1.
Arch Intern Med
; 145(8): 1513-5, 1985 Aug.
Article
in English
| MEDLINE
| ID: mdl-4026479
ABSTRACT
A patient is described with cholestatic hepatitis following the use of carbimazole. A liver biopsy specimen showed intracanalicular cholestasis and some mononuclear cell infiltrate in the portal triades, consistent with drug toxicity; indications of an autoimmune or viral pathogenesis were absent. Rechallenge with the drug precipitated jaundice and disturbed liver function once more. Carbimazole induced a blastogenic response of patient lymphocytes in vitro. Both may suggest the involvement of an immune-mediated reaction, especially as it has been shown that sensitized lymphocytes may produce a cholestatic factor on stimulation with antigen.
Subject(s)
Carbimazole/adverse effects , Cholestasis, Intrahepatic/chemically induced , Aged , Bile Ducts/immunology , Cholestasis, Intrahepatic/immunology , Cholestasis, Intrahepatic/pathology , DNA/biosynthesis , Female , Humans , Liver/enzymology , Liver/pathology , Lymphocyte Activation/drug effects , Lymphocytes/drug effects , Lymphocytes/immunology
2.
Neth J Med
; 25(5): 121-6, 1982.
Article
in English
| MEDLINE
| ID: mdl-7099315
3.
Isr J Med Sci
; 8(6): 832-4, 1972 Jun.
Article
in English
| MEDLINE
| ID: mdl-5051811
Subject(s)
Aging , Glucose Tolerance Test , Insulin/metabolism , Lipids/blood , Adipose Tissue/metabolism , Adult , Blood Glucose , Body Weight , Fasting , Fatty Acids, Nonesterified/blood , Female , Glycerol/blood , Humans , Insulin/blood , Insulin Resistance , Insulin Secretion , Male , Time Factors
4.
Acta Physiol Pharmacol Neerl
; 14(4): 523, 1967 Dec.
Article
in English
| MEDLINE
| ID: mdl-5582727
