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1.
Soc Sci Med ; 324: 115834, 2023 05.
Article in English | MEDLINE | ID: mdl-37003024

ABSTRACT

Antimicrobial resistance (AMR) continues to present a challenge to international healthcare systems and structures of public health. The focus on optimizing antibiotic prescribing in human populations has challenged healthcare systems charged with making responsible their physician-prescribers. In the United States, physicians in almost every specialty and role use antibiotics as part of their therapeutic armamentariums. In United States hospitals, most patients are administered antibiotics during their stay. Therefore, antibiotic prescribing and utilization is a commonly accepted part of medical practice. In this paper, we utilize social science work on antibiotic prescribing to examine a critical space of care in United States hospital settings. From March to August 2018, we used ethnographic methods to study hospital-based medical intensive care unit physicians at the offices and hospital floors they frequent in two urban United States teaching hospitals. We focused on eliciting the interactions and discussions surrounding antibiotic decision-making that are uniquely influenced by the context of medical intensive care units. We argue that antibiotic use in the medical intensive care units under study was shaped by urgency, hierarchy, and uncertainty representative of the medical intensive care unit's role within the larger hospital system. We conclude that by studying the culture of antibiotic prescribing in medical intensive care units, we can see more clearly both the vulnerability of the looming antimicrobial resistance crisis and by contrast the perceived insignificance of stewarding antibiotic use when considered alongside the fragility of life amidst acute medical concerns regularly experienced in the unit.


Subject(s)
Anti-Bacterial Agents , Physicians , Humans , Anti-Bacterial Agents/therapeutic use , Critical Care , Intensive Care Units , Hospitals, Teaching , Practice Patterns, Physicians' , Inappropriate Prescribing
2.
Emerg Infect Dis ; 27(8): 2127-2134, 2021 08.
Article in English | MEDLINE | ID: mdl-34287121

ABSTRACT

We performed a spatial and mixed ecologic study of community-onset Enterobacteriaceae isolates collected from a public healthcare system in Cook County, Illinois, USA. Individual-level data were collected from the electronic medical record and census tract-level data from the US Census Bureau. Associations between individual- and population-level characteristics and presence of ceftriaxone resistance were determined by logistic regression analysis. Spatial analysis confirmed nonrandom distribution of ceftriaxone resistance across census tracts, which was associated with higher percentages of Hispanic, foreign-born, and uninsured residents. Individual-level analysis showed that ceftriaxone resistance was associated with male sex, an age range of 35-85 years, race or ethnicity other than non-Hispanic Black, inpatient encounter, and percentage of foreign-born residents in the census tract of isolate provenance. Our findings suggest that the likelihood of community-onset ceftriaxone resistance in Enterobacteriaceae is influenced by geographic and population-level variables. The development of effective mitigation strategies might depend on better accounting for these factors.


Subject(s)
Ceftriaxone , Enterobacteriaceae , Adult , Aged , Aged, 80 and over , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/therapeutic use , Ceftriaxone/pharmacology , Hispanic or Latino , Humans , Illinois/epidemiology , Male , Middle Aged
3.
Infect Control Hosp Epidemiol ; 38(7): 857-859, 2017 07.
Article in English | MEDLINE | ID: mdl-28571589

ABSTRACT

Clinician education and prospective audit and feedback interventions, deployed separately and concurrently, did not reduce antimicrobial use errors or rates compared to a control group of general medicine inpatients at our public hospital. Additional research is needed to define the optimal scope and intensity of hospital antimicrobial stewardship interventions. Infect Control Hosp Epidemiol 2017;38:857-859.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Antimicrobial Stewardship/methods , Inappropriate Prescribing/statistics & numerical data , Internal Medicine/statistics & numerical data , Medical Audit , Medical Staff, Hospital/education , Adult , Aged , Decision Making, Computer-Assisted , Feedback , Female , Humans , Inappropriate Prescribing/prevention & control , Internal Medicine/education , Male , Middle Aged , Practice Guidelines as Topic
4.
Clin Microbiol Rev ; 30(1): 381-407, 2017 01.
Article in English | MEDLINE | ID: mdl-27974411

ABSTRACT

Antimicrobial stewardship is a bundle of integrated interventions employed to optimize the use of antimicrobials in health care settings. While infectious-disease-trained physicians, with clinical pharmacists, are considered the main leaders of antimicrobial stewardship programs, clinical microbiologists can play a key role in these programs. This review is intended to provide a comprehensive discussion of the different components of antimicrobial stewardship in which microbiology laboratories and clinical microbiologists can make significant contributions, including cumulative antimicrobial susceptibility reports, enhanced culture and susceptibility reports, guidance in the preanalytic phase, rapid diagnostic test availability, provider education, and alert and surveillance systems. In reviewing this material, we emphasize how the rapid, and especially the recent, evolution of clinical microbiology has reinforced the importance of clinical microbiologists' collaboration with antimicrobial stewardship programs.


Subject(s)
Anti-Infective Agents/therapeutic use , Communicable Diseases/drug therapy , Cooperative Behavior , Humans , Microbiology , Physicians , Professional Role , Program Development
6.
Clin Infect Dis ; 60(8): 1252-8, 2015 Apr 15.
Article in English | MEDLINE | ID: mdl-25595748

ABSTRACT

Antimicrobial stewardship is pivotal to improving patient outcomes, reducing adverse events, decreasing healthcare costs, and preventing further emergence of antimicrobial resistance. In an era in which antimicrobial resistance is increasing, judicious antimicrobial use is the responsibility of every healthcare provider. Antimicrobial stewardship programs (ASPs) have made headway in improving antimicrobial prescribing using such "top-down" methods as formulary restriction and prospective audit with feedback; however, engagement of prescribers has not been fully explored. Strategies that include frontline prescribers and other unit-based healthcare providers have the potential to expand stewardship, both to augment existing centralized ASPs and to provide alternative approaches to perform stewardship at healthcare facilities with limited resources. This review discusses interventions focusing on antimicrobial prescribing at the point of prescription as well as a pilot project to engage unit-based healthcare providers in antimicrobial stewardship.


Subject(s)
Anti-Infective Agents/administration & dosage , Communicable Diseases/drug therapy , Drug Prescriptions/standards , Drug Utilization/standards , Communicable Diseases/microbiology , Drug Resistance, Multiple , Humans
7.
Int J Infect Dis ; 17(8): e615-20, 2013 Aug.
Article in English | MEDLINE | ID: mdl-23474174

ABSTRACT

OBJECTIVES: Recommended doses of liposomal amphotericin B (L-AMB) range from 3 to 6 mg/kg/day, but 1mg/kg/day may be equally effective and a lower cost alternative for many indications. The objective of this analysis was to assess indications and clinical outcomes of patients who received low-dose (1mg/kg/day rounded up in 50-mg increments) and standard-dose (≥2 mg/kg/day) L-AMB. METHODS: This was a retrospective analysis of adult L-AMB recipients with suspected invasive fungal infections (IFI) at a single center from 2006 to 2011. The primary outcome was clinical response at the end of treatment. Secondary outcomes included survival and toxicity. Results were analyzed using Chi-square and descriptive statistics. RESULTS: Of 89 adult L-AMB recipients included, 36 had proven or probable IFIs. Nineteen (53%) received low doses and 17 (47%) received standard doses. Median doses were 1.5 and 3.0mg/kg/day. Cryptococcus was the most common fungal pathogen in the low-dose group (37%), and Candida spp. in the standard-dose group (47%). Forty-seven percent of subjects in both groups improved clinically. Sixty-eight percent of low-dose recipients and 76% of standard-dose recipients survived to discharge. Rates of nephrotoxicity and hypokalemia were comparable. CONCLUSIONS: Comparable rates of clinical improvement, survival to discharge, and toxicity were identified among low- and standard-dose L-AMB recipients.


Subject(s)
Amphotericin B/administration & dosage , Antifungal Agents/administration & dosage , Mycoses/drug therapy , Adult , Aged , Aged, 80 and over , Amphotericin B/adverse effects , Antifungal Agents/adverse effects , Female , Hospitalization , Humans , Liposomes , Male , Middle Aged , Mycoses/mortality , Retrospective Studies , Treatment Outcome , Young Adult
9.
Clin Infect Dis ; 53(4): 379-87, 2011 Aug.
Article in English | MEDLINE | ID: mdl-21810753

ABSTRACT

Can the use of serum procalcitonin levels safely reduce antimicrobial use in intensive care unit (ICU) patients? We performed a systematic literature review that identified 6 published randomized controlled trials comparing PCT-guided antimicrobial therapy to usual care in ICU patients, extracting data on ICU and patient characteristics, PCT guideline content, intensity of antimicrobial exposure, ICU length of stay, infection relapse, and mortality. Procalcitonin guidance was associated with significantly reduced antimicrobial exposure (effect sizes, 19.5%-38%) in all 5 studies assessing its impact on treatment duration but did not significantly impact antimicrobial exposure in the study assessing treatment initiation only. Length of ICU stay was significantly decreased in 2 studies but was unchanged in the others. Neither infection relapse nor mortality varied significantly in any of the studies. Procalcitonin guidance of antimicrobial duration appears to decrease antimicrobial use in the ICU safely and significantly and may also decrease the length of stay in the ICU.


Subject(s)
Anti-Infective Agents/administration & dosage , Bacterial Infections/blood , Calcitonin/blood , Protein Precursors/blood , Adult , Calcitonin Gene-Related Peptide , Humans , Inappropriate Prescribing , Intensive Care Units , Randomized Controlled Trials as Topic , Treatment Outcome
10.
Infect Control Hosp Epidemiol ; 32(5): 472-80, 2011 May.
Article in English | MEDLINE | ID: mdl-21515978

ABSTRACT

OBJECTIVE: To outline methods for deriving and validating intensive care unit (ICU) antimicrobial utilization (AU) measures from computerized data and to describe programming problems that emerged. DESIGN: Retrospective evaluation of computerized pharmacy and administrative data. SETTING: ICUs from 4 academic medical centers over 36 months. INTERVENTIONS: Investigators separately developed and validated programming code to report AU measures in selected ICUs. Use of antibacterial and antifungal drugs for systemic administration was categorized and expressed as antimicrobial-days (each day that each antimicrobial drug was given to each patient) and patient-days receiving antimicrobials (each day that any antimicrobial drug was given to each patient). Monthly rates were compiled and analyzed centrally, with ICU patient-days as the denominator. Results were validated against data collected from manual review of medical records. Frequent discussion among investigators aided identification and correction of programming problems. RESULTS: AU data were successfully programmed though a reiterative process of computer code revision. After identifying and resolving major programming errors, comparison of computerized patient-level data with data collected by manual review of medical records revealed discrepancies in antimicrobial-days and patient-days receiving antimicrobials that ranged from less than 1% to 17.7%. The hospital from which numerator data were derived from electronic records of medication administration had the least discrepant results. CONCLUSIONS: Computerized AU measures can be derived feasibly, but threats to validity must be sought out and corrected. The magnitude of discrepancies between computerized AU data and a gold standard based on manual review of medical records varies, with electronic records of medication administration providing maximal accuracy.


Subject(s)
Anti-Infective Agents/therapeutic use , Clinical Pharmacy Information Systems , Drug Utilization Review/methods , Intensive Care Units , Medical Records Systems, Computerized , Academic Medical Centers , Humans , Medical Records , Pharmacy Service, Hospital , Retrospective Studies , Software
11.
Am J Health Syst Pharm ; 67(8): 622-8, 2010 Apr 15.
Article in English | MEDLINE | ID: mdl-20360589

ABSTRACT

PURPOSE: The development and implementation of an extended-infusion piperacillin-tazobactam program at an urban teaching hospital are described. SUMMARY: A multidisciplinary team was formed to address the feasibility of converting from the standard 30-minute infusion to an extended infusion of piperacillin- tazobactam. Before hospitalwide implementation, feasibility studies were performed in a subset of patients to identify potential barriers to program implementation. On the day of hospitalwide conversion, the orderables for piperacillin-tazobactam were reprogrammed in the computerized prescriber-order-entry system to allow separate options for the 30-minute infusion (for pediatric patients) and the extended-infusion regimen. After selecting the orderable for the extended-infusion regimen, an electronic message appeared to remind prescribers of the rationale for this change and recommended indications for piperacillin-tazobactam. Program success was prospectively evaluated on 11 weekdays after hospitalwide conversion for all 96 adult inpatients receiving piperacillin-tazobactam. Of the 194 piperacillin-tazobactam doses observed, 90% were appropriate, with compliance increasing to 100% by the end of the observation period. There was near-complete cessation of the every-6-hour dosage interval and a marked increase in the every-8-hour and every-12-hour dosage intervals. The number of piperacillin-tazobactam doses per 1000 patient-days significantly decreased during the postimplementation period. During the postimplementation period, pharmacy expenditures related to piperacillin-tazobactam decreased by 18% and the total number of grams of piperacillin-tazobactam purchased decreased by 24%. CONCLUSION: A hospitalwide program for the administration of extended-infusion piperacillin-tazobactam was safely and successfully implemented using a multi-disciplinary approach in an urban teaching hospital.


Subject(s)
Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/economics , Critical Care , Hospitals, Teaching , Humans , Infusion Pumps , Infusions, Intravenous , Medical Errors , Patient Care Team , Penicillanic Acid/administration & dosage , Penicillanic Acid/analogs & derivatives , Penicillanic Acid/economics , Pharmacy Service, Hospital/organization & administration , Piperacillin/administration & dosage , Piperacillin/economics , Piperacillin, Tazobactam Drug Combination , Prospective Studies , Quality Assurance, Health Care
12.
Infect Control Hosp Epidemiol ; 30(2): 163-71, 2009 Feb.
Article in English | MEDLINE | ID: mdl-19090769

ABSTRACT

OBJECTIVE: To describe and measure reliability of a computer-assisted method of case vignette assembly and expert review to assess the appropriateness of antimicrobial therapy for hospitalized adults. DESIGN: Feasibility and reliability analysis of computer-assisted tool used to compare the effects of antimicrobial stewardship interventions. SETTING: Public teaching hospital. PATIENTS: Randomly selected adult antimicrobial recipients admitted to inpatient medicine services. METHODS: Clinical data abstracted from 504 paper medical records were merged with computerized laboratory and pharmacy data to assemble case vignettes that underwent expert review for appropriateness. We performed 3 validations, as follows: data for 35 vignettes abstracted independently by 2 research assistants were assessed for interrater agreement, expert review of 24 vignettes was compared with review of the corresponding paper medical records, and interrater reliability of antimicrobial appropriateness assessments by 2 experts was determined for 70 case vignettes. RESULTS: Vignette assembly and expert review each required 10-12 minutes per case. Potentially important discrepancies occurred in 0%-32% of clinical findings abstracted independently by 2 research assistants. Expert review of 24 vignettes and the corresponding full paper medical records yielded fair agreement (kappa, 0.30). The 2 experts identified inappropriate initial antimicrobial therapy in 67% and 61% of case vignettes reviewed independently; interrater agreement was improved after sequential case discussion and stringent application of appropriateness criteria (kappa, 0.72). CONCLUSIONS: Our case vignette assembly and expert review method is efficient, but improvements in both technical and human performance are needed to be able to yield valid estimates of the prevalence of inappropriate antimicrobial use. Assessments of antimicrobial appropriateness require validation.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Drug Utilization Review , Infections/drug therapy , Medical Records Systems, Computerized , Program Evaluation , Adult , Anti-Bacterial Agents/administration & dosage , Guideline Adherence , Hospitals, Public , Hospitals, Teaching , Humans , Inpatients , Practice Guidelines as Topic , Program Evaluation/standards
14.
J Clin Microbiol ; 46(4): 1553-5, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18234871

ABSTRACT

We report four adult patients who presented with septic pulmonary emboli and community-acquired methicillin-resistant Staphylococcus aureus bacteremia associated with deep tissue infections, such as pyomyositis, osteomyelitis, and prostatic abscess. The patients lacked evidence of right-sided endocarditis or thrombophlebitis. This association, previously described in children, may also be important in adults.


Subject(s)
Bacteremia/microbiology , Community-Acquired Infections/complications , Pulmonary Embolism/microbiology , Pyomyositis/complications , Sepsis/microbiology , Staphylococcal Infections/complications , Staphylococcus aureus/drug effects , Abscess/microbiology , Adult , Bacterial Toxins , Community-Acquired Infections/microbiology , Exotoxins , Humans , Leukocidins , Male , Methicillin Resistance , Middle Aged , Prostatic Diseases/microbiology , Pyomyositis/microbiology , Staphylococcal Infections/microbiology
15.
J Am Geriatr Soc ; 55(8): 1236-42, 2007 Aug.
Article in English | MEDLINE | ID: mdl-17661963

ABSTRACT

OBJECTIVES: To improve antimicrobial use in patients receiving long-term care (LTC). DESIGN: Prospective, quasi-experimental before-after assessment of the effects of physician education and guideline implementation. SETTING: Public LTC and acute care hospital. PARTICIPANTS: Twenty salaried internists who provided most of the medical care to LTC patients. INTERVENTION: National guidelines, hospital resistance data, and physician feedback were incorporated into a series of four teaching sessions presented over 18 months and into booklets detailing institutional guidelines on the optimal management of common LTC infection syndromes. MEASUREMENTS: One hundred randomly selected LTC patients treated with antimicrobials were reviewed before these interventions were implemented and 100 after, and measures of the quality of care were compared. The effect of the interventions on antimicrobial days and starts were also assessed using interrupted time series analysis. RESULTS: Charted clinical abnormalities met guideline diagnostic criteria (62% vs 38%, P=.006), and initial therapy agreed with guideline recommendations (39% vs 11%, P<.001), more often in the post- than in the preintervention cohort. Mean census-adjusted monthly LTC antimicrobial days fell 29.7%, and antimicrobial starts fell 25.9% during the intervention period; both decreases were sustained during the 2-year postintervention period. CONCLUSION: The teaching and guideline intervention improved the quality and reduced the quantity of antimicrobial use in LTC patients.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Education, Medical , Guideline Adherence , Drug Utilization/statistics & numerical data , Female , Health Facilities , Humans , Long-Term Care , Male , Middle Aged , Prospective Studies
16.
Am J Health Syst Pharm ; 63(24): 2504-8, 2006 Dec 15.
Article in English | MEDLINE | ID: mdl-17158699

ABSTRACT

PURPOSE: The perceptions of the effectiveness of antimicrobial control programs (ACPs) among infectious diseases (ID) pharmacists were studied. METHODS: A survey asking pharmacists to characterize the ACP in their hospitals and rate the program's effectiveness was distributed electronically in 1999 and by regular mail in 2000 to all 365 members of the Society of Infectious Diseases Pharmacists residing in North America. RESULTS: Of the 365 surveys distributed, 323 (88.5%) were completed, 233 of which were eligible for analysis. Most respondents (99%) indicated the use of one or more ACP components (mean +/- S.D., 4.3 +/- 1.9) in their hospitals. The ACP components used most frequently included prescriber education, review of patient medical records, formularies, prior authorization, infectious diseases consultation, and clinical practice guidelines. A similar percentage of respondents indicated that ID pharmacists and ID physicians directly participated in implementing and monitoring the effectiveness of ACPs (57% and 58%, respectively). Of the 231 respondents whose hospitals had an ACP, 73% perceived that their ACP effectively addressed antimicrobial resistance, patient outcomes, or costs, with cost reduction viewed as being accomplished more often than the improvement of patient outcomes or containment of antimicrobial resistance (62%, 35%, and 38%, respectively; p < 0.001). Many indicated uncertainty regarding the effectiveness of their ACP, with a substantial percentage of respondents believing that the level of support for these programs was inadequate. CONCLUSION: ID pharmacists in 231 North American hospitals perceived that their ACP was not sufficiently effective at improving patient outcomes, containing antimicrobial resistance, and decreasing medication costs, possibly due to inadequate institutional support for the program.


Subject(s)
Anti-Infective Agents/therapeutic use , Drug Resistance, Microbial , Infections/drug therapy , Pharmacists , Practice Guidelines as Topic , Anti-Infective Agents/economics , Attitude of Health Personnel , Cost Control , Data Collection , Drug Costs , Drug Utilization , Hospitals , Humans , Pharmacy Service, Hospital , Practice Patterns, Physicians'
17.
Med Teach ; 28(1): 77-80, 2006 Feb.
Article in English | MEDLINE | ID: mdl-16627329

ABSTRACT

Physicians in postgraduate training are expected to learn research methods but how best to achieve that curricular goal is unclear. This article describes a novel educational approach to develop research skills among infectious disease fellows. Five infectious disease fellows and two faculty members participated in a collaborative research project as a vehicle for active, problem-based learning. During the learning experience several tasks with specific learning objectives were achieved. The authors evaluated the weaknesses and strengths of the collaborative research project as an educational program. This problem-based approach for learning research methods seems more effective than traditional methods and may be applicable to a broad range of training programs.


Subject(s)
Education, Medical, Continuing/methods , Problem-Based Learning/methods , Research/education , Cohort Studies , Communicable Disease Control/methods , Communicable Disease Control/organization & administration , Communicable Disease Control/standards , Communicable Diseases , Cooperative Behavior , Education, Medical, Continuing/organization & administration , Fellowships and Scholarships , Guideline Adherence/statistics & numerical data , Illinois , Internal Medicine/organization & administration , Referral and Consultation , Research Design
19.
BMC Infect Dis ; 5: 71, 2005 Sep 15.
Article in English | MEDLINE | ID: mdl-16164757

ABSTRACT

BACKGROUND: Blood culture (BCX) use is often sub-optimal, and is a user-dependent diagnostic test. Little is known about physician training and BCX-related knowledge. We sought to assess variations in caregiver BCX-related knowledge, and their relation to medical training. METHODS: We developed and piloted a self-administered BCX-related knowledge survey instrument. Expert opinion, literature review, focus groups, and mini-pilots reduced > 100 questions in multiple formats to a final questionnaire with 15 scored content items and 4 covariate identifiers. This questionnaire was used in a cross-sectional survey of physicians, fellows, residents and medical students at a large urban public teaching hospital. The responses were stratified by years/level of training, type of specialty training, self-reported practical and theoretical BCX-related instruction. Summary scores were derived from participant responses compared to a 95% consensus opinion of infectious diseases specialists that matched an evidence based reference standard. RESULTS: There were 291 respondents (Attendings = 72, Post-Graduate Year (PGY) = 3 = 84, PGY2 = 42, PGY1 = 41, medical students = 52). Mean scores differed by training level (Attending = 85.0, PGY3 = 81.1, PGY2 = 78.4, PGY1 = 75.4, students = 67.7) [p < or = 0.001], and training type (Infectious Diseases = 96.1, Medicine = 81.7, Emergency Medicine = 79.6, Surgery = 78.5, Family Practice = 76.5, Obstetrics-Gynecology = 74.4, Pediatrics = 74.0) [p < or = 0.001]. Higher summary scores were associated with self-reported theoretical [p < or = 0.001] and practical [p = 0.001] BCX-related training. Linear regression showed level and type of training accounted for most of the score variation. CONCLUSION: Higher mean scores were associated with advancing level of training and greater subject-related training. Notably, house staff and medical students, who are most likely to order and/or obtain BCXs, lack key BCX-related knowledge. Targeted education may improve utilization of this important diagnostic tool.


Subject(s)
Blood Specimen Collection , Blood/microbiology , Clinical Competence/statistics & numerical data , Communicable Diseases/blood , Communicable Diseases/diagnosis , Data Collection , Education, Medical , Physicians , Students, Medical , Blood Specimen Collection/standards , Clinical Competence/standards , Cross-Sectional Studies , Education, Medical/standards , Humans , Medicine , Quality Control , Specialization , Surveys and Questionnaires
20.
Infect Control Hosp Epidemiol ; 26(4): 395-400, 2005 Apr.
Article in English | MEDLINE | ID: mdl-15865276

ABSTRACT

OBJECTIVE: To determine whether randomly selected intravenous (IV) antimicrobial doses dispensed from an inpatient pharmacy were administered. DESIGN: This was a prospective, cross-sectional study in which dose administration was confirmed by direct observation and by assessment of the medication administration record (MAR). A retrospective analysis of the return rate of unused IV antimicrobial doses was performed subsequently. SETTING: Medical and surgical intensive care units (ICUs) and non-ICUs of a 550-bed urban public teaching hospital. PARTICIPANTS: Hospitalized patients with an order in the pharmacy database for an IV antimicrobial during 9 non-consecutive weekdays in June 1999. RESULTS: Of 397 doses, 221 (55.7%) assessed by bedside observation and 238 (59.9%) assessed by MAR review were classified as administered; 139 doses (35.0%) were dispensed but changes in the drug order or the patient's status prevented their administration. In the subsequent assessment, of 745 IV antimicrobial doses dispensed during 24 hours, 322 (43.2%) were returned to the pharmacy unused; 423 (56.8%) of the doses-consistent with our prior observations-were presumably administered. CONCLUSIONS: Because computerized pharmacy data may overestimate actual antimicrobial consumption, such data should be validated when used in studies of hospital antimicrobial use. Dispense-return analysis offers a simple validation method.


Subject(s)
Anti-Bacterial Agents/administration & dosage , Drug Utilization Review/methods , Medical Records , Nursing Records , Pharmacy Service, Hospital/statistics & numerical data , Cross-Sectional Studies , Humans , Infusions, Intravenous , Intensive Care Units , Reproducibility of Results , Retrospective Studies
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