Subject(s)
Burkitt Lymphoma/drug therapy , Fertilization , Ovarian Neoplasms/drug therapy , Adult , Female , Humans , Live Birth , PregnancyABSTRACT
Endometrial cell clones derived from in vitro cultured purified stromal cells obtained by endometrial biopsy display characteristic stem cell features, including clonality; long-term culturing properties; multilineage differentiation potential; expression of CD146, CD105, CD90, CD73, MSI1, NOTCH1, and SOX2; and absence of CD34 and CD14 expression. We conclude that adult stem cells are present in endometrial biopsies performed in a routine clinical setting, offering new large-scale approaches for future research, diagnostics, and therapies involving adult stem cells.
Subject(s)
Adult Stem Cells/cytology , Cell Separation , Endometrium/cytology , Mesenchymal Stem Cell Transplantation , Mesenchymal Stem Cells/cytology , Adult , Biopsy , Cell Differentiation/physiology , Cell Lineage/physiology , Female , Humans , Stromal Cells/cytologyABSTRACT
Androgens and insulin are endocrine key players in the pathophysiology of polycystic ovary syndrome (PCOS), a heterogenic condition of unexplained etiology and a suspected genetic background. Androgens mediate the clinical phenotype of the disease. Therefore,all criteria of the recent PCOS consensus definition are based on their biological effects. Insulin resistance, followed by compensatory hyperinsulinemia, is frequently found in patients with PCOS. Insulin resistance is correlated with a risk of metabolic complications of PCOS, and recent research has focused on possible long-term health consequences of the syndrome. Newest molecular genetic findings at the receptor level of both androgens and insulin support their pivotal role in PCOS. These results could help to better characterize the heterogenic disorder, enabling a refinement of existing individualized therapeutic strategies.
