. These potentials are related to the laminar organization of the neuronal population generating that potential. As best we know the BOLD response does not depend on any inherent laminar neuronal organization. Therefore, by merging these two recording methods, it is likely that we will gain a more detailed understanding of not only the areas involved in certain physiologic events, e.g. focal epilepsy or cognitive processing, but also on the sequencing of the activation of the various participating regions.


Subject(s)
Brain Diseases/diagnosis , Electroencephalography/methods , Epilepsy/etiology , Magnetic Resonance Imaging/methods , Artifacts , Brain Diseases/complications , Brain Diseases/physiopathology , Electrodes , Electroencephalography/instrumentation , Epilepsy/physiopathology , Equipment Design , Evoked Potentials/physiology , Humans , Image Enhancement/methods , Signal Processing, Computer-Assisted
13.
Epilepsy Res ; 39(1): 1-12, 2000 Mar.
Article in English | MEDLINE | ID: mdl-10690748

ABSTRACT

Autonomic changes accompany seizures in both animals and humans. While ictal autonomic dysfunction can be life-threatening, the participating neural networks involved are poorly understood. In this study we examined the activation of Fos following generalized seizures in brainstem structures known to mediate autonomic function. Adult female rats were sacrificed 2 h after flurothyl-induced seizures. Double-immunostaining for c-Fos and dopamine-beta-hydroxylase (DBH), and c-Fos and phenylethanol-N-methyl-transferase (PNMT) were performed in brainstem slices. Numbers of DBH-labeled neurons expressing Fos-like immunoreactivity (FLI) (DBH/Fos) and PNMT labeled neurons expressing FLI (PNMT/Fos) were counted in the noradrenergic (A1, A2, A5, A7) and adrenergic (C1, C2) cell groups localized in pons and medulla oblongata. Among the experimental animals, the highest degree of co-localization of DBH/Fos neurons was observed in the locus coeruleus (A6; 87.7%), and in the A1(72.8%) cell group located in the caudal ventrolateral medulla (VLM). No co-localization of DBH/Fos neurons was observed in control animals. The highest degree of co-localization of PNMT/Fos neurons was observed in the C1 adrenergic cell group (84.2%) located in the rostral VLM. Control animals showed very few (5.5%) PNMT/Fos co-localized neurons in the C1 adrenergic cell group. Our results indicate that flurothyl-induced generalized seizures in rats activate catecholaminergic neurons in the pons and medulla oblongata. Further studies are necessary to determine whether activation of brainstem catecholaminergic neurons contribute to the autonomic manifestations that frequently accompany epileptic seizures.


Subject(s)
Medulla Oblongata/metabolism , Neurons/metabolism , Pons/metabolism , Proto-Oncogene Proteins c-fos/metabolism , Seizures/metabolism , Animals , Convulsants , Dopamine beta-Hydroxylase/metabolism , Female , Flurothyl , Phenylethanolamine N-Methyltransferase/metabolism , Rats , Rats, Sprague-Dawley , Receptors, Catecholamine/metabolism , Seizures/chemically induced
14.
AJNR Am J Neuroradiol ; 20(10): 1916-9, 1999.
Article in English | MEDLINE | ID: mdl-10588118

ABSTRACT

BACKGROUND AND PURPOSE: The role of functional MR (fMR) imaging in the evaluation of patients with epilepsy has not been systematically studied. Our purpose was to identify the fMR correlates of interictal epileptiform discharges. METHODS: Twenty patients with epilepsy and frequent interictal discharges were studied with concurrent EEG monitoring on a 1.5-T echo-planar magnet to acquire blood-oxygenation-level-dependent (BOLD) images in the baseline (OFF) and immediate post-discharge (ON) states. Analysis was performed using subtraction of average ON and OFF data (method I); cross-correlation analysis between the ON and OFF states (method II); and individual spike analysis (ISA), with which signal intensity in the individual ON states was statistically analyzed using a weighted comparison with the mean and variance of the OFF states (method III). Agreement of fMR activation with EEG localization was determined. RESULTS: Eighteen of 20 patients had interictal discharges during the monitoring period. Method I yielded visually detectable sites of BOLD signal differences in only one patient. Method II resulted in two patients with sites of BOLD activation. Method III, ISA, resulted in regions of increased BOLD signal corresponding to the EEG focus in nine of 10 patients. CONCLUSION: fMR studies can often reveal sites of increased BOLD signal that correspond to sites of interictal EEG discharge activity. Because of variable intensity changes associated with discharge activity, ISA resulted in increased sensitivity.


Subject(s)
Echo-Planar Imaging , Electroencephalography , Epilepsy, Temporal Lobe/diagnosis , Image Enhancement , Image Processing, Computer-Assisted , Magnetic Resonance Imaging , Monitoring, Physiologic , Adult , Epilepsy, Temporal Lobe/physiopathology , Evoked Potentials/physiology , Female , Humans , Male , Oxygen/blood , Sensitivity and Specificity , Temporal Lobe/blood supply , Temporal Lobe/physiopathology
15.
Neurology ; 53(7): 1590-2, 1999 Oct 22.
Article in English | MEDLINE | ID: mdl-10534276

ABSTRACT

We report postictal heart rate oscillations in a heterogeneous group of patients with partial epilepsy. This pattern is marked by the appearance of transient but prominent low-frequency heart rate oscillations (0.01 to 0.1 Hz) immediately after 5 of 11 seizures recorded in 5 patients. This finding may be a marker of neuroautonomic instability and, therefore, may have implications for understanding perturbations of heart rate control associated with partial seizures.


Subject(s)
Epilepsies, Partial/physiopathology , Heart Rate , Adult , Electrocardiography , Electroencephalography , Humans , Middle Aged , Oscillometry
16.
Epilepsia ; 40(9): 1254-60, 1999 Sep.
Article in English | MEDLINE | ID: mdl-10487189

ABSTRACT

PURPOSE: Focal status epilepticus is typically diagnosed by the observation of continuous jerking motor activity, but many other manifestations have been described. EEG evidence of focal status may take several forms, and their interpretation is controversial. We detailed the clinical spectrum of focal status in patients diagnosed by both clinical deficit and EEG criteria and contrasted clinical manifestations in patients with different EEG patterns. METHODS: Patients were diagnosed with a neurologic deficit and discrete recurrent focal electrographic seizures or rapid, continuous focal epileptiform discharges on EEG. Clinical findings were determined by chart review. RESULTS: Of 41 patients with focal status, acute vascular disease was the cause in 21; 10 of 41 had exacerbations of prior epilepsy. A variety of clinical seizure types occurred, both before and after the EEG diagnosis, but the diagnosis was not expected in 28 patients before the EEG. Three had no obvious clinical seizures. Focal motor seizures and an abnormal mental status were the most common manifestations at the time of the EEG. With antiepileptic drugs, almost all had control of clinical seizures, and most improved in mental status. Patients with rapid continuous focal epileptiform discharges were nearly identical in presentation, likelihood of diagnosis, subsequent seizures, response to medication, and outcome to those with discrete seizures on EEG. CONCLUSIONS: Focal status epilepticus may be seen with a wide variety of clinical seizure types or without obvious clinical seizures. The diagnosis is often delayed or missed and should be considered after strokes or clinical seizures when patients do not stabilize or improve as expected. The diagnosis should be made equally whether patients have discrete electrographic seizures or continuous rapid focal epileptiform discharges on the EEG, and the same response to medications and outcome should be anticipated for the two groups.


Subject(s)
Electroencephalography/statistics & numerical data , Epilepsies, Partial/diagnosis , Status Epilepticus/diagnosis , Adolescent , Adult , Aged , Anticonvulsants/therapeutic use , Cerebral Cortex/physiopathology , Cerebrovascular Disorders/diagnosis , Cerebrovascular Disorders/physiopathology , Diagnosis, Differential , Epilepsies, Partial/drug therapy , Epilepsies, Partial/physiopathology , Female , Humans , Male , Middle Aged , Outcome Assessment, Health Care , Status Epilepticus/drug therapy , Status Epilepticus/physiopathology
18.
Epilepsy Res ; 34(1): 49-55, 1999 Mar.
Article in English | MEDLINE | ID: mdl-10194112

ABSTRACT

The inferior colliculus (IC) plays a key role in modulating audiogenic seizures (AS) in rats. We investigated whether acoustic brainstem nuclei express Fos-like immunoreactivity (FLI) after flurothyl-induced generalized seizures in rats. Compared to controls, experimental animals showed significantly (P<0.05) more FLI in the dorsal and external cortex of the IC, as well as in the medial part of the medial geniculate body (MGB), perigeniculate area, and dorsal cochlear nucleus. No significant increase of FLI was observed in the central nucleus of the IC, ventral and dorsal parts of the MGB, dorsal nucleus of the lateral lemniscus, or ventral cochlear nucleus. Because this pattern of FLI closely resembles that observed after AS in previous studies, these results suggest that Fos expression in acoustic brainstem nuclei is not specific for AS.


Subject(s)
Auditory Pathways/metabolism , Brain Stem/metabolism , Convulsants , Epilepsy, Generalized/chemically induced , Epilepsy, Generalized/metabolism , Flurothyl , Proto-Oncogene Proteins c-fos/metabolism , Animals , Auditory Pathways/pathology , Brain Stem/pathology , Female , Immunohistochemistry , Neurons/metabolism , Rats , Rats, Sprague-Dawley , Tissue Distribution/physiology
19.
Am J Clin Nutr ; 68(3): 531-7, 1998 Sep.
Article in English | MEDLINE | ID: mdl-9734727

ABSTRACT

BACKGROUND: Neurobehavioral symptoms have been reported anecdotally with aspartame. OBJECTIVE: This study sought to determine whether aspartame can disrupt cognitive, neurophysiologic, or behavioral functioning in normal individuals. DESIGN: Forty-eight healthy volunteers completed a randomized, double-blind, placebo-controlled, crossover study. The first month was aspartame free. Subjects then consumed sodas and capsules with placebo, aspartame, or sucrose for 20 d each. Order was randomized and subjects were assigned to either a high- (45 mg x kg body wt(-1) x d(-1)) or low- (15 mg x kg body wt(-1) x d(-1)) dose aspartame group. Neuropsychologic and laboratory testing was done on day 10 of each treatment period to determine possible acute effects and on day 20 for possible chronic effects. RESULTS: Plasma phenylalanine concentrations increased significantly during aspartame treatment. Neuropsychologic results; adverse experiences; amino acid, insulin, and glucose values; and electroencephalograms were compared by sex and by treatment. No significant differences were found for any dependent measure. CONCLUSION: Large daily doses of aspartame had no effect on neuropsychologic, neurophysiologic, or behavioral functioning in healthy young adults.


Subject(s)
Aspartame/adverse effects , Behavior/drug effects , Cognition/drug effects , Nervous System/drug effects , Adult , Aspartame/administration & dosage , Blood Glucose/drug effects , Cross-Over Studies , Dose-Response Relationship, Drug , Double-Blind Method , Electroencephalography/drug effects , Humans , Male , Phenylalanine/blood , Psychological Tests
20.
J Clin Neurophysiol ; 15(3): 251-5, 1998 May.
Article in English | MEDLINE | ID: mdl-9681563

ABSTRACT

The incidences of spikes and paroxysmal rhythmic events (PREs) in 10-h overnight EEGs of normal adult volunteers (n=135) were studied at 11 sites with a computer-assisted ambulatory EEG monitoring system with automatic spike and PRE detection. Spikes were evident in the overnight EEG of 1 subject (0.7%), and PREs were apparent in the overnight EEG of the same subject (0.7%). The incidences of spikes of 24 other subjects with a history of migraine and/or a family history of epilepsy were 12.5 and 13.3%, respectively. The overnight EEGs of these subjects were significantly more likely to show spikes than the overnight EEGs of subjects without migraine or a family history of epilepsy.


Subject(s)
Electroencephalography/instrumentation , Epilepsy/diagnosis , Migraine Disorders/diagnosis , Monitoring, Physiologic/instrumentation , Signal Processing, Computer-Assisted/instrumentation , Adolescent , Adult , Aged , Ambulatory Care , Brain Mapping/instrumentation , Cerebral Cortex/physiopathology , Epilepsy/genetics , Epilepsy/physiopathology , Evoked Potentials/physiology , Female , Humans , Male , Middle Aged , Migraine Disorders/genetics , Migraine Disorders/physiopathology , Reference Values
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