Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Database
Language
Publication year range
1.
Arch Intern Med ; 145(8): 1513-5, 1985 Aug.
Article in English | MEDLINE | ID: mdl-4026479

ABSTRACT

A patient is described with cholestatic hepatitis following the use of carbimazole. A liver biopsy specimen showed intracanalicular cholestasis and some mononuclear cell infiltrate in the portal triades, consistent with drug toxicity; indications of an autoimmune or viral pathogenesis were absent. Rechallenge with the drug precipitated jaundice and disturbed liver function once more. Carbimazole induced a blastogenic response of patient lymphocytes in vitro. Both may suggest the involvement of an immune-mediated reaction, especially as it has been shown that sensitized lymphocytes may produce a cholestatic factor on stimulation with antigen.


Subject(s)
Carbimazole/adverse effects , Cholestasis, Intrahepatic/chemically induced , Aged , Bile Ducts/immunology , Cholestasis, Intrahepatic/immunology , Cholestasis, Intrahepatic/pathology , DNA/biosynthesis , Female , Humans , Liver/enzymology , Liver/pathology , Lymphocyte Activation/drug effects , Lymphocytes/drug effects , Lymphocytes/immunology
SELECTION OF CITATIONS
SEARCH DETAIL
...