1.
Clin Transl Sci
; 10(2): 78-83, 2017 03.
Article
in English
| MEDLINE
| ID: mdl-28160443
Subject(s)
Drug Discovery/methods , Genetic Predisposition to Disease , Genomics/methods , Pharmacogenomic Variants , Precision Medicine/methods , Clinical Decision-Making , Diffusion of Innovation , Drug Discovery/trends , Drug Dosage Calculations , Drug-Related Side Effects and Adverse Reactions/genetics , Drug-Related Side Effects and Adverse Reactions/metabolism , Drug-Related Side Effects and Adverse Reactions/prevention & control , Forecasting , Genomics/trends , Humans , Molecular Targeted Therapy/methods , Patient Safety , Patient Selection , Phenotype , Precision Medicine/trends , Predictive Value of Tests , Risk Assessment , Risk Factors
2.
Clin Pharmacol Ther
; 97(3): 218-20, 2015 Mar.
Article
in English
| MEDLINE
| ID: mdl-25669642
ABSTRACT
Drug development is increasingly global. The benefits of multiregional trials include worldwide evaluation of safety and efficacy. However, clinical practice, environmental, and genetic factors can vary across geographic regions, significantly influencing trial outcomes within a specific geographic region or the global population relative to the United States (US). Genomic technologies and research discoveries continue to advance at a remarkable pace, offering opportunities to explore intrinsic factors that could account for regional variability in drug pharmacokinetics or response.
