ABSTRACT
One key aspect of allogeneic hematopoietic cell transplantation (HCT) is pretransplant conditioning, balancing risk for relapse versus non-relapse mortality. Conditioning regimens with different alkylators at different doses can influence outcome, but data are missing for myelofibrosis, a challenging cohort of patients usually presenting at older age and with comorbidities. We evaluated in a multicenter retrospective study the comparative efficacy and safety of busulfan versus treosulfan in combination with fludarabine for myelofibrosis patients undergoing HCT. This study included 1115 patients (busulfan, n = 902; treosulfan, n = 213) receiving first HCT between 2005 and 2021. Patients were generally balanced for key patient characteristics. Overall survival at 4 years was 62% for the busulfan group versus 58% for the treosulfan group (p = .22). Impact on outcome was dose-dependent. Overall survival was 65% (95% CI, 61%-69%) for reduced intensity busulfan versus 69% (95% CI, 54%-84%) for reduced intensity treosulfan, 53% (95% CI, 44%-63%) for higher intensity busulfan, and 55% (95% CI, 46%-63%) for higher intensity treosulfan. Incidence of relapse was similar across intensity groups. In multivariable analysis, the hazard for death (with reduced intensity busulfan as reference) was 0.88 (95% CI, 0.39-2.01) for reduced intensity treosulfan (p = .77), 1.42 (95% CI, 0.96-2.10) for higher intensity busulfan (0.08), and 1.61 (95% CI, 1.14-2.26) for higher intensity treosulfan (p = .006). In terms of non-relapse mortality, comparison was not significantly different, while the hazard ratio for higher intensity treosulfan was 1.48 (95% CI, 0.98-2.23; p = .06). Here, we showed comparable outcomes and improved survival in myelofibrosis undergoing HCT with reduced intensity busulfan or treosulfan.
Subject(s)
Busulfan , Hematopoietic Stem Cell Transplantation , Primary Myelofibrosis , Transplantation Conditioning , Vidarabine , Busulfan/analogs & derivatives , Busulfan/administration & dosage , Busulfan/therapeutic use , Humans , Primary Myelofibrosis/therapy , Primary Myelofibrosis/mortality , Primary Myelofibrosis/drug therapy , Middle Aged , Male , Female , Transplantation Conditioning/methods , Retrospective Studies , Aged , Adult , Vidarabine/analogs & derivatives , Vidarabine/administration & dosage , Vidarabine/therapeutic use , Antineoplastic Agents, Alkylating/therapeutic use , Antineoplastic Agents, Alkylating/administration & dosage , Young AdultABSTRACT
INTRODUÇÃO: A Incontinência Urinária (IU) é definida como qualquer perda involuntária de urina. O aumento do peso e as medidas de circunferências elevadas são fatores de risco para o desenvolvimento destes sintomas. OBJETIVO: Avaliar a influência das variáveis antropométricas (VAs) na força muscular do assoalho pélvico de mulheres com IU. MATERIAIS E MÉTODOS: Estudo transversal com amostragem de conveniência. Iniciada a avaliação com a anamnese, após aferição das VAs seguiu-se para avaliação funcional do assoalho pélvico (AFA). Aplicada correlação de Spearman, e para avaliar a influência das VAs na AFA realizou-se regressão linear múltipla. RESULTADOS: Avaliadas 12 voluntárias com IU, média de idade 56,9±13,2 anos e maior frequência 10 (83,3%) de incontinência urinária de esforço. Encontradas correlações moderadas e negativas entre VAs e a AFA [Índice de massa corporal (IMC) vs AFA (r= -0,582 p=0,020); Circunferência da Cintura (CC) vs AFA (r= -0,567 p=0,033); Circunferência do Quadril (CQ) vs AFA (r= -0,593 p=0,050); Circunferência Abdominal (CA) vs AFA (r= -0,657 p=0.001)]. Estes achados foram ratificados através da análise de regressão linear múltipla, onde há influência direta de 37% do IMC e CA na AFA das voluntárias com IU. CONCLUSÃO: Valores elevados das VAs estão relacionadas diretamente com um pior desempenho na AFA, em mulheres com incontinência urinária. [AU]
INTRODUCTION: Urinary Incontinence (UI) is defined as any involuntary loss of urine, weight gain and high circumference measures are risk factors for UI symptoms development. OBJECTIVE: To evaluate the influence of anthropometric variables on the pelvic floor muscular strength of women with UI. METHODS AND MATERIALS: Cross-sectional study with convenience sample. Data were collected during anamnesis and after obtaining anthropometric variables, pelvic floor functional evaluation (PFE) was done. A Spearman correlation was performed and to evaluate anthropometrics variables' influence on PFE we did a multiple linear regression. RESULTS: 12 volunteers with UI were evaluated, mean age of 56.9±13.2 years with a frequency of 10 (83.3%) with stress urinary incontinence. Moderate and negative correlations between anthropometrics variables and PFE were found [Body mass index (BMI) vs PFE (r= -0,582 p=0,020); Waist circumference (WC) vs PFE (r= -0.567 p=0.033); Hip circumference (HC) vs PFE (r= -0.593 p=0.050); Abdominal circumference (AC) vs PFE (r= -0.657 p=0.001)]. The correlations findings can be ratified through a multiple linear regression analysis, where there is a direct influence of 37% of BMI and AC on PFE in the volunteers with UI. CONCLUSION: Higher values of the anthropometric measures are directly related to a worse performance on PFE, High VA values are directly related to poor performance in AFA in women with urinary incontinence. [AU]
Subject(s)
Urinary Incontinence , Body Mass Index , Pelvic FloorABSTRACT
O artigo descreve o importante papel da ética na formação dos profissionais da saúde. Inicia com considerações sobre o nascimento e incorporação da bioética na formação do profissional da saúde, destacando o papel das instituições de ensino superior na disseminação de conteúdos éticos pertinentes a cada profissão. É destacado o papel do ensino da ética na formação dos profissionais da área da saúde, tecendo considerações sobre da importância desse ensinamento que visa à humanização da prática médica.
