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Membrane-anchored peptide inhibits human immunodeficiency virus entry.
Hildinger, M; Dittmar, M T; Schult-Dietrich, P; Fehse, B; Schnierle, B S; Thaler, S; Stiegler, G; Welker, R; von Laer, D.
J Virol ; 75(6): 3038-42, 2001 Mar.
Article in English | MEDLINE | ID: mdl-11222732

ABSTRACT

Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.


Subject(s)
HIV Envelope Protein gp41/physiology , HIV-1/physiology , Peptide Fragments/physiology , T-Lymphocytes, Helper-Inducer/virology , Amino Acid Sequence , Cell Line , Cell Membrane/metabolism , Enfuvirtide , Genetic Vectors , HIV Envelope Protein gp41/chemistry , HIV Envelope Protein gp41/genetics , HIV Envelope Protein gp41/metabolism , Humans , Molecular Sequence Data , Peptide Fragments/chemistry , Peptide Fragments/genetics , Peptide Fragments/metabolism , Retroviridae/genetics , Transduction, Genetic , Virus Replication
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