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Clin Lab ; 47(11-12): 549-54, 2001.
Article in English | MEDLINE | ID: mdl-11759956

ABSTRACT

The performance of an improved version of the troponin T rapid test TROPT Sensitive was investigated in a multicentre evaluation at twelve centres. The detection limit and the cut-off were determined in a method comparison with Elecsys Troponin T using a total of 365 samples from patients with suspected acute coronary syndromes and 91 samples from healthy blood donors or non-cardiological patients. The analytical specificity was determined by measuring 1271 blood samples from blood donors without any myocardial injury. The test cut-off (90% of results positive) is 0.08 microg/L, and the detection limit is about 0.05 microg/L. The analytical specificity of the test is between 99.7 and 99.9%. With its small area of undefined significance between positive and negative results and its high sensitivity and specificity, TROPT Sensitive is very well suited to the reliable detection of troponin T positive patients with acute coronary syndromes.


Subject(s)
Coronary Disease/diagnosis , Reagent Kits, Diagnostic/standards , Troponin T/blood , Biomarkers/blood , Coronary Disease/blood , Humans , Myocardium/chemistry , Regression Analysis , Sensitivity and Specificity , Time Factors
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