ABSTRACT
A case report of Gaucher's disease associated with chronic lymphocytic leukaemia is described in a patient with gout and carcinoma of the sigmoid colon. This the first reported case of Gaucher's disease associated with chronic lymphocytic leukaemia.
Subject(s)
Adenocarcinoma/complications , Colonic Neoplasms/complications , Gaucher Disease/complications , Gout/complications , Leukemia, Lymphoid/complications , Adenocarcinoma/pathology , Aged , Bone Marrow/pathology , Colonic Neoplasms/pathology , Gaucher Disease/pathology , Humans , Leukemia, Lymphoid/pathology , Liver/pathology , Lymph Nodes/pathology , MaleSubject(s)
Blood Coagulation Disorders/diagnosis , Hemorrhage/diagnosis , Blood Cell Count , Blood Coagulation , Blood Coagulation Factors/analysis , Blood Platelet Disorders/diagnosis , Blood Platelets , Diagnosis, Differential , Disseminated Intravascular Coagulation/diagnosis , Female , Hemoglobinometry , Hemophilia A/diagnosis , Hemophilia B/diagnosis , Humans , Male , Prothrombin Time , Purpura/diagnosis , Purpura, Thrombocytopenic/diagnosis , Purpura, Thrombotic Thrombocytopenic/diagnosis , Rheumatic Diseases , Telangiectasia, Hereditary Hemorrhagic/diagnosis , Thromboplastin , von Willebrand Diseases/diagnosisSubject(s)
Centrifugation, Density Gradient , Deoxyribonucleases , Gammaretrovirus/pathogenicity , Mice , Ribonucleases , Temperature , AnimalsSubject(s)
Antineoplastic Agents/adverse effects , Antineoplastic Agents/toxicity , Triethylenemelamine/adverse effects , Triethylenemelamine/toxicity , Adolescent , Adult , Aged , Animals , Blood Urea Nitrogen , Dogs , Female , Gastrointestinal Diseases/chemically induced , Haplorhini , Hematologic Diseases/chemically induced , Humans , Kidney Diseases/chemically induced , Male , Mice , Middle Aged , Nervous System Diseases/chemically induced , Rats , Uric Acid/blood , Urine/analysisABSTRACT
Brown, Eric R. (Northwestern University Medical School, Chicago, Ill.), Peter Buinauskas, and Steven O. Schwartz. Immunofluorescent antibody studies of a murine leukemia virus. J. Bacteriol. 92:978-982. 1966.-Correlation was close between in vitro complement fixation, immunodiffusion, and passive cutaneous anaphylaxis tests with the S-63 and GC murine leukemia viruses and immunofluorescence reactions with these viruses. When fluorescein-isothiocyanate-conjugated convalescent sera obtained from mice initially infected with S-63 leukemia virus were used, the reactive site was within the cytoplasm of the infected cell. By electron microscopic examination, virus particles were demonstrated in the same areas within the cells that exhibited specific fluorescence with the conjugates. Spleen and mesenteric nodes contained the most virus, whereas kidney tissues contained the least amount. Fluorescence was not observed within the nuclei of infected cells.
