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1.
Regul Toxicol Pharmacol ; 124: 104965, 2021 Aug.
Article in English | MEDLINE | ID: mdl-34038774

ABSTRACT

In an experimental setting a laboratory analysis of substances migrating from UV prints under mechanical stress into sweat and saliva simulant was performed. The influence of paper type and curing degree on UV prints was investigated. Five substances were identified at concentrations above the limit of detection in the simulants PPG-3 glyceryl triacrylate, ethoxylated trimethylolpropane triacrylate, trimethylolpropane triacrylate, 2/4-isopropylthioxanthone (ITX), and 2,4-diethylthioxanthone (DETX). Migration of the acrylates and photoinitiators into saliva and sweat simulants were increased when the UV inks were printed on uncoated paper in comparison to coated paper. With an exposure scenario considering a person to leaf through 80 pages of UV-printed paper per day while touching each page with a licked fingertip, Risk Characterisation Ratios (RCR) for oral exposure well below 1 were obtained for all five substances indicating no risk for the general population. The three acrylates are classified for skin sensitisation. The migrated amounts per skin surface area of these three were compared with the EC3 value for a hypothetical substance that could be categorised as strong sensitiser (EC3 = 0.1%). The results show that the risk of skin sensitisation even under worst case conditions can be considered as negligible.


Subject(s)
Acrylates/toxicity , Ink , Printing/methods , Ultraviolet Rays , Acrylates/pharmacokinetics , Acrylates/radiation effects , Adult , Computer Simulation , Humans , Models, Biological , Permeability , Printing/instrumentation , Saliva/metabolism , Skin/metabolism , Sweat/metabolism
2.
Crit Rev Toxicol ; 39(4): 271-98, 2009.
Article in English | MEDLINE | ID: mdl-19235533

ABSTRACT

Inorganic arsenic, which is extensively metabolised in humans into even more toxic methylated arsenicals, is a potent carcinogen, causing tumours of the skin, lung, urinary bladder, and other organs. It also induces a number of non-cancer effects. Consumption of drinking water highly contaminated by arsenic causes serious health problems in some countries in southeastern Asia, and arsenic poses problems for drinking-water safety world-wide. Existing risk assessments are based on epidemiological studies from regions with high exposure concentrations (in the mg/L range). It is a matter of debate whether these findings are useful at predicting arsenic-induced effects at low concentrations. In recent years numerous epidemiological studies on cancer and non-cancer effects of inorganic arsenic have been published. This work aims at reviewing recent toxicological and epidemiological data on inorganic arsenic with emphasis on effects at low exposure concentrations. Information obtained from epidemiological studies is supplemented with mechanistic data from in vitro and in vivo studies. Various modes of action for arsenic carcinogenicity are discussed. The information gathered was used to evaluate the reliability of existing cancer-risk assessments and to improve current assessments of non-cancer health effects. A tolerable daily dose, based on epidemiological studies on arsenic-induced skin disorders, is presented.


Subject(s)
Arsenic Poisoning , Arsenic/adverse effects , Carcinogens/toxicity , Neoplasms/chemically induced , Water Supply , Arsenic Poisoning/etiology , Arsenic Poisoning/metabolism , Risk Assessment , Skin Diseases/chemically induced , Water Pollutants/adverse effects
3.
Food Addit Contam ; 24(7): 768-76, 2007 Jul.
Article in English | MEDLINE | ID: mdl-17613062

ABSTRACT

Environmental contaminants originate from diverse sources and, owing to their ubiquitous presence in the environment, may appear in foods. Setting standards in food is increasingly important within the European Union and world-wide to protect consumers' health and to avoid trade barriers. This paper analyses how maximum levels for environmental contaminants in food were derived by the Codex Alimentarius Commission, by the European Union and by national authorities (USA, Germany). Both the risk assessment process (derivation of tolerable intake values and intake assessment by scientific bodies) and the risk management process (derivation of maximum levels by risk management bodies) are discussed. The various organizations show similar approaches and similar numerical values for maximum levels of the same contaminants in the same food items. In the area of decision-making for risk management, there was a noticeable lack of transparency in all the investigated systems. Recommendations are made for the development and harmonization of exposure assessment and communications between risk assessment and risk management processes, for improvements in documentation and for greater transparency within risk management decision-making processes.


Subject(s)
Environmental Exposure/legislation & jurisprudence , Food Contamination/legislation & jurisprudence , Public Health Practice/legislation & jurisprudence , Risk Assessment/methods , Decision Making , Environmental Exposure/prevention & control , Europe , Food Contamination/prevention & control , Maximum Allowable Concentration
4.
Regul Toxicol Pharmacol ; 37(1): 92-104, 2003 Feb.
Article in English | MEDLINE | ID: mdl-12662913

ABSTRACT

Uncertainty in risk assessment results from the lack of knowledge on toxicity to the target population for a substance. Currently used deterministic risk assessment methods yield human limit values or margins of safety (MOS) without quantitative measurements of uncertainty. Qualitative and quantitative uncertainty analysis would enable risk managers to better judge the consequences of different management options. This article discusses sources of uncertainty and possibilities for quantification of uncertainty associated with different steps in the risk assessment of non-carcinogenic health effects. Knowledge gaps causing uncertainty in risk assessment are overcome by extrapolation. Distribution functions for extrapolation factors are based on empirical data and provide information about the extent of uncertainty introduced by these factors. Whereas deterministic methods can account only qualitatively for uncertainty of the resulting human limit value, probabilistic risk assessment methods are able to quantify several aspects of uncertainty. However, there is only limited experience with these methods in practice. Their acceptance and future application will depend on the establishment of evidence based distribution functions, flexibility and practicability of the methods, and the unambiguity of the results.


Subject(s)
Drug-Related Side Effects and Adverse Reactions , Health , Risk Assessment/methods , Uncertainty , Animals , Humans , Models, Statistical , Pharmaceutical Preparations , Risk Assessment/statistics & numerical data , Species Specificity
5.
Regul Toxicol Pharmacol ; 36(3): 221-33, 2002 Dec.
Article in English | MEDLINE | ID: mdl-12473407

ABSTRACT

Carcinogenic air contaminants are assigned to emission classes with different emission limits on the basis of their inhalation carcinogenic potency within the revised form of the German First General Administrative Regulation Pertaining to the Federal Emission Control Law (Technical Instructions on Air Quality Control-TA Luft). Accordingly, compounds with high carcinogenic potency are regulated more strictly than less potent substances. The data on carcinogenic properties are heterogeneous. Twenty-five substances or substance groups have been scrutinized and a procedure has been developed to rank these chemicals according to their carcinogenic potency. For 14 substances well-founded unit risk estimates were available to allow assignment of these air contaminants to emission classes. Unit risk estimates for bromoethane, 2-butanone oxime, and o-toluidine were derived using the ED(10)/LED(10) method based on animal studies. For several substances no qualified unit risk estimates or carcinogenicity studies were available to estimate carcinogenic potency after inhalation. Carcinogenic potency of these substances was approximated using two simple methods, T25 and CELmin.


Subject(s)
Air Pollutants/adverse effects , Air Pollutants/classification , Carcinogens/adverse effects , Carcinogens/classification , Inhalation Exposure , Humans , Risk Assessment
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