Outcomes of Continuous Renal Replacement Therapy in a Community Health System.

OBJECTIVE: Continuous renal replacement therapy (CRRT) is commonly used in critically ill, hemodynamically unstable patients with acute kidney injury (AKI). This procedure is resource intensive with reported high in-hospital mortality. We evaluated mortality with CRRT in our healthcare system and markers associated with decreased survival. METHODS: A retrospective cohort study collected data on patients 18 years or older, without prior history of end stage kidney disease (ESKD), who received CRRT in the intensive care units at one of three hospitals in our health system in Columbus, OH from July 1, 2016 to July 1, 2019. Data included demographics, presenting diagnosis, comorbidities, laboratory markers, and patient disposition. In-hospital mortality rates and sequential organ failure assessment (SOFA) scores were calculated. We then compared information between two groups (patients who died during hospitalization and survivors) using univariate comparisons and multivariate logistic regression models. RESULTS: In-hospital mortality was 56.8% (95%CI: 53.4-60.1) among patients who received CRRT. Mean SOFA scores did not differ between survival and mortality groups. The odds for in-patient mortality were increased for patients age ≥60 (OR = 1.74, 95%CI: 1.23-2.44), first bilirubin >2 mg/dL (OR = 1.73, 95%CI: 1.12-2.69), first creatinine < 2 mg/dL (OR = 1.57, 95%CI: 1.04-2.37), first lactate > 2 mmol/L (OR = 2.08, 95%CI: 1.43-3.04). The odds for in-patient mortality were decreased for patients with cardiogenic shock (OR = .32, 95%CI: .17-.58) and hemorrhagic shock (OR = .29, 95%CI: .13-.63). CONCLUSIONS: We report in-hospital mortality rates of 56.8% with CRRT. Unlike prior studies, higher mean SOFA scores were not predictive of higher in-hospital mortality in patients utilizing CRRT.

A retrospective analysis of lesser metatarsophalangeal joint fusion as a treatment option for hammertoe pathology associated with metatarsophalangeal joint instability.

Complex hammer digit deformity is commonly associated with instability of the metatarsophalangeal joint. Restoring joint stability is critical for digit alignment and function and can be challenging and unpredictable. Lesser metatarsophalangeal joint fusion might be an alternative treatment to the current soft tissue balancing, repair, and extra-articular osseous procedures used to treat joint instability. The present study was a retrospective chart and radiographic review of the pooled outcomes of 31 consecutive lesser metatarsophalangeal joint fusion procedures performed by 3 independent surgeons from May 2004 to September 2009. The clinical and radiographic outcomes were analyzed with descriptive and inferential statistics. The overall interval to radiographic union was 8.69 ± 1.7 weeks (range 6 to 12 and 95% confidence interval 7.9 to 9.4). The overall period to clinical union was 10.25 ± 4.5 weeks (range 4 to 22 and 95% confidence interval 8.5 to 11.9). The mean duration of non-weight-bearing was 4.71 ± 1.74 weeks, followed by 5.09 ± 2.8 weeks of guarded weight-bearing with a brace. Complications included nonunion in 4 (12.90%), hardware breakage in 2 (6.45%), and soft tissue infection in 1 (3.23%). Patients demonstrated a statistically significant reduction in pain (p = .035) and improved digit alignment after the procedure that enabled full return to unrestricted weight-bearing activities without limitations or the need for orthoses. These findings support metatarsophalangeal joint fusion as an alternative treatment of lesser digit metatarsophalangeal joint instability associated with hammer digit deformities that obviate the need for concomitant soft tissue procedures such as plantar plate repair or tendon balancing procedures.

Continuous haematocrit monitoring during intradialytic hypotension: precipitous decline in plasma refill rates.

BACKGROUND: Intradialytic hypotension (IDH) during ultrafiltration remains a major source of haemodialysis related morbidity, despite technological advances including continuous haematocrit monitoring and automated blood volume controlled dialysis machines. We hypothesized that studying the relationship between ultrafiltration rate and plasma refill rate (UFR, PRR) before and during IDH would provide insight into its mechanism and possible prevention. METHODS: We retrospectively identified 17 patients (mean age 50 years) with IDH treated solely by turning off the ultrafiltration, none having received hypertonic saline, mannitol or albumin. All patients had archived data for continuous haematocrits, UFR, ultrafiltration goal, vital signs and symptoms. We used the Crit-Line III optical haematocrit monitor to calculate the PRR for intervals preceding and during IDH. RESULTS: Prior to IDH the PRR was 1360+/-550 ml/h; which was less than the UFR of 1471+/-602 ml/h and was associated with a 4.4% rise in haematocrit. However, during IDH the PRR was dramatically lower (P<0.001): only 242+/-151 ml/h. The PRR was not correlated (P>0.05) with the absolute, per cent change or rate of rise in haematocrit, UFR, ultrafiltration goal or heart rate. CONCLUSIONS: On-line haematocrit monitoring allows for the calculation of plasma volume changes, UFR and PRR, and the mismatch in those rates helps explain the physiology of hypotension episodes. The precipitous fall in PRR during sudden IDH supports activation of the cardiodepressor Bezold-Jarisch reflex. As both the UFR and PRR variables can change during a single dialysis session, this supports the use of devices with automated continuous adjustments of the UFR and suggests additional profiling methodologies.