ABSTRACT
INTRODUCTION AND OBJECTIVE: Thermal injuries associated with Holmium laser lithotripsy of the urinary tract are an underestimated problem in stone therapy. Surgical precision relies exclusively on visual target identification when applying laser energy for stone disintegration. This study evaluates a laser system that enables target identification automatically during bladder stone lithotripsy, URS, and PCNL in a porcine animal model. METHODS: Holmium laser lithotripsy was performed on two domestic pigs by an experienced endourology surgeon in vivo. Human stone fragments (4-6 mm) were inserted in both ureters, renal pelvises, and bladders. Ho:YAG laser lithotripsy was conducted as a two-arm comparison study, evaluating the target identification system against common lithotripsy. We assessed the ureters' lesions according to PULS and the other locations descriptively. Post-mortem nephroureterectomy and cystectomy specimens were examined by a pathologist. RESULTS: The sufficient disintegration of stone samples was achieved in both setups. Endoscopic examination revealed numerous lesions in the urinary tract after the commercial Holmium laser system. The extent of lesions with the feedback system was semi-quantitatively and qualitatively lower. The energy applied was significantly less, with a mean reduction of more than 30% (URS 27.1%, PCNL 52.2%, bladder stone lithotripsy 17.1%). Pathology examination revealed only superficial lesions in both animals. There was no evidence of organ perforation in either study arm. CONCLUSIONS: Our study provides proof-of-concept for a laser system enabling automatic real-time target identification during lithotripsy on human urinary stones. Further studies in humans are necessary, and to objectively quantify this new system's advantages, investigations involving a large number of cases are mandatory.
Subject(s)
Lithotripsy, Laser/methods , Ureteroscopy , Urinary Bladder Calculi/therapy , Animals , Female , SwineABSTRACT
INTRODUCTION: For decades, automatic speech recognition (ASR) has been the subject of research and its range of applications broadened. Presently, ASR among physicians is mainly used to convert speech into text but not to implement instructions in the operating room (OR). This study aimed to evaluate physicians of different surgical professions on their personal experience and posture towards ASR. METHODS: A 16-item survey was distributed electronically to hospitals and outpatient clinics in southern Germany addressing physicians on the potential applications of ASR in the OR. RESULTS: The survey was responded by 185 of 2693 physicians (response rate: 6.9%) with a mean age of 41.8 ± 9.8 years. ASR is desirable in the OR regardless of the field of speciality (93.7%). While only 2.7% have used ASR, 87.9% evaluate its future potential as high. 91.0% of those working in a university hospital would consider testing ASR, while 67.5% of those in non-university hospitals and practices (p = 0.001). 90.1% of responders of strictly surgical specialities see potential in ASR while 73.7% in non-surgical specialities evaluate its future potential as high (p = 0.01). 58.3% of those over the age of 60 consider the use of ASR without a headset to be imaginable, while 96.3% among those under the age of 60. There were no statistically significant differences regarding sex and professional position. CONCLUSION: Foreseeably, ASR is anticipated to be integrated into ORs and valued at a high market potential. Our study provides information about physicians' individual preferences from various surgical disciplines regarding ASR.
ABSTRACT
BACKGROUND: We evaluated the influence of comorbidity inferred risks for lymph node metastasis (pN1) and positive surgical margins (R1) after radical prostatectomy in order to optimize pretherapeutic risk classification. We analyzed 454 patients after radical prostatectomy (RP) between 2009 and 2014. Comorbidities were defined by patients' medication from our electronic patient chart and stratified according to the ATC WHO code. Endpoints were lymph node metastasis (pN1) and positive surgical margins (R1). RESULTS: Rates for pN1 and R1 were 21.4% (97/454) and 29.3% (133/454), respectively. In addition to CAPRA and Gleason score, we identified diabetes as a significant medication inferred risk factor for pN1 (OR 2.9, p = 0.004/OR 3.2, p = 0.001/OR 3.5, p = 0.001) and beta-blockers for R1 (OR 1.9, p = 0.020/OR 2.9, p = 0.004). Patients with diabetes showed no statistically significant difference in Gleason score, CAPRA Score, PSA, and age compared to non-diabetic patients. CONCLUSIONS: We identified diabetes and beta1 adrenergic blockage as significant risk factors for lymph node metastasis and positive surgical margins in prostate cancer (PCa). Patients at risk will need intensive pretherapeutic staging for optimal therapeutic stratification.
